Ektopi̇k gebeli̇k, erken gebeli̇k kaybı ve düşük tehdi̇di̇ tanısında hemogram parametreleri̇ni̇n değerlendi̇ri̇lmesi̇

Abstract

ÖZET Amaç: Bu çalışmada, düşük tehdidi (TM), erken gebelik kaybı (EPL) ve ektopik gebelik (EP) öngörüsünde inflamatuar kan parametrelerinin önemini ve potansiyel kullanımını analiz etmek amaçlanmıştır. Materyal ve Yöntem: Ekim 2021 ve 2023 tarihleri arasında, tek bir merkezde TM, EPL ve EP tanısı konulan toplam 300 hastanın (her grup için n=100) yanı sıra ilk trimester intrauterin gebeliği olan 100 sağlıklı kadının demografik verileri ve obstetrik geçmişleri analiz edilmiştir. Bu katılımcılardan elde edilen tam kan sayımı verileri dahil edilmiştir. İstatistiksel analizlerde anlamlılık düzeyi p < 0.05 olarak belirlenmiştir. Sonuçlar: Gruplar arasında yaş, gravidite ve gebelik haftası açısından kayda değer bir farklılık olmamasına rağmen, EPL kohortu belirgin şekilde yüksek bir parite oranı sergilemiştir (p=0,003). Ayrıca, trombosit-lenfosit oranında (PLR) EPL ve TM grupları arasında (p=0,021) ve EP ve TM grupları arasında (p=0,030) kayda değer farklılıklar gözlenmiştir. Ayrıca, monosit-lenfosit oranı (MLR) ve nötrofil-lenfosit oranı (NLR) EP grubunda TM ve EPL gruplarına kıyasla daha yüksek bulunmuştur (MLR için p=0,004 ve p=0,001; NLR için her iki karşılaştırmada da p=0,000). Sonuçlar: PLR, MLR ve NLR gibi enflamatuar kan parametreleri düşük tehdidi, erken gebelik kaybı ve ektopik gebeliğin tanı ve yönetimi için önemli biyobelirteçler olarak görünmektedir. Bu bulgular PLR, MLR ve NLR'nin obstetrik uygulamaya entegre edilmesinin bu komplikasyonların erken tanı ve tedavisini kolaylaştırabileceğini düşündürmektedir.

Keywords

• Düşük tehdidi
• erken gebelik kaybı
• ektopik gebelik
• inflamasyon
• hematolojik belirteçler

Evaluation of hemogram parameters in the diagnosis of ectopic pregnancy, early pregnancy loss and threatened miscarriage

Abstract

Aims: In present study, it aimed to analyse the importance and potential use of inflammatory blood parameters in the prediction of threatened miscarriage (TM), early pregnancy loss (EPL) and ectopic pregnancy (EP). Methods: Between October 2021 and 2023, the demographic data and obstetric histories of a total of 300 patients (n=100 for each group) diagnosed with TM, EPL, and EP at a single center, as well as 100 healthy women with a first-trimester intrauterine pregnancy, were analyzed. Complete blood count data obtained from these participants included. In statistical analyses, the significance level was set at p<0.05. Results: Although there was no notable discrepancy between the groups with regard to age, gravidity, and gestational week, the EPL cohort exhibited a markedly elevated parity rate (p=0.003). Additionally, notable disparities in platelet-lymphocyte ratio (PLR) were observed between the EPL and TM groups (p=0.021) and between the EP and TM groups (p=0.030). Additionally, monocyte-lymphocyte ratio (MLR) and neutrophil-lymphocyte ratio (NLR) were found to be higher in the EP group compared to the TM and EPL groups (p=0.004 and p=0.001 for MLR; p=0.000 in both comparisons for NLR). Conclusion: Inflammatory blood parameters namely PLR, MLR, and NLR appear to be significant biomarkers for the diagnosis and management of TM, EPL, and EP. These findings suggest that integrating PLR, MLR, and NLR into obstetric practice could facilitate the early diagnosis and treatment of these complications.

Keywords

• Early pregnancy loss
• ectopic pregnancy
• hematologic markers
• inflammation
• threatened miscarriage

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