Laryngeal myxoma: a rare entity mimicking Reinke’s edema

Year 2026, Volume: 7 Issue: 1, 189 - 191, 20.02.2026

Ergin Bilgin , Seda Nur Saka , Şevval Günay , Aleyna Şivetoğlu

https://izlik.org/JA33SZ47TJ

Abstract

Laryngeal myxoma is a very rare benign mesenchymal tumor, which can present clinically and endoscopically simulating common glottic pathologies. We describe a case of a 56-year-old female smoker with a history of chronic hoarseness for five years. Videolaryngoscopy demonstrated bilateral vocal fold edema suggestive of Reinke’s edema. A microflap approach was utilized during suspension microlaryngoscopy, where gelatinous material was evacuated after a mucosal incision. Histological examination revealed a hypocellular tumor composed of stellate and spindle cells in a myxoid matrix. The diagnosis of laryngeal myxoma was confirmed based on Alcian blue staining and an immunohistochemical profile showing CD34 positivity and S-100 negativity. After the operation, the patient’s voice quality significantly improved, and no recurrence was observed during the 24-month follow-up period. Laryngeal myxoma should be included in the differential diagnosis of polypoid lesions that simulate Reinke’s edema. Clinical recognition is difficult, and the diagnosis is established histologically. Complete surgical excision by microlaryngoscopy is curative; however, long-term follow-up is necessary.

Keywords

Laryngeal myxoma , Reinke’s edema , microflap surgery , case report

Ethical Statement

Written consent was obtained from the patient participating in this study.

Supporting Institution

N/A

Project Number

N/A

Thanks

N/A

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