Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department

Mustafa Önder Gönen; Havva Serin Yiğit

Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department

Abstract

Aims: To evaluate the discriminative performance of the PATHOS score for in-hospital mortality risk stratification among patients admitted to a palliative care ward from the emergency department (ED). Methods: This single-center retrospective cohort study included consecutive adult patients admitted from the ED to a palliative care ward between January 2023 and January 2025. The PATHOS score (platelets, age, troponin, heart rate, oxygen saturation, systolic blood pressure) was calculated from parameters recorded at ED arrival. Patients were grouped as survivors or non-survivors. Univariate and multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were performed against in-hospital mortality, and the score's discrimination was internally validated by bootstrap resampling. Results: Of 489 patients, 118 (24.1%) died during the index admission. Non-survivors had higher mean PATHOS scores than survivors (3.31±1.03 vs. 2.01±0.85; p<0.001). The score yielded an area under the curve (AUC) of 0.824 (95% CI: 0.788-0.857); bootstrap internal validation indicated negligible optimism (optimism-corrected AUC 0.824). At the optimal cutoff of ≥3, sensitivity was 77.97%, specificity 76.82%, positive predictive value 51.69%, and negative predictive value 91.64%. In multivariable analysis, the PATHOS score (OR: 3.48, 95% CI: 2.29-5.38; p<0.001), malignancy (OR: 2.71, 95% CI: 1.98-3.72; p<0.001), and serum creatinine (OR: 1.49, 95% CI: 1.09-2.03; p=0.012) emerged as independent predictors. Conclusion: Among palliative ward admissions from the ED, the PATHOS score, computed from parameters recorded at ED arrival, showed good, internally validated discrimination for in-hospital mortality. Because the score was measured in patients already admitted to palliative care, it is best positioned as an aid to risk stratification at the point of admission rather than as an ED triage tool; external validation in independent multicenter cohorts is warranted before broader clinical adoption.

Keywords

References

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Details

Primary Language

English

Subjects

Emergency Medicine, Palliative Care

Journal Section

Research Article

Authors

Mustafa Önder Gönen ^*
0000-0002-6059-4387
Türkiye

Havva Serin Yiğit
0009-0009-1196-2057
Türkiye

Publication Date

August 15, 2026

Submission Date

April 29, 2026

Acceptance Date

July 2, 2026

Published in Issue

Year 2026 Volume: 7 Number: 4

IZ

https://izlik.org/JA97TH72SC

Cite

RIS / Bibtex

APA

Gönen, M. Ö., & Serin Yiğit, H. (2026). Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department. Journal of Medicine and Palliative Care, 7(4), 676-681. https://izlik.org/JA97TH72SC

AMA

1.Gönen MÖ, Serin Yiğit H. Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department. J Med Palliat Care / JOMPAC / jompac. 2026;7(4):676-681. https://izlik.org/JA97TH72SC

Chicago

Gönen, Mustafa Önder, and Havva Serin Yiğit. 2026. “Prediction of In-Hospital Mortality Using the PATHOS Score in Patients Admitted to the Palliative Care Ward from the Emergency Department”. Journal of Medicine and Palliative Care 7 (4): 676-81. https://izlik.org/JA97TH72SC.

EndNote

Gönen MÖ, Serin Yiğit H (August 1, 2026) Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department. Journal of Medicine and Palliative Care 7 4 676–681.

IEEE

[1]M. Ö. Gönen and H. Serin Yiğit, “Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 4, pp. 676–681, Aug. 2026, [Online]. Available: https://izlik.org/JA97TH72SC

ISNAD

Gönen, Mustafa Önder - Serin Yiğit, Havva. “Prediction of In-Hospital Mortality Using the PATHOS Score in Patients Admitted to the Palliative Care Ward from the Emergency Department”. Journal of Medicine and Palliative Care 7/4 (August 1, 2026): 676-681. https://izlik.org/JA97TH72SC.

JAMA

1.Gönen MÖ, Serin Yiğit H. Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department. J Med Palliat Care / JOMPAC / jompac. 2026;7:676–681.

MLA

Gönen, Mustafa Önder, and Havva Serin Yiğit. “Prediction of In-Hospital Mortality Using the PATHOS Score in Patients Admitted to the Palliative Care Ward from the Emergency Department”. Journal of Medicine and Palliative Care, vol. 7, no. 4, Aug. 2026, pp. 676-81, https://izlik.org/JA97TH72SC.

Vancouver

1.Mustafa Önder Gönen, Havva Serin Yiğit. Prediction of in-hospital mortality using the PATHOS Score in patients admitted to the palliative care ward from the emergency department. J Med Palliat Care / JOMPAC / jompac [Internet]. 2026 Aug. 1;7(4):676-81. Available from: https://izlik.org/JA97TH72SC