Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience

Kübra Kurt Bilirer; Cafer Yelkenci; Selvi Aydın Şenel; Barış Boza

Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience

Abstract

Aims: To evaluate perinatal outcomes and the need for intrauterine transfusion (IUT) in pregnancies complicated by maternal Parvovirus B19 infection, and to assess the association between maternal serological patterns, fetal anemia, hydrops, and pregnancy outcomes. Methods: This retrospective study included 18 pregnancies with laboratory evidence of acute Parvovirus B19 infection among 387 screened cases between 2021 and 2025 at a tertiary referral center. Maternal infection was defined by serological and/or molecular evidence. Fetal anemia was assessed using middle cerebral artery peak systolic velocity (MCA-PSV). IUT was performed when indicated. Results: Hydrops was identified in 61.1% of cases and fetal anemia in 66.7%. IUT was performed in 55.6% of pregnancies. The overall live birth rate was 50.0%, while the live birth rate among cases undergoing IUT was 30.0%. All intrauterine fetal demises occurred in fetuses with both severe anemia and hydrops, whereas all cases without anemia or hydrops resulted in live birth. Conclusion: Fetal prognosis in Parvovirus B19 infection during pregnancy is primarily determined by the development of anemia and hydrops. Although IUT is life-saving, it does not guarantee survival in advanced cases, particularly when severe anemia and hydrops coexist.

Keywords

Supporting Institution

This research received no external funding.

Project Number

KAKEK/09.07.2025.193

Ethical Statement

This retrospective study was approved by the Ethics Committee of Başakşehir Çam and Sakura City Hospital, Istanbul, Türkiye (Approval No: KAKEK/09.07.2025.193, dated 16 July 2025). The study was conducted in accordance with the Declaration of Helsinki. Due to the retrospective design of the study, informed consent was waived by the Ethics Committee.

Thanks

The authors would like to thank the medical staff of the Perinatology Unit for their contribution to patient care.

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Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Kübra Kurt Bilirer ^*
0000-0001-8204-2375
Türkiye

Cafer Yelkenci
0009-0006-2859-5220
Türkiye

Selvi Aydın Şenel
0000-0002-8128-170X
Türkiye

Barış Boza
0000-0002-3831-3745
Türkiye

Publication Date

June 25, 2026

Submission Date

March 2, 2026

Acceptance Date

May 8, 2026

Published in Issue

Year 2026 Volume: 7 Number: 3

IZ

https://izlik.org/JA94MJ82NZ

Cite

RIS / Bibtex

APA

Kurt Bilirer, K., Yelkenci, C., Aydın Şenel, S., & Boza, B. (2026). Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience. Journal of Medicine and Palliative Care, 7(3), 475-481. https://izlik.org/JA94MJ82NZ

AMA

1.Kurt Bilirer K, Yelkenci C, Aydın Şenel S, Boza B. Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience. J Med Palliat Care / JOMPAC / jompac. 2026;7(3):475-481. https://izlik.org/JA94MJ82NZ

Chicago

Kurt Bilirer, Kübra, Cafer Yelkenci, Selvi Aydın Şenel, and Barış Boza. 2026. “Perinatal Outcomes of Maternal Parvovirus B19 Infection During Pregnancy: A Tertiary Referral Center Experience”. Journal of Medicine and Palliative Care 7 (3): 475-81. https://izlik.org/JA94MJ82NZ.

EndNote

Kurt Bilirer K, Yelkenci C, Aydın Şenel S, Boza B (June 1, 2026) Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience. Journal of Medicine and Palliative Care 7 3 475–481.

IEEE

[1]K. Kurt Bilirer, C. Yelkenci, S. Aydın Şenel, and B. Boza, “Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 3, pp. 475–481, June 2026, [Online]. Available: https://izlik.org/JA94MJ82NZ

ISNAD

Kurt Bilirer, Kübra - Yelkenci, Cafer - Aydın Şenel, Selvi - Boza, Barış. “Perinatal Outcomes of Maternal Parvovirus B19 Infection During Pregnancy: A Tertiary Referral Center Experience”. Journal of Medicine and Palliative Care 7/3 (June 1, 2026): 475-481. https://izlik.org/JA94MJ82NZ.

JAMA

1.Kurt Bilirer K, Yelkenci C, Aydın Şenel S, Boza B. Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience. J Med Palliat Care / JOMPAC / jompac. 2026;7:475–481.

MLA

Kurt Bilirer, Kübra, et al. “Perinatal Outcomes of Maternal Parvovirus B19 Infection During Pregnancy: A Tertiary Referral Center Experience”. Journal of Medicine and Palliative Care, vol. 7, no. 3, June 2026, pp. 475-81, https://izlik.org/JA94MJ82NZ.

Vancouver

1.Kübra Kurt Bilirer, Cafer Yelkenci, Selvi Aydın Şenel, Barış Boza. Perinatal outcomes of maternal Parvovirus B19 infection during pregnancy: a tertiary referral center experience. J Med Palliat Care / JOMPAC / jompac [Internet]. 2026 Jun. 1;7(3):475-81. Available from: https://izlik.org/JA94MJ82NZ