Research Article
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Sistemik immün enflamasyon indeksleri: erken membran yırtılması ve ilişkili komplikasyonlar için yeni belirleyiciler

Year 2023, Volume: 4 Issue: 5, 516 - 523, 27.10.2023
https://doi.org/10.47582/jompac.1348845

Abstract

Amaç: Bu çalışmada, immün hücrelerden türetilen sistemik inflamasyonun yeni belirteçleri olan sistemik immün inflamasyon (SII) ve yanıt (SIRI) indeksleri ile preterm erken membran rüptürü (PPROM) ve olumsuz gebelik sonuçları arasındaki ilişkinin araştırılması amaçlandı.
Gereç ve Yöntem: Retrospektif çalışmaya 24-34. gebelik haftaları arasında PPROM ile komplike olan 75 tekil gebelik ve miadında doğum yapan 75 sağlıklı gebe (kontrol grubu) dahil edildi. Nötrofil (N), trombosit (P), lenfosit (L) ve monosit (M) sayılarına göre inflamasyon indeksleri şu şekilde hesaplandı: Nötrofil-lenfosit oranı (NLR) = N/L; trombosit-lenfosit oranı (PLR) = P/L; SII = (N×P)/L; ve SIRI = (N×M)/L.
Bulgular: Medyan NLR (4,8 vs. 3,5, p <0,001), medyan PLR (145,1 vs. 126,5, p<0,001), medyan SII (1208,6 vs. 807,4, p<0,001) ve medyan SIRI (3,1 vs. 2,0, p<0.001) PPROM grubunda kontrol grubuna göre daha yüksekti. Çoklu lojistik regresyon analizi, artan SIRI'nin (OR = 7.05, p=0.010) yanı sıra artan CRP düzeylerinin PPROM'un bağımsız belirleyicileri olduğunu gösterdi. PPROM grubunda SIRI, komplikasyon varlığında komplikasyon olmayanlara göre daha yüksekti (3,4'e karşı 2,5, p<0,001). SIRI, diğer inflamasyon indeksleriyle karşılaştırıldığında PPROM'un varlığını ve komplikasyonlarını öngörmede üstün tanısal performans gösterdi.
Sonuçlar: PPROM'lu gebelerde lökosit bazlı inflamasyon indeksleri kontrol grubuna göre daha yüksekti. SIRI'nin hem PPROM'u hem de komplikasyonları ayırt etmedeki tanısal performansı diğer lökosit bazlı inflamasyon indekslerine kıyasla daha üstündü. Bu nedenle, PPROM hastaları ayırt etmede SIRI önemli bir tarama aracı olarak hizmet edebilir.

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References

  • Committee on Practice B-O. ACOG practice bulletin no. 188: Prelabor Rupture of Membranes. Obstet Gynecol. 2018;131(1):e1-e14. doi: 10.1097/AOG.0000000000002455
  • Garg A, Jaiswal A. Evaluation and management of premature rupture of membranes: a review article. Cureus. 2023;15(3):e36615. doi: 10.7759/cureus.36615
  • Kenyon S, Boulvain M, Neilson JP. Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev. 2010(8):CD001058. doi: 10.1002/14651858.CD001058.pub2
  • Galaz J, Romero R, Slutsky R, et al. Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes. J Perinat Med. 2020;48(3):222-233. doi: 10.1515/jpm-2019-0395
  • Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015;28(12):1394-1409. doi: 10.3109/14767058.2014.958463
  • Polettini J, Silva MG, Kacerovsky M, Syed TA, Saade GR, Menon R. Screening of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) enzyme expression and activity in preterm prelabor rupture of fetal membranes. J Perinat Med. 2016;44(1):99-109. doi: 10.1515/jpm-2014-0337
  • Menon R, Behnia F, Polettini J, Richardson LS. Novel pathways of inflammation in human fetal membranes associated with preterm birth and preterm pre-labor rupture of the membranes. Semin Immunopathol. 2020;42(4):431-450. doi: 10.1007/s00281-020-00808-x
  • Musilova I, Kutova R, Pliskova L, et al. Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One. 2015;10(7):e0133929. doi: 10.1371/journal.pone.0133929
  • Rosales C. Neutrophil: a cell with many roles in inflammation or several cell types? Front Physiol. 2018;9:113. doi: 10.3389/fphys.2018.00113
  • Etyang AK, Omuse G, Mukaindo AM, Temmerman M. Maternal inflammatory markers for chorioamnionitis in preterm prelabour rupture of membranes: a systematic review and meta-analysis of diagnostic test accuracy studies. Syst Rev. 2020;9(1):141. doi: 10.1186/s13643-020-01389-4
  • Le Ray I, Mace G, Sediki M, et al. Changes in maternal blood inflammatory markers as a predictor of chorioamnionitis: a prospective multicenter study. Am J Reprod Immunol. 2015;73(1):79-90. doi: 10.1111/aji.12323
  • Back JH, Kim SY, Gu MB, et al. Proteomic analysis of plasma to identify novel biomarkers for intra-amniotic infection and/or inflammation in preterm premature rupture of membranes. Sci Rep. 2023;13(1):5658. doi: 10.1038/s41598-023-32884-y.
  • Esercan A, Demir I. Neutrophil/lymphocyte and platelet/lymphocyte ratio in preterm premature rupture of membranes. Cureus. 2023;15(5):e38664. doi: 10.7759/cureus.38664
  • Ozel A, Alici Davutoglu E, Yurtkal A, Madazli R. How do platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio change in women with preterm premature rupture of membranes, and threaten preterm labour? J Obstet Gynaecol. 2020;40(2):195-199. doi: 10.1080/01443615.2019.1621807
  • Bodaghi A, Fattahi N, Ramazani A. Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases. Heliyon. 2023;9(2):e13323. doi: 10.1016/j.heliyon.2023.e13323
  • Indrayan A, Vishwakarma G, Verma S, Sarmukaddam S, Tyagi A. Quest for biomarkers of positive health: a review. Indian J Community Med. 2023;48(3):382-389. doi: 10.4103/ijcm.ijcm_480_22
  • Gunduz O, Seven B, Ozgu-Erdinc AS, et al. Correlation of systemic inflammation biomarkers and disease severity in pregnant women with COVID-19. Rev Assoc Med Bras (1992). 2023;69(6):e20221614. doi: 10.1590/1806-9282.20221614
  • Lombardi A, Duiella S, Li Piani L, et al. Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study. Sci Rep. 2021;11(1):13350. doi: 10.1038/s41598-021-92885-7
  • Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-6222. doi: 10.1158/1078-0432.CCR-14-0442
  • Qi Q, Zhuang L, Shen Y, et al. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy. Cancer. 2016;122(14):2158-2167. doi: 10.1002/cncr.30057
  • Yun S, Yi HJ, Lee DH, Sung JH. Systemic inflammation response index and systemic immune-inflammation index for predicting the prognosis of patients with aneurysmal subarachnoid hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(8):105861. doi: 10.1016/j.jstrokecerebrovasdis.2021.105861
  • Li J, He D, Yu J, et al. Dynamic status of SII and SIRI alters the risk of cardiovascular diseases: evidence from kailuan cohort study. J Inflamm Res. 2022;15:5945-5957. doi: 10.2147/JIR.S378309
  • Krawczyk P, Sioma-Markowska U. Nutrition quality of pregnant women based on body mass index and the content of selected nutrients and energy in the daily diet. Ginekol Pol. 2021. doi: 10.5603/GP.a2021.0069
  • Committee on Practice B-O. ACOG Practice Bulletin No. 199: Use of prophylactic antibiotics in labor and delivery. Obstet Gynecol. 2018;132(3):e103-e119. doi: 10.1097/AOG.0000000000002833
  • Quinn JA, Munoz FM, Gonik B, et al. Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data. Vaccine. 2016;34(49):6047-6056. doi: 10.1016/j.vaccine.2016.03.045
  • Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126(5):1763-1768. doi: 10.1213/ANE.0000000000002864
  • DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837-845.
  • Areia AL, Moura P, Mota-Pinto A, CRD PNm. The role of innate immunity in spontaneous preterm labor: A systematic review. J Reprod Immunol. 2019;136:102616. doi: 10.1016/j.jri.2019.102616
  • Menon R, Fortunato SJ. Infection and the role of inflammation in preterm premature rupture of the membranes. Best Pract Res Clin Obstet Gynaecol. 2007;21(3):467-478. doi: 10.1016/j.bpobgyn.2007.01.008
  • Vadillo-Ortega F, Estrada-Gutierrez G. Role of matrix metalloproteinases in preterm labour. BJOG. 2005;112 Suppl 1:19-22. doi: 10.1111/j.1471-0528.2005.00579.x
  • Bouvier D, Forest JC, Blanchon L, et al. Risk factors and outcomes of preterm premature rupture of membranes in a cohort of 6968 pregnant women prospectively recruited. J Clin Med. 2019;8(11):1987. doi: 10.3390/jcm8111987
  • Jena BH, Biks GA, Gete YK, Gelaye KA. Incidence of preterm premature rupture of membranes and its association with inter-pregnancy interval: a prospective cohort study. Sci Rep. 2022;12(1):5714. doi: 10.1038/s41598-022-09743-3
  • Musilova I, Pliskova L, Gerychova R, et al. Maternal white blood cell count cannot identify the presence of microbial invasion of the amniotic cavity or intra-amniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One. 2017;12(12):e0189394. doi: 10.1371/journal.pone.0189394
  • Yoon BH, Jun JK, Park KH, Syn HC, Gomez R, Romero R. Serum C-reactive protein, white blood cell count, and amniotic fluid white blood cell count in women with preterm premature rupture of membranes. Obstet Gynecol. 1996;88(6):1034-1040. doi: 10.1016/s0029-7844(96)00339-0
  • Eriç Horasanlı J, Alp EC, Bülbül R. Evaluation of complete blood cell count parameters in the diagnosis of threatened preterm labor and premature rupture of membranes. Dubai Med J. 2022;5(3):157-162.
  • Koseoglu SB, Guzel AI, Deveer R, et al. Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes. Ginekol Pol. 2014;85(7):516-520. doi: 10.17772/gp/1763
  • Ekin A, Gezer C, Kulhan G, Avci ME, Taner CE. Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes? J Obstet Gynaecol Res. 2015;41(1):23-28. doi: 10.1111/jog.12484
  • Uckan K, Baskiran Y, Celegen I. Association of subclinical markers of inflammation with preterm premature rupture of membranes and adverse neonatal results: a case control study. Arch Gynecol Obstet. 2022;306(6):2063-2068. doi: 10.1007/s00404-022-06756-1
  • Toprak E, Bozkurt M, Dincgez Cakmak B, et al. Platelet-to-lymphocyte ratio: A new inflammatory marker for the diagnosis of preterm premature rupture of membranes. J Turk Ger Gynecol Assoc. 2017;18(3):122-126. doi: 10.4274/jtgga.2017.0028
  • Sharami SH, Biazar G, Farzi F, et al. The association between platelets/lymphocyte ratio and premature rupture of membranes. Int J Women’s Health Reprod Sci. 2021;9(1):80-83.
  • Badimon L, Pena E, Arderiu G, et al. C-reactive protein in atherothrombosis and angiogenesis. Front Immunol. 2018;9:430. doi: 10.3389/fimmu.2018.00430
  • Su Y, Gao J, Kaur P, Wang Z. Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases. Pharmaceutics. 2020;12(12):1222. doi: 10.3390/pharmaceutics12121222
  • Dundar B, Dincgez Cakmak B, Ozgen G, Tasgoz FN, Guclu T, Ocakoglu G. Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes. J Obstet Gynaecol Res. 2018;44(1):67-73. doi: 10.1111/jog.13484
  • Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol. 2003;101(1):178-193. doi: 10.1016/s0029-7844(02)02366-9
  • Xie A, Zhang W, Chen M, et al. Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis. Med Sci Monit. 2015;21:390-395. doi: 10.12659/MSM.891203
  • Tanacan A, Uyanik E, Unal C, Beksac MS. A cut-off value for systemic immune-inflammation index in the prediction of adverse neonatal outcomes in preterm premature rupture of the membranes. J Obstet Gynaecol Res. 2020;46(8):1333-1341. doi: 10.1111/jog.14320

Systemic immune inflammation indices: novel predictors for preterm premature rupture of membranes and associated complications

Year 2023, Volume: 4 Issue: 5, 516 - 523, 27.10.2023
https://doi.org/10.47582/jompac.1348845

Abstract

Aim: This study aimed to investigate the relationship between systemic immune inflammation (SII) and response indices (SIRI), which are new markers of systemic inflammation derived from immune cells, and preterm premature rupture of membranes (PPROM), as well as adverse pregnancy outcomes.
Materials and Methods: The retrospective study included 75 singleton pregnancies complicated with PPROM between 24 and 34 gestational weeks and 75 healthy pregnant women who delivered at term (control group). Inflammation indices were calculated based on neutrophil (N), platelet (P), lymphocyte (L), and monocyte (M) counts as follows: The neutrophil-to-lymphocyte ratio (NLR) = N/L; the platelet-to-lymphocyte ratio (PLR) = P/L; SII = (N×P)/L; and SIRI = (N×M)/L.
Results: The median NLR (4.8 vs. 3.5, p <0.001), median PLR (145.1 vs. 126.5, p<0.001), median SII (1208.6 vs. 807.4, p<0.001), and median SIRI (3.1 vs. 2.0, p<0.001) were higher in the PPROM group than the control group. Multiple logistic regression analysis showed that increased SIRI (OR = 7.05, p=0.010), as well as increased CRP levels were determined as independent predictors of PPROM. In PPROM group, SIRI was higher in the presence with complications compared to without complications (3.4 vs. 2.5, p<0.001). The SIRI showed superior diagnostic performance in predicting the presence and complications of PPROM compared to other inflammation indices.
Conclusions: PPROM had higher leukocyte-based inflammation indices than the control group. Due to superior diagnostic performance of SIRI in distinguishing both PPROM and complications compared to other leukocyte-based inflammation indices, it may serve as a significant screening tool in PPROM.

References

  • Committee on Practice B-O. ACOG practice bulletin no. 188: Prelabor Rupture of Membranes. Obstet Gynecol. 2018;131(1):e1-e14. doi: 10.1097/AOG.0000000000002455
  • Garg A, Jaiswal A. Evaluation and management of premature rupture of membranes: a review article. Cureus. 2023;15(3):e36615. doi: 10.7759/cureus.36615
  • Kenyon S, Boulvain M, Neilson JP. Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev. 2010(8):CD001058. doi: 10.1002/14651858.CD001058.pub2
  • Galaz J, Romero R, Slutsky R, et al. Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes. J Perinat Med. 2020;48(3):222-233. doi: 10.1515/jpm-2019-0395
  • Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015;28(12):1394-1409. doi: 10.3109/14767058.2014.958463
  • Polettini J, Silva MG, Kacerovsky M, Syed TA, Saade GR, Menon R. Screening of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) enzyme expression and activity in preterm prelabor rupture of fetal membranes. J Perinat Med. 2016;44(1):99-109. doi: 10.1515/jpm-2014-0337
  • Menon R, Behnia F, Polettini J, Richardson LS. Novel pathways of inflammation in human fetal membranes associated with preterm birth and preterm pre-labor rupture of the membranes. Semin Immunopathol. 2020;42(4):431-450. doi: 10.1007/s00281-020-00808-x
  • Musilova I, Kutova R, Pliskova L, et al. Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One. 2015;10(7):e0133929. doi: 10.1371/journal.pone.0133929
  • Rosales C. Neutrophil: a cell with many roles in inflammation or several cell types? Front Physiol. 2018;9:113. doi: 10.3389/fphys.2018.00113
  • Etyang AK, Omuse G, Mukaindo AM, Temmerman M. Maternal inflammatory markers for chorioamnionitis in preterm prelabour rupture of membranes: a systematic review and meta-analysis of diagnostic test accuracy studies. Syst Rev. 2020;9(1):141. doi: 10.1186/s13643-020-01389-4
  • Le Ray I, Mace G, Sediki M, et al. Changes in maternal blood inflammatory markers as a predictor of chorioamnionitis: a prospective multicenter study. Am J Reprod Immunol. 2015;73(1):79-90. doi: 10.1111/aji.12323
  • Back JH, Kim SY, Gu MB, et al. Proteomic analysis of plasma to identify novel biomarkers for intra-amniotic infection and/or inflammation in preterm premature rupture of membranes. Sci Rep. 2023;13(1):5658. doi: 10.1038/s41598-023-32884-y.
  • Esercan A, Demir I. Neutrophil/lymphocyte and platelet/lymphocyte ratio in preterm premature rupture of membranes. Cureus. 2023;15(5):e38664. doi: 10.7759/cureus.38664
  • Ozel A, Alici Davutoglu E, Yurtkal A, Madazli R. How do platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio change in women with preterm premature rupture of membranes, and threaten preterm labour? J Obstet Gynaecol. 2020;40(2):195-199. doi: 10.1080/01443615.2019.1621807
  • Bodaghi A, Fattahi N, Ramazani A. Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases. Heliyon. 2023;9(2):e13323. doi: 10.1016/j.heliyon.2023.e13323
  • Indrayan A, Vishwakarma G, Verma S, Sarmukaddam S, Tyagi A. Quest for biomarkers of positive health: a review. Indian J Community Med. 2023;48(3):382-389. doi: 10.4103/ijcm.ijcm_480_22
  • Gunduz O, Seven B, Ozgu-Erdinc AS, et al. Correlation of systemic inflammation biomarkers and disease severity in pregnant women with COVID-19. Rev Assoc Med Bras (1992). 2023;69(6):e20221614. doi: 10.1590/1806-9282.20221614
  • Lombardi A, Duiella S, Li Piani L, et al. Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study. Sci Rep. 2021;11(1):13350. doi: 10.1038/s41598-021-92885-7
  • Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-6222. doi: 10.1158/1078-0432.CCR-14-0442
  • Qi Q, Zhuang L, Shen Y, et al. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy. Cancer. 2016;122(14):2158-2167. doi: 10.1002/cncr.30057
  • Yun S, Yi HJ, Lee DH, Sung JH. Systemic inflammation response index and systemic immune-inflammation index for predicting the prognosis of patients with aneurysmal subarachnoid hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(8):105861. doi: 10.1016/j.jstrokecerebrovasdis.2021.105861
  • Li J, He D, Yu J, et al. Dynamic status of SII and SIRI alters the risk of cardiovascular diseases: evidence from kailuan cohort study. J Inflamm Res. 2022;15:5945-5957. doi: 10.2147/JIR.S378309
  • Krawczyk P, Sioma-Markowska U. Nutrition quality of pregnant women based on body mass index and the content of selected nutrients and energy in the daily diet. Ginekol Pol. 2021. doi: 10.5603/GP.a2021.0069
  • Committee on Practice B-O. ACOG Practice Bulletin No. 199: Use of prophylactic antibiotics in labor and delivery. Obstet Gynecol. 2018;132(3):e103-e119. doi: 10.1097/AOG.0000000000002833
  • Quinn JA, Munoz FM, Gonik B, et al. Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data. Vaccine. 2016;34(49):6047-6056. doi: 10.1016/j.vaccine.2016.03.045
  • Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126(5):1763-1768. doi: 10.1213/ANE.0000000000002864
  • DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837-845.
  • Areia AL, Moura P, Mota-Pinto A, CRD PNm. The role of innate immunity in spontaneous preterm labor: A systematic review. J Reprod Immunol. 2019;136:102616. doi: 10.1016/j.jri.2019.102616
  • Menon R, Fortunato SJ. Infection and the role of inflammation in preterm premature rupture of the membranes. Best Pract Res Clin Obstet Gynaecol. 2007;21(3):467-478. doi: 10.1016/j.bpobgyn.2007.01.008
  • Vadillo-Ortega F, Estrada-Gutierrez G. Role of matrix metalloproteinases in preterm labour. BJOG. 2005;112 Suppl 1:19-22. doi: 10.1111/j.1471-0528.2005.00579.x
  • Bouvier D, Forest JC, Blanchon L, et al. Risk factors and outcomes of preterm premature rupture of membranes in a cohort of 6968 pregnant women prospectively recruited. J Clin Med. 2019;8(11):1987. doi: 10.3390/jcm8111987
  • Jena BH, Biks GA, Gete YK, Gelaye KA. Incidence of preterm premature rupture of membranes and its association with inter-pregnancy interval: a prospective cohort study. Sci Rep. 2022;12(1):5714. doi: 10.1038/s41598-022-09743-3
  • Musilova I, Pliskova L, Gerychova R, et al. Maternal white blood cell count cannot identify the presence of microbial invasion of the amniotic cavity or intra-amniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One. 2017;12(12):e0189394. doi: 10.1371/journal.pone.0189394
  • Yoon BH, Jun JK, Park KH, Syn HC, Gomez R, Romero R. Serum C-reactive protein, white blood cell count, and amniotic fluid white blood cell count in women with preterm premature rupture of membranes. Obstet Gynecol. 1996;88(6):1034-1040. doi: 10.1016/s0029-7844(96)00339-0
  • Eriç Horasanlı J, Alp EC, Bülbül R. Evaluation of complete blood cell count parameters in the diagnosis of threatened preterm labor and premature rupture of membranes. Dubai Med J. 2022;5(3):157-162.
  • Koseoglu SB, Guzel AI, Deveer R, et al. Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes. Ginekol Pol. 2014;85(7):516-520. doi: 10.17772/gp/1763
  • Ekin A, Gezer C, Kulhan G, Avci ME, Taner CE. Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes? J Obstet Gynaecol Res. 2015;41(1):23-28. doi: 10.1111/jog.12484
  • Uckan K, Baskiran Y, Celegen I. Association of subclinical markers of inflammation with preterm premature rupture of membranes and adverse neonatal results: a case control study. Arch Gynecol Obstet. 2022;306(6):2063-2068. doi: 10.1007/s00404-022-06756-1
  • Toprak E, Bozkurt M, Dincgez Cakmak B, et al. Platelet-to-lymphocyte ratio: A new inflammatory marker for the diagnosis of preterm premature rupture of membranes. J Turk Ger Gynecol Assoc. 2017;18(3):122-126. doi: 10.4274/jtgga.2017.0028
  • Sharami SH, Biazar G, Farzi F, et al. The association between platelets/lymphocyte ratio and premature rupture of membranes. Int J Women’s Health Reprod Sci. 2021;9(1):80-83.
  • Badimon L, Pena E, Arderiu G, et al. C-reactive protein in atherothrombosis and angiogenesis. Front Immunol. 2018;9:430. doi: 10.3389/fimmu.2018.00430
  • Su Y, Gao J, Kaur P, Wang Z. Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases. Pharmaceutics. 2020;12(12):1222. doi: 10.3390/pharmaceutics12121222
  • Dundar B, Dincgez Cakmak B, Ozgen G, Tasgoz FN, Guclu T, Ocakoglu G. Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes. J Obstet Gynaecol Res. 2018;44(1):67-73. doi: 10.1111/jog.13484
  • Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol. 2003;101(1):178-193. doi: 10.1016/s0029-7844(02)02366-9
  • Xie A, Zhang W, Chen M, et al. Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis. Med Sci Monit. 2015;21:390-395. doi: 10.12659/MSM.891203
  • Tanacan A, Uyanik E, Unal C, Beksac MS. A cut-off value for systemic immune-inflammation index in the prediction of adverse neonatal outcomes in preterm premature rupture of the membranes. J Obstet Gynaecol Res. 2020;46(8):1333-1341. doi: 10.1111/jog.14320

Details

Primary Language English
Subjects Infant and Child Health, Pediatric Intensive Care , Neonatology
Journal Section Research Articles [en] Araştırma Makaleleri [tr]
Authors

Gökçe Naz KÜÇÜKBAŞ 0000-0002-2755-3700

Arzu YAVUZ

Early Pub Date October 26, 2023
Publication Date October 27, 2023
Published in Issue Year 2023 Volume: 4 Issue: 5

Cite

AMA KÜÇÜKBAŞ GN, YAVUZ A. Systemic immune inflammation indices: novel predictors for preterm premature rupture of membranes and associated complications. J Med Palliat Care / JOMPAC / jompac. October 2023;4(5):516-523. doi:10.47582/jompac.1348845

TR DİZİN ULAKBİM and International Indexes (1d)

Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]



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Our journal is in TR-Dizin, DRJI (Directory of Research Journals Indexing, General Impact Factor, Google Scholar, Researchgate, CrossRef (DOI), ROAD, ASOS Index, Turk Medline Index, Eurasian Scientific Journal Index (ESJI), and Turkiye Citation Index.

EBSCO, DOAJ, OAJI and ProQuest Index are in process of evaluation. 

Journal articles are evaluated as "Double-Blind Peer Review"