The relationship between body-mass index and Helicobacter pylori infection: a case-control study

Year 2021, , 35 - 39, 05.06.2021

Suat Benek , Mehmet Zengın , Sema Zergeroğlu , Ahmet Baydar , Murat Sevmiş

https://doi.org/10.47582/jompac.873265

Abstract

Objective: Helicobacter pylori infection is one of the most common infections worldwide. There are different opinions in the literature about the relationship between H. pylori and obesity. In this study, we investigated the relationship between body-mass index (BMI) and H. pylori infection.
Material and methods: A cross-sectional study was conducted among patients who underwent endoscopic examinations at Tekirdağ University Faculty of Medicine Hospital in 2019. The prevalence of H. pylori infection was examined by biopsy. The relationship between BMI and H. pylori infection was analyzed.
Results: 51.8% of the cases in our population were positive for H. pylori infection. On histopathological examination, acute and chronic inflammation findings were higher in H. pylori-positive cases compared to H. pylori-negative cases. The prevalence of H. pylori infection was higher in patients with high BMI than those with low BMI. Statistical analysis showed a significant relationship between BMI and the prevalence of H. pylori infection (p < 0.001), and there was a positive linear correlation between these two parameters (r=0.542). When the risk factors were examined univariable, BMI was found to be a significant risk factor for H. pylori infection (p = 0.008). Multivariable analysis results revealed that BMI is an independent risk factor for H. pylori infection. (OR = 1.32 [1.09-3.46], p = 0.025).
Conclusions: Our results showed that there is a significant relationship between BMI and H. pylori infection, and high BMI is an independent risk factor for H. pylori infection.

Keywords

Body-mass index, gastritis, Helicobacter pylori, histopathological findings

Vücut-kitle indeksi ile Helicobacter pylori enfeksiyonu arasındaki ilişki: bir vaka kontrol çalışması

Abstract

Amaç: Helicobacter pilori enfeksiyonu tüm dünya genelinde oldukça yaygın olan enfeksyonlardan biridir. H. pylori ile obezite arasındaki ilişki hakkında literatürde farklı görüşler vardır. Bu çalışmada vücut-kitle indeksi (VKİ) ile H. pylori enfeksiyonu arasındaki ilişkiyi araştırdık.
Gereç ve yöntemler: 2019 yılı içerisinde Tekirdağ Üniversitesi Tıp Fakültesi Hastanesinde endoskopik muayeneleri yapılan hastalar arasında kesitsel bir çalışma yapıldı. H. pylori enfeksiyonunun prevalansı biyopsi ile incelendi. VKİ ile H. pylori enfeksiyonu arasındaki ilişki analiz edildi.
Bulgular: Popülasyonumuzdaki olguların % 51.8 'i H. pylori enfeksiyonu açısından pozitifti. Histopatolojik incelemede H. pylori-pozitif olgularda akut ve kronik inflamasyon bulguları H. pylori-negatif olgulara kıyasla daha fazla idi. VKİ’si yüksek olan hastalarda H. pylori enfeksiyonu prevalansı VKİ’si düşük olanlara göre daha fazla idi. İstatiistksel analizde VKİ ile H. pylori enfeksiyonu prevalansı arasında anlamlı bir ilişki olduğu görüldü (p < 0.001) ve bu iki parametre arasında pozitif bir doğrusal korelasyon vardı (r = 0.542). Risk faktörleri tek değişkenli olarak incelendiğinde VKİ’nin H. pylori enfeksiyonu açısından anlamlı bir risk faktörü olduğu tespit edildi (p = 0.008). Çoklu analiz sonuçları ise VKİ'nin H. pylori enfeksiyonu açısında bağımsız bir risk faktörü olduğunu ortaya koydu (OR=1.32 [1.09-3.46], p=0.025).
Sonuçlar: Bulgularımız VKİ ile H. pylori enfeksiyonu arasında anlamlı bir ilişkili olduğunu ve yüksek VKİ'nin H. pylori enfeksiyonu açısından bağımsız bir risk faktörü olduğunu gösterdi.

Keywords

Vücut-kitle indeksi, gastrit, Helicobacter pylori, hitopatolojik bulgular

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