Hemodiyaliz tedavisi alan hastalarda demir sükrozun intradiyalitik kan basıncına etkisi

Abstract

Amaçlar: İntravenöz demir sükrozun vazoaktif olduğu ve hemodiyaliz hastalarında intradiyalitik kan basıncında değişikliklere yol açtığını gösteren çalışmalar vardır. İntradiyalitik hipotansiyonun vasküler tromboz, yetersiz diyaliz ve artmış mortalite ile ilişkili olduğu bildirilmiştir. İntradiyalitik hipertansiyonun ise bazı çalışmalarda artmış kardiyovasküler mortalite ve hastaneye yatış sıklığında artış ile ilişkili olduğu gösterilmiştir. Bu çalışmada, demir sükrozun hemodiyaliz hastalarında intradiyalitik kan basıncı üzerine etkisini araştırmayı amaçladık. Yöntemler: Bu çalışmada, haftada üç kez hemodiyalize giren 59 hastanın kan basınçları hemodiyaliz öncesinde ölçülerek 0. dakikada kaydedildi. Diyaliz tedavisinin ilk 30 dakikasında 100 mg/5 ml demir sükroz IV infüzyon şeklinde uygulandı ve her 30 dakikada bir kan basıncı ölçülerek kaydedildi. Aynı hastaların demir sükroz uygulanmayan bir sonraki hemodiyaliz seansında da her 30 dakikada bir kan basınçları ölçüldü. Bulgular: İki farklı hastada intradiyalitik hipotansiyon gelişti; bunlardan biri demir sükroz verilen seansta, diğeri ise demir sükroz verilmeyen seansta görüldü. İntradiyalitik hipertansiyon açısından üç farklı tanıma göre gruplar arasında anlamlı bir fark saptanmadı (p=0,134; 0,523; ve 1, sırasıyla). Sonuçlar: Demir sükroz uygulamasının ne intradiyalitik hipotansiyona ne de intradiyalitik hipertansiyona yol açmadığını bulduk.

Keywords

• İntradiyalitik hipertansiyon
• intradiyalitik hipotansiyon
• demir sükroz

Effect of iron sucrose on intradialytic blood pressure in patients receiving maintenance hemodialysis treatment

Abstract

Aims: There are studies showing that IV iron sucrose is vasoactive and causes changes in intradialytic blood pressure in hemodialysis patients. Intradialytic hypotension has been associated with vascular thrombosis, inadequate dialysis, and increased mortality. Intradialytic hypertension, has been shown in some studies to be associated with increased cardiovascular mortality and an increase in the frequency of hospitalization. In this study, we aimed to investigate the effect of iron sucrose on intradialytic blood pressure in hemodialysis patients. Methods: In this study, 59 patients undergoing hemodialysis three times a week had their blood pressure measured before hemodialysis and recorded at minute 0. 100 mg/5 ml iron sucrose was administered as an IV infusion during the first 30 minutes of dialysis treatment, and blood pressure was measured and recorded every 30 minutes. The same patient's blood pressure was measured every 30 minutes during the next hemodialysis session without iron sucrose treatment. Results: Intradialytic hypotension developed in two different patient; one patient in the session in which iron sucrose was given and one in the session in which iron sucrose was not given. There was no significant difference in intradialytic hypertension between the groups according to all three definitions of intradialytic hypertension (p=0.134; 0.523; and 1, respectively). Conclusion: We found that iron sucrose administration does not cause both intradialytic hypotension and intradialytic hypertension.

Keywords

• Iron sucrose
• intradialytic hypotension
• intradialytic hypertension

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