Obez kadınlarda metaboli̇k sendrom ve metaboli̇k olarak sağlıklı obezi̇teyi̇ beli̇rlemek içi̇n yeni̇ ve geleneksel antropometri̇k endeksler

Abstract

Amaç: Geleneksel antropometrik indeksler, düşük metabolik riske sahip obez bireyleri veya metabolik olarak sağlıklı olanları ayırt etmek için yetersiz olabilir. Bu nedenle, daha yeni, yenilikçi indeksler daha iyi tanısal doğruluk sunabilir. Bu çalışmanın amacı, metabolik sendromu (MetS) tanımlamada ve Serum Ürik Asit (SUA) ve Aterojenik Plazma İndeksi (AIP) gibi metabolik risk faktörlerini değerlendirmede hem geleneksel hem de yeni antropometrik indekslerin etkinliğini değerlendirmektir. Yöntemler: Bu çalışma 292 obez kadının verilerini içeren retrospektif bir çalışmadır. Hastalar MetS varlığına ve serum ürik asit ve AIP düzeylerine göre gruplara ayrıldı. Tahmin gücü, eğri altındaki alan (AUC) karşılaştırılarak alıcı işletim karakteristik eğrileri kullanılarak tahmin edildi. Sonuçlar: Sonuçlarımız, Ağırlığa Göre Ayarlanmış Bel İndeksi (WWI) hariç tüm yeni indekslerin MetS teşhisinde potansiyel faydaya sahip olduğunu göstermiştir. Lipid Birikim Ürünü (LAP) endeksi 0,832 (%95 GA: 0,783-0,880) değeri ile MetS tanısı için en yüksek eğri altında kalan alana (AUC) sahipti. Abdominal Hacim Endeksi (AVI) ve Bel-Boy Oranı (WHtR) en yüksek duyarlılığı (%82,3) gösterirken, Bel-Trigliserit Endeksi (WTI) en yüksek özgüllüğe (%89) sahipti. Sonuçlar: Hem Visseral Adipozite İndeksi (VAI) hem de LAP indeksi %70'in üzerinde özgüllük ve duyarlılık değerlerine ulaşmıştır ve obez kadınların metabolik sendrom taramasında kullanılabilir. Buna karşılık, WWI MetS'yi tanımlamada ve SUA ile AIP gruplarını ayırt etmede istatistiksel olarak yetersiz bulunmuştur.

Keywords

• Ürik asit
• plazma aterojenik indeksi
• obezite
• metabolik sendrom

Novel and traditional anthropometric indices to identify metabolic syndrome and metabolically healthy obesity in obese women

Abstract

Aims: Traditional anthropometric indices may be inadequate for distinguishing obese individuals with low metabolic risk or those who are metabolically healthy. Therefore, newer, innovative indices may offer improved diagnostic accuracy. Current study aims to evaluate effectiveness of both traditional and novel anthropometric indices in identifying metabolic syndrome (MetS) and assessing metabolic risk factors such serum uric acid (SUA) and atherogenic index of plasma (AIP). Methods: This was a retrospective study involving data of 292 obese women. The patients were separated into groups according to presence of MetS and their SUA and AIP levels. Predictive power was estimated using receiver operating characteristic curves, by comparing the area under the curve (AUC). Results: Our results showed that all novel indices except the weight-adjusted waist index (WWI) had potential utility in diagnosing MetS. The lipid accumulation product (LAP) index had the highest AUC for MetS diagnosis, with a value of 0.832 (95% CI: 0.783–0.880). The abdominal volume index (AVI) and waist-to-height ratio (WHtR) showed the highest sensitivity (82.3%), while the waist-triglyceride index (WTI) had the highest specificity (89%). Conclusion: Notably, both the visceral adiposity index (VAI) and LAP index achieved specificity and sensitivity values exceeding 70% and can be used in MetS screening of obese women. In contrast, the WWI was found to be statistically insufficient for defining MetS and distinguishing between SUA and AIP groups.

Keywords

• Uric acid
• atherogenic index of plasma
• obesity
• metabolic syndrome

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