Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients

Oktay Bağdatoğlu; Pınar Ulubaşoğlu; Esra Fırat Oğuz; Mine Şebnem Karakan

Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients

Abstract

Aims: Platelet-derived growth factor-BB (PDGF-BB) is a pro-fibrotic growth factor implicated in kidney scarring and allograft injury. This study investigated whether circulating PDGF-BB levels reflect renal allograft function and intrarenal hemodynamics in kidney transplant recipients. Methods: In this single-center cross-sectional study, stable kidney transplant recipients were evaluated. Serum PDGF-BB, renal function markers (estimated glomerular filtration rate [eGFR], creatinine, urea), and Doppler ultrasonography-derived Resistive Index (RI) were measured. Because serum PDGF-BB was right-skewed, associations were assessed with Spearman rank correlation, and multivariable linear regression with log-transformed PDGF-BB identified independent predictors of eGFR. Subgroup analyses by age, donor type, hypertension, and diabetes were performed. Results: Serum PDGF-BB was inversely correlated with eGFR (Spearman ρ=−0.27, p=0.012) and positively with creatinine (ρ=+0.31, p=0.004) and urea (ρ=+0.25, p=0.022), but not with RI (ρ=+0.01, p=0.93). The inverse PDGF-BB–eGFR association was significant in younger, middle-aged, non-hypertensive, non-diabetic, and deceased-donor subgroups. PDGF-BB modestly discriminated eGFR <60 (AUC 0.674). In multivariable regression, PDGF-BB was not an independent predictor of eGFR (β=−0.19, p=0.080); hypertension was inversely associated with graft function (β=−0.27, p=0.019). Correlation on untransformed values was non-significant owing to marked right-skew. Conclusion: Higher serum PDGF-BB levels were associated with poorer renal allograft function (lower eGFR, higher creatinine and urea) but not with intrarenal RI, and PDGF-BB was not an independent predictor after adjustment for clinical factors. These findings identify PDGF-BB as a potential marker associated with lower current graft function that requires further validation rather than a stand-alone predictor, and warrant confirmation in longitudinal studies.

Keywords

Supporting Institution

None. This study received no specific grant or financial support from any funding agency in the public, commercial, or not-for-profit sectors.

Ethical Statement

This study was approved by the Clinical Research Ethics Committee of Ankara Bilkent City Hospital (Date: 19.03.2025, Decision No: TABED 2-25-1043). The study was conducted in accordance with the principles of the Declaration of Helsinki, and written informed consent was obtained from all participants.

Thanks

The authors thank the nephrology and biochemistry laboratory staff of Ankara Bilkent City Hospital for technical assistance.

References

Tang W, Zhang Y, Cui S, Yi F. The growth factors: potential biomarkers and therapeutic targets in kidney diseases. Kidney Dis. 2022;8(5):368-380. doi:10.1159/000526208
Floege J, Eitner F, Alpers CE. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol. 2008;19(1):12-23. doi:10.1681/ASN.2007050532
Jia T, Xu T, Smeets B, et al. The role of platelet-derived growth factor in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2023;34(2):241-257. doi:10.1681/ASN.2022040491
Ostendorf T, Boor P, Van Roeyen CRC, Floege J. Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis. Kidney Int Suppl. 2014;4(1):65-69. doi:10.1038/kisup.2014.12
Liu G, Changsirikulchai S, Hudkins KL, et al. Identification of platelet-derived growth factor D in human chronic allograft nephropathy. Hum Pathol. 2008;39(3):393-402. doi:10.1016/j.humpath.2007.07.008
Pozzetto U, Abeni D, Citterio F, Castagneto M, Capogrossi MC, Facchiano A. Balance of transforming growth factor-β1 and platelet-derived growth factor-BB is associated with kidney allograft rejection. Ann Clin Biochem. 2008;45(Pt 2):213-214.
Naesens M, Heylen L, Lerut E, et al. Intrarenal resistive index after renal transplantation. N Engl J Med. 2013;369(19):1797-1806. doi:10.1056/NEJMoa1301064
Stigler J, Tiefenthaler M. Value and limitations of sonography in kidney transplant recipients with special attention to the resistive index: an update. Front Nephrol. 2022;2:997839. doi:10.3389/fneph.2022.997839

Granata A, Zanoli L, Clementi S, Fatuzzo P, Di Nicolò P, Fiorini F. Resistive Intrarenal Index: myth or reality? Br J Radiol. 2014;87(1038):20140004. doi:10.1259/bjr.20140004
Tang WW, Ulich TR, Lacey DL, et al. Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol. 1996;148(4):1169-1180.
Boor P, Ostendorf T, Floege J. PDGF and the progression of renal disease. Nephrol Dial Transplant. 2014;29(suppl 1):i45-i54. doi:10.1093/ndt/gft273
Boor P, Van Roeyen CRC, Kunter U, et al. PDGF-C mediates glomerular capillary repair. Am J Pathol. 2010;177(1):58-69. doi:10.2353/ajpath.2010.091008
Abdullah FB, Sheikh AMd, Tabassum S, et al. A high-fat diet increases kidney fibrosis through regulating TGF-β and PDGF-β signaling pathways in normotensive and hypertensive rat models. Int J Mol Sci. 2025;26(16):8031. doi:10.3390/ijms26168031
Buhl EM, Djudjaj S, Klinkhammer BM, et al. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020;12(3):e11021. doi:10.15252/emmm.201911021
Akgul A, Sasak G, Basaran C, Colak T, Ozdemir FN, Haberal M. Relationship of renal Resistive Index and cardiovascular disease in renal transplant recipients. Transplant Proc. 2009;41(7):2835-2837. doi:10.1016/j.transproceed.2009.07.023
Calabia J, Torguet P, Garcia I, et al. The relationship between renal Resistive Index, arterial stiffness, and atherosclerotic burden: the link between macrocirculation and microcirculation. J Clin Hypertens (Greenwich). 2014;16(3):186-191. doi:10.1111/jch.12248
Radermacher J, Mengel M, Ellis S, et al. The renal arterial resistance index and renal allograft survival. N Engl J Med. 2003;349(2):115-124. doi:10.1056/NEJMoa022602
Schindler R, Tullius SG, Tanriver Y, et al. Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy. Kidney Int. 2003;63(6):2302-2308.
Kimura N, Kimura H, Takahashi N, et al. Renal resistive index correlates with peritubular capillary loss and arteriosclerosis in biopsy tissues from patients with chronic kidney disease. Clin Exp Nephrol. 2015;19(6): 1114-1119. doi:10.1007/s10157-015-1116-0
Yao F, Luo Y, Liu YC, et al. Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury. Inflamm Regen. 2022;42(1):44. doi:10.1186/s41232-022-00223-9

Details

Primary Language

English

Subjects

Nefroloji

Journal Section

Research Article

Authors

Oktay Bağdatoğlu ^*
0000-0002-1152-5393
Türkiye

Pınar Ulubaşoğlu
0000-0001-7008-5028
Türkiye

Esra Fırat Oğuz
0000-0002-8147-5379
Türkiye

Mine Şebnem Karakan
0000-0002-7499-1738
Türkiye

Publication Date

October 25, 2026

Submission Date

July 28, 2026

Acceptance Date

September 26, 2026

Published in Issue

Year 2026 Volume: 7 Number: 5

IZ

https://izlik.org/JA62SU78JU

Cite

RIS / Bibtex

APA

Bağdatoğlu, O., Ulubaşoğlu, P., Fırat Oğuz, E., & Karakan, M. Ş. (2026). Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients. Journal of Medicine and Palliative Care, 7(5), 1091-1097. https://izlik.org/JA62SU78JU

AMA

1.Bağdatoğlu O, Ulubaşoğlu P, Fırat Oğuz E, Karakan MŞ. Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients. J Med Palliat Care / JOMPAC / jompac. 2026;7(5):1091-1097. https://izlik.org/JA62SU78JU

Chicago

Bağdatoğlu, Oktay, Pınar Ulubaşoğlu, Esra Fırat Oğuz, and Mine Şebnem Karakan. 2026. “Serum Platelet-Derived Growth Factor-BB Levels and Renal Allograft Function in Kidney Transplant Recipients”. Journal of Medicine and Palliative Care 7 (5): 1091-97. https://izlik.org/JA62SU78JU.

EndNote

Bağdatoğlu O, Ulubaşoğlu P, Fırat Oğuz E, Karakan MŞ (October 1, 2026) Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients. Journal of Medicine and Palliative Care 7 5 1091–1097.

IEEE

[1]O. Bağdatoğlu, P. Ulubaşoğlu, E. Fırat Oğuz, and M. Ş. Karakan, “Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 5, pp. 1091–1097, Oct. 2026, [Online]. Available: https://izlik.org/JA62SU78JU

ISNAD

Bağdatoğlu, Oktay - Ulubaşoğlu, Pınar - Fırat Oğuz, Esra - Karakan, Mine Şebnem. “Serum Platelet-Derived Growth Factor-BB Levels and Renal Allograft Function in Kidney Transplant Recipients”. Journal of Medicine and Palliative Care 7/5 (October 1, 2026): 1091-1097. https://izlik.org/JA62SU78JU.

JAMA

1.Bağdatoğlu O, Ulubaşoğlu P, Fırat Oğuz E, Karakan MŞ. Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients. J Med Palliat Care / JOMPAC / jompac. 2026;7:1091–1097.

MLA

Bağdatoğlu, Oktay, et al. “Serum Platelet-Derived Growth Factor-BB Levels and Renal Allograft Function in Kidney Transplant Recipients”. Journal of Medicine and Palliative Care, vol. 7, no. 5, Oct. 2026, pp. 1091-7, https://izlik.org/JA62SU78JU.

Vancouver

1.Oktay Bağdatoğlu, Pınar Ulubaşoğlu, Esra Fırat Oğuz, Mine Şebnem Karakan. Serum platelet-derived growth factor-BB levels and renal allograft function in kidney transplant recipients. J Med Palliat Care / JOMPAC / jompac [Internet]. 2026 Oct. 1;7(5):1091-7. Available from: https://izlik.org/JA62SU78JU