Akut koroner sendromlu hastalarda hemoglobin to red cell distribution width (RDW) ratio (HRR)’nın prognozla ilişkisi

Abstract

Amaç: Son yıllarda akut koroner sendrom (AKS)’nin prognostik değerlendirmesinde hematolojik parametrelerin kullanımı yaygındır. Bu yüzden çalışmamızda, bu hastalarda hemoglobin to red cell distribution width (RDW) ratio (HRR)’nin prognozla olan ilişkisi araştırıldı. Materyal-metod: 01.09.2023- 01.04.2024 tarihleri arasında acil servise başvuran ve AKS tanısı alan hastalar retrospektif olarak değerlendirildi. HRR, hemoglobinin RDW’ye bölünmesiyle hesaplandı. Tüm hastalar HRR cut-off değerine göre yüksek ve düşük HRR’li hastalar olarak iki gruba ayrıldı. Tüm parametreler bu iki hasta grubu arasında istatistiksel olarak karşılaştırıldı. Mortalite ile ilişkili olabilecek değişkenler receiver operating characteristic (ROC) analizine tabi tutuldu. Bulgular: Yüksek HRR (>0.828) grubuna kıyasla düşük HRR (≤0.828) grubunda vazopressör, MV destek ihtiyacı ve hastane içi mortalite oranı anlamlı olarak daha yüksek tespit edildi (p<0.05 for all). ROC analizine göre, mortalite tahmini için HRR cut-off değeri 0.828 iken, sensitivite 78.8% ve spesifisite 92.5% idi (AUC: 0.885, p<0.001). Sonuç: Başvuruda ölçülen HRR, AKS’li hastalarda prognostik değeri yüksek bir belirteçtir.

Keywords

• hemoglobin/kırmızı hücre dağılım genişliği
• akut koroner sendrom
• prognoz
• mortalite

The relationship between hemoglobin to red cell distribution width (RDW) ratio (HRR) and prognosis in patients with acute coronary syndrome

Abstract

Aims: The use of hematological parameters in the prognostic assessment of acute coronary syndrome (ACS) has become common in recent years. Thus, our study aimed to evaluate the relationship between hemoglobin to red cell distribution width (RDW) ratio (HRR) and prognosis of these patients. Methods: A retrospective evaluation was conducted on patients who presented to the emergency department between 01.09.2023 and 01.04.2024 and received a diagnosis of ACS. HRR was determined by dividing the hemoglobin concentration by the red cell distribution width (RDW). The patients were categorized into two groups based on their HRR values: high HRR patients and low HRR patients, using a specified HRR cut-off value. Statistical comparisons were conducted on all parameters between the two patient groups. The variables potentially linked to mortality were analyzed using receiver operating characteristic (ROC) analysis. Results: The in-hospital mortality rate, vasopressor needs, and MV support requirements were significantly higher in the low HRR (≤0.828) group than in the high HRR (>0.828) group (p<0.05 for all). The ROC analysis revealed that the HRR cut-off value for predicting mortality was 0.828. The sensitivity was determined to be 78.8% and the specificity was 92.5% (AUC: 0.885, p<0.001). Conclusion: In patients with ACS, HRR measured at admission is a marker with a high prognostic value

Keywords

• Hemoglobin/red cell distribution width
• acute coronary syndrome
• prognosis
• mortality

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