Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml)

Şeyma Özden; Arzu Karasu Çelik; Fatma Merve Tepetam; Özge Atik; Bengü Kaan

doi:10.47582/jompac.1868300

Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml)

Abstract

Aims: Marked elevation of serum total immunoglobulin E (IgE) levels (>1000 IU/ml) is most commonly associated with atopic diseases; however, its underlying etiology is highly heterogeneous. This study aimed to systematically evaluate the etiological factors associated with markedly elevated serum total IgE levels in patients attending an allergy and immunology outpatient clinic. Methods: Medical records of 1103 patients with serum total IgE levels >1000 IU/ml who presented to the allergy and immunology outpatient clinic between January 1 and September 1, 2023, were retrospectively reviewed. Patients with only a single outpatient visit and those who did not undergo adequate diagnostic evaluation to determine the cause of IgE elevation were excluded. A total of 643 patients who completed comprehensive clinical, laboratory, and diagnostic assessments were included in the final analysis. Etiological causes of IgE elevation were classified based on clinical and laboratory findings. Results: The mean age of the 643 patients was 47.55±17.00 years, and 52.9% were female. The median serum total IgE level was 1520 (1001–62,753) IU/ml. Atopic diseases were identified as the most common etiological factor (n:530, 82.4%). Other causes included infectious diseases (5.3%), inflammatory diseases (1.2%), neoplasms (0.5%), primary immunodeficiency disorders (0.2%), drug-related causes (0.2%), and other conditions (0.2%). Despite comprehensive evaluation, no underlying cause could be identified in 65 patients (10.1%), who were classified as having idiopathic total IgE elevation. Conclusion: Although markedly elevated serum total IgE levels are predominantly associated with atopic diseases, a substantial proportion of patients have alternative or unidentified etiologies. A systematic and multidisciplinary diagnostic approach is essential to accurately identify the underlying cause of IgE elevation and to guide appropriate clinical management.

Keywords

References

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Details

Primary Language

English

Subjects

Allergy, Respiratory Diseases, Chest Diseases

Journal Section

Research Article

Authors

Şeyma Özden ^*
0000-0002-6646-9894
Türkiye

Arzu Karasu Çelik This is me
0009-0008-1852-9929
Türkiye

Fatma Merve Tepetam
0000-0002-9794-5662
Türkiye

Özge Atik
0000-0003-2219-0039
Türkiye

Bengü Kaan This is me
0000-0002-5922-0847
Türkiye

Publication Date

February 20, 2026

Submission Date

January 21, 2026

Acceptance Date

February 13, 2026

Published in Issue

Year 2026 Volume: 7 Number: 1

DOI

https://doi.org/10.47582/jompac.1868300

IZ

https://izlik.org/JA53MY64JH

Cite

RIS / Bibtex

APA

Özden, Ş., Karasu Çelik, A., Tepetam, F. M., Atik, Ö., & Kaan, B. (2026). Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml). Journal of Medicine and Palliative Care, 7(1), 154-159. https://doi.org/10.47582/jompac.1868300

AMA

1.Özden Ş, Karasu Çelik A, Tepetam FM, Atik Ö, Kaan B. Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml). J Med Palliat Care / JOMPAC / jompac. 2026;7(1):154-159. doi:10.47582/jompac.1868300

Chicago

Özden, Şeyma, Arzu Karasu Çelik, Fatma Merve Tepetam, Özge Atik, and Bengü Kaan. 2026. “Beyond Atopy: Etiological Evaluation of Markedly Elevated Serum Total IgE (>1000 IU Ml)”. Journal of Medicine and Palliative Care 7 (1): 154-59. https://doi.org/10.47582/jompac.1868300.

EndNote

Özden Ş, Karasu Çelik A, Tepetam FM, Atik Ö, Kaan B (February 1, 2026) Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml). Journal of Medicine and Palliative Care 7 1 154–159.

IEEE

[1]Ş. Özden, A. Karasu Çelik, F. M. Tepetam, Ö. Atik, and B. Kaan, “Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml)”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 1, pp. 154–159, Feb. 2026, doi: 10.47582/jompac.1868300.

ISNAD

Özden, Şeyma - Karasu Çelik, Arzu - Tepetam, Fatma Merve - Atik, Özge - Kaan, Bengü. “Beyond Atopy: Etiological Evaluation of Markedly Elevated Serum Total IgE (>1000 IU Ml)”. Journal of Medicine and Palliative Care 7/1 (February 1, 2026): 154-159. https://doi.org/10.47582/jompac.1868300.

JAMA

1.Özden Ş, Karasu Çelik A, Tepetam FM, Atik Ö, Kaan B. Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml). J Med Palliat Care / JOMPAC / jompac. 2026;7:154–159.

MLA

Özden, Şeyma, et al. “Beyond Atopy: Etiological Evaluation of Markedly Elevated Serum Total IgE (>1000 IU Ml)”. Journal of Medicine and Palliative Care, vol. 7, no. 1, Feb. 2026, pp. 154-9, doi:10.47582/jompac.1868300.

Vancouver

1.Şeyma Özden, Arzu Karasu Çelik, Fatma Merve Tepetam, Özge Atik, Bengü Kaan. Beyond atopy: etiological evaluation of markedly elevated serum total IgE (>1000 IU/ml). J Med Palliat Care / JOMPAC / jompac. 2026 Feb. 1;7(1):154-9. doi:10.47582/jompac.1868300