Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort

Mehmet Salim Demir; Gözde Ağdaş; Erdoğan Şeyran; Gürkan Güner

doi:10.47582/jompac.1850445

Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort

Abstract

Aims: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with limited survival despite multimodal treatment. This retrospective study evaluated the prognostic impact molecular markers and clinical factors on survival outcomes in a real world GBM cohort. Methods: We conducted a retrospective analysis of 60 patients diagnosed with GBM between 2020 and 2023. Clinical, radiological, surgical, and molecular data were retrospectively collected. Overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier curves, with compared with log-rank test. Multivariable Cox regression analysis was performed to identify independent prognostic factors. Results: Median OS and PFS for the entire cohort were 16.5 and 9.8 months, respectively. Molecular markers were the strongest prognostic factors: IDH-mutant and MGMT-methylated tumors showed significantly prolonged OS and PFS compared to their wild-type/unmethylated counterparts (p<.001). Surgical outcomes followed a clear gradient, with gross total resection (GTR) yielding the best survival, followed by subtotal resection (STR) and biopsy. Concurrent TMZ use was also associated with a significant improvement in OS (p<.001). Survival dynamics were further detailed using Kaplan-Meier analysis. Conclusion: This study confirms the critical prognostic role of IDH mutation and MGMT promoter methylation status in GBM, while also validating the significant survival benefit associated with maximal surgical resection and concurrent TMZ. Our real-world outcomes translate effectively into long-term survival gains, reinforcing current treatment paradigms as reliable benchmarks for clinical management.

Keywords

Ethical Statement

Ethics Approval This study was conducted in accordance with the Declaration of Helsinki and approved by the Van Training and Research Hospital (GOKAEK: 10-25, 19.12.2025 dated) local institutional ethics committee. Due to the retrospective design, informed consent was waived.

Thanks

Dear Editor-in-Chief, We would like to submit our manuscript entitled “Integrating Molecular and Clinical Determinants of Survival in a Real-World Glioblastoma Cohort” for consideration in the Journal of Medicine and Palliative Care. In this retrospective real-world study of 60 glioblastoma patients, we evaluated key molecular, clinical, and surgical factors influencing overall and progression-free survival. Our findings demonstrate that IDH mutation status, MGMT promoter methylation, and extent of resection provide clear prognostic stratification, resulting in markedly different survival trajectories among patients. Given the uniformly poor prognosis of glioblastoma, accurate survival estimation and early identification of patient subgroups are essential for appropriate treatment intensity, patient selection, and timely integration of palliative and supportive care. We believe our results offer clinically meaningful insights that may assist physicians in prognostic counseling and individualized care planning. This manuscript is original, has not been published elsewhere, and is not under consideration by another journal. All authors have approved the submission. Thank you for your consideration. Sincerely, Mehmet Salim Demir, MD Corresponding Author on behalf of all authors

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Details

Primary Language

English

Subjects

Clinical Oncology

Journal Section

Research Article

Authors

Mehmet Salim Demir ^*
0000-0002-5143-4277
Türkiye

Gözde Ağdaş
0000-0001-9771-6483
Türkiye

Erdoğan Şeyran
0000-0002-5238-0522
Türkiye

Gürkan Güner
0000-0003-2275-1158
Türkiye

Publication Date

February 20, 2026

Submission Date

December 28, 2025

Acceptance Date

January 20, 2026

Published in Issue

Year 2026 Volume: 7 Number: 1

DOI

https://doi.org/10.47582/jompac.1850445

IZ

https://izlik.org/JA48ZS42LX

Cite

RIS / Bibtex

APA

Demir, M. S., Ağdaş, G., Şeyran, E., & Güner, G. (2026). Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort. Journal of Medicine and Palliative Care, 7(1), 34-39. https://doi.org/10.47582/jompac.1850445

AMA

1.Demir MS, Ağdaş G, Şeyran E, Güner G. Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort. J Med Palliat Care / JOMPAC / jompac. 2026;7(1):34-39. doi:10.47582/jompac.1850445

Chicago

Demir, Mehmet Salim, Gözde Ağdaş, Erdoğan Şeyran, and Gürkan Güner. 2026. “Integrating Molecular and Clinical Determinants of Survival in a Real-World Glioblastoma Cohort”. Journal of Medicine and Palliative Care 7 (1): 34-39. https://doi.org/10.47582/jompac.1850445.

EndNote

Demir MS, Ağdaş G, Şeyran E, Güner G (February 1, 2026) Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort. Journal of Medicine and Palliative Care 7 1 34–39.

IEEE

[1]M. S. Demir, G. Ağdaş, E. Şeyran, and G. Güner, “Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 1, pp. 34–39, Feb. 2026, doi: 10.47582/jompac.1850445.

ISNAD

Demir, Mehmet Salim - Ağdaş, Gözde - Şeyran, Erdoğan - Güner, Gürkan. “Integrating Molecular and Clinical Determinants of Survival in a Real-World Glioblastoma Cohort”. Journal of Medicine and Palliative Care 7/1 (February 1, 2026): 34-39. https://doi.org/10.47582/jompac.1850445.

JAMA

1.Demir MS, Ağdaş G, Şeyran E, Güner G. Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort. J Med Palliat Care / JOMPAC / jompac. 2026;7:34–39.

MLA

Demir, Mehmet Salim, et al. “Integrating Molecular and Clinical Determinants of Survival in a Real-World Glioblastoma Cohort”. Journal of Medicine and Palliative Care, vol. 7, no. 1, Feb. 2026, pp. 34-39, doi:10.47582/jompac.1850445.

Vancouver

1.Mehmet Salim Demir, Gözde Ağdaş, Erdoğan Şeyran, Gürkan Güner. Integrating molecular and clinical determinants of survival in a real-world glioblastoma cohort. J Med Palliat Care / JOMPAC / jompac. 2026 Feb. 1;7(1):34-9. doi:10.47582/jompac.1850445