İnflamatuar bir belirteç olarak monosit-HDL oranı: kan basıncı modellerini yansıtır mı ?

Year 2025, Volume: 6 Issue: 4, 323 - 327, 31.08.2025

Ramazan Astan , Ramazan Dayanan

https://doi.org/10.47582/jompac.1718764

Abstract

ÖZ
Arka plan: Monosit-yüksek yoğunluklu lipoprotein kolesterol oranı (MHO), kardiyovasküler riskle ilişkili yeni bir inflamatuar belirteç olarak ortaya çıkmıştır. Hem hipertansiyon hemde non-dipper paternin kardiyovasküler morbidite ve mortalite artışına katkıda bulunduğu bilinmektedir. Ancak, MHO ile sirkadiyen kan basıncı değişimleri arasındaki potansiyel ilişki hala belirsizliğini korumaktadır.
Amaç: Hipertsnsiyonu olan ve olmayan bireylerde 24 saatlik ayaktan kan basıncı ölçümü (AKBÖ) ile değerlendirilen dipper paterni ile MHO arasındaki ilişkiyi araştırmak.
Yöntemler: Çalışmaya AKBÖ uygulanan toplam 160 yetişkin (ortalama yaş 52,7 ± 12.1 yıl; %41.9 erkek) dahil edildi. Katlımcılar hipertansif durumları ve dipper paternlerine göre dört alt gruba ayrıldı;normotansif dipper,normotansif non-dipper,hipertansif dipper,hipertansif dipper olmayan. MHO değerleri bu gruplar arasında karşılaştırıldı. MHO’nın normal olmayan dağılımı nedeniyle, istatistiksel analizler parametrik olmayan yöntemler kullanılarak gerçekleştirildi.
Bulgular: Hipertansif ve normotansif katılımcılar (p:0.319) veya dört alt grup (p:0.436) arasında MHO’da istatistiksel olarak anlamlı bir fark izlenmedi. Benzer şekilde, tüm katılımcılar arasında MHO ile dipper paterni arasında anlamlı bir ilişki yoktu (p:0,714).
Sonuç: MHO’nın hipertansif durum veya sirkadiyen kan basıncı varyasyon paternleriyle ilişkili görünmemektedir. MHO’nın kan basıncı fizyolojisindeki potansiyel rolünü açılığa kavuşturmak için daha büyük kohortlar ve uzunlamasına tasarımlarla daha fazla çalışmaya ihtiyaç vardır.

Keywords

Monosit-HDL oanı , Ambulatuar Kan Basıncı , Hipertansiyon , Dipper , Dipper Olmayan

Monocyte-to-HDL ratio as an inflammatory marker: does it reflect blood pressure patterns?

Abstract

Aims: The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as a novel inflammatory marker associated with cardiovascular risk. Both hypertension (HT) and non-dipping blood pressure patterns are known to contribute to increased cardiovascular morbidity and mortality. However, the potential association between MHR and circadian blood pressure variations remains unclear. To investigate the relationship between MHR and dipper pattern status, as assessed by 24 hour ambulatory blood pressure monitoring (ABPM), in individuals with and without HT.
Methods: A total of 160 adults (mean age 52.7±12.1 years; 41.9% male) who underwent ABPM were included in the study. Participants were divided into four subgroups based on their hypertensive status and dipping pattern: normotensive dipper, normotensive non-dipper, hypertensive dipper, and hypertensive non-dipper. MHR values were compared among these groups. Due to the non-normal distribution of MHR, statistical analyses were performed using non-parametric methods.
Results: No statistically significant difference in MHR was observed between hypertensive and normotensive participants (p=0.319) or among the four subgroups (p=0.436). Similarly, there was no significant association between MHR and the dipper pattern across all participants (p=0.714).
Conclusion: MHR does not appear to be associated with hypertensive status or circadian blood pressure variation patterns. Further studies with larger cohorts and longitudinal designs are needed to clarify the potential role of MHR in blood pressure physiology.

Keywords

Monocyte to HDL cholesterol ratio , ambulatory blood pressure monitoring , hypertension , dipper pattern , non dipper pattern

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