Predictive value of platelet/albumin ratio in coronary slow-flow patients

Year 2024, Volume: 5 Issue: 6, 304 - 308, 23.12.2024

Yunus Emre Yavuz , Sefa Tatar , Muzaffer Aslan

Abstract

Aims:The pathophysiology of coronary slow flow is not yet fully understood, and it is thought to be related to multiple mechanisms such as endothelial dysfunction, microvascular disorder, and atherosclerosis. In this study, we aimed to investigate the predictive value of platelet/albumin ratio (PAR) in coronary slow flow patients (CSF). In addition, we compared it with other current parameters containing albumin.
Methods: The study was designed retrospectively. The study population included a review of the medical records of 260 people who underwent coronary angiography from 2020 to 2023. The study groups consisted of 108 patients with coronary slow flow and 101 patients with normal coronary arteries who met the inclusion criteria. Various parameters such as demographic data, Platelet/Albumin Ratio and prognostic nutritional index were compared between these two groups. ROC analysis was performed on these parameters.
Results: There was no significant difference between the coronary slow flow and control groups in terms of basic demographic characteristics such as age, gender and smoking, but BMI (p<0.001), LDL (p:0.026) and total cholesterol (p:0.041) ratios were higher in the coronary slow flow group. PAR showed a significant difference between the coronary slow flow group and the control group (p:0.022). Prognostic nutritional index was not significant (p:0.142). ROC curve analysis for the PAR showed a moderate discriminatory ability with an area under the curve (ROC) of 0.592 (95% CI: 0.517-0.667). Conversely, the prognostic nutritional index exhibited limited diagnostic performance with an AUC of 0.441 (95% CI: 0.365-0.522).
Conclusion: These findings suggest that easily measurable PAR may be a valuable biomarker in assessing coronary slow flow, especially in resource-limited settings. Not only does PAR demonstrate a discriminatory ability, but it also outperforms other traditional biomarkers like the prognostic nutritional index (PNI) in this specific patient population.

Keywords

Coronary angiography, blood platelets, albumin, coronary slow flow

Ethical Statement

Ethics Committee Approval: The study received ethical approval from the research committee of Siirt Training and Research Hospital on December 14, 2023, with reference number 94582.

Koroner Yavaş Akım Hastalarında Trombosit/Albümin Oranının Prediktif Değeri

Abstract

Amaç
Koroner yavaş akımın patofizyolojisi henüz tam olarak anlaşılamamıştır ve endotel disfonksiyonu, mikrovasküler bozukluk ve ateroskleroz gibi birçok mekanizma ile ilişkili olduğu düşünülmektedir. Bu çalışmada koroner yavaş akım hastalarında Trombosit/Albümin Oranının prediktif değerini araştırmayı amaçladık. Ek olarak, albümin içeren diğer güncel parametrelerle karşılaştırdık.

Yöntemler
Çalışma retrospektif olarak tasarlandı. Çalışma popülasyonu 2020'den 2023'e kadar koroner anjiyografi yapılan 260 kişinin tıbbi kayıtlarının gözden geçirilmesini içeriyordu. Çalışma grupları, çalışmaya dahil edilme kriterlerine uyan 108 koroner yavaş akım hastası ve koroner arterleri normal olan 101 hastadan oluşuyordu. Bu iki grup arasında demografik veriler, Trombosit/Albümin Oranının ve prognostik beslenme indeksi gibi çeşitli parametreler karşılaştırıldı. Bu parametreler üzerinde ROC analizi yapıldı.

Bulgular
Koroner yavaş akım ve kontrol gruplarının temel özellikleri arasında; yaş, cinsiyet ve sigara kullanımı gibi temel demografik özellikler açısından anlamlı bir fark yoktu, ancak koroner yavaş akım grubunda BMİ (p<0,001), LDL (p:0,026) ve total kolesterol (p:0,041) oranları daha yüksekti. Trombosit/Albümin Oranı, koroner yavaş akım grubu ile kontrol grubu arasında anlamlı bir fark gösterdi (p:0.022). Prognostik beslenme indeksi anlamlı değildi (p:0.142). Trombosit/Albümin Oranı için ROC eğrisi analizi, 0.592 (%95 CI: 0.517-0.667) eğrinin altındaki bir alanla (ROC) orta derecede ayırt edici bir yetenek gösterdi. Tersine, prognostik beslenme indeksi 0.441 AUC ile sınırlı tanısal performans sergiledi (% 95 CI: 0.365-0.522).

Sonuç
Bu bulgular, kolayca ölçülebilir Trombosit/Albümin oranının, özellikle kaynak sınırlı ortamlarda, koroner yavaş akışın değerlendirilmesinde değerli bir biyobelirteç olabileceğini düşündürmektedir. Trombosit/Albümin oranının sadece ayırt edici bir yetenek göstermekle kalmaz, aynı zamanda bu spesifik hasta popülasyonunda prognostik beslenme indeksi gibi diğer geleneksel biyobelirteçlerden daha iyi performans gösterir.

Keywords

Koroner anjiyografi, trombosit, albümin, koroner yavaş akım

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