Research Article
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Comparison of pulsed radiofrequency and steroid injection in the treatment of carpal tunnel syndrome guided by USG imaging

Year 2025, Volume: 6 Issue: 4, 388 - 395, 31.08.2025
https://doi.org/10.47582/jompac.1747756

Abstract

Aims: The research evaluated the effectiveness between ultrasonography-guided pulsed radiofrequency treatment and steroid injection therapy for carpal tunnel syndrome.
Methods: The research included 60 patients who received carpal tunnel syndrome diagnoses. The patients received their treatment based on two distinct approaches which formed separate groups: 30 patients who underwent ultrasonography-guided injection of 40 mg methylprednisolone acetate and 30 patients who underwent ultrasonography-guided application of pulsed radiofrequency targeting the median nerve at 42°C for 120 seconds. Visual Analog Scale (VAS) score, Boston Carpal Tunnel Scale and physical examination findings were evaluated before treatment, at 1, 3 and 6 months. All patients underwent EMG before the procedure and at 6 months.
Results: At baseline, no significant variations were observed across groups regarding demographic characteristics as well as clinical parameters. At the third month, the VAS score decreased to 2.9±1.5 in the RF group while it was still 3.8±2.1 in the steroid group (p=0.048). Functional scores of the Boston scale were 1.6±0.7 in the pulsed radiofrequency group and 2.0±0.8 in the steroid group (p=0.037). In the electrophysiologic evaluation at the sixth month, motor distal latency was 3.9±0.7 ms in the RF group versus 4.3±0.8 ms in the steroid group (p=0.041). The rate of more than 50% improvement in VAS score was 80% in the RF group compared to 60% in the steroid group.
Conclusion: Pulsed radiofrequency therapy delivers superior long-term results than steroid injection does. As a minimally invasive method, it should be evaluated before surgery.

Ethical Statement

This study was approved by the Adana Şehir Training and Research Hospital Scientific Ethics Board with approval dated 08.05.2025 with reference number 516.

Thanks

We thank Prof. Dr. Yurdal Gezercan for his contributions.

References

  • Osiak K, Elnazir P, Walocha JA, Pasternak A. Carpal tunnel syndrome: state-of-the-art review. Folia Morphol (Warsz). 2022;81(4):851-862. doi: 10.5603/FM.a2021.0121
  • Wietemborek PT, Kacprzak-Czapiewska K, Bartoszuk A, Kułakowski A. Carpal tunnel syndrome conservative treatment: a literature review. Adv Psychiatry Neurol. 2022;31(4):85-94. doi:10.5114/apn.2022.116889
  • Hernández-Secorún M, Montaña-Cortés R, Hidalgo-García C, et al. Effectiveness of conservative treatment according to severity and systemic disease in carpal tunnel syndrome: a systematic review. Int J Environ Res Public Health. 2021;18(5):2365. doi:10.3390/ijerph18052365
  • Malakootian M, Soveizi M, Gholipour A, Oveisee M. Pathophysiology, diagnosis, treatment, and genetics of carpal tunnel syndrome: a review. Cell Mol Neurobiol. 2023;43:1817-1831. doi:10.1007/s10571-021-01297-2
  • Rotaru-Zavaleanu AD, Lungulescu CV, Bunescu MG, et al. Occupational carpal tunnel syndrome: a scoping review of causes, mechanisms, diagnosis, and intervention strategies. Front Public Health. 2024;12:1407302. doi:10.3389/fpubh.2024.1407302
  • Sivera V, Fani G, Fai A, et al. Safety and efficacy of ultrasound-guided perineural hydrodissection as a minimally invasive treatment in carpal tunnel syndrome: a systematic review. J Pers Med. 2024;14(2):154. doi: 10.3390/jpm14020154
  • Joshi A, Patel K, Shridevi SU, Varakantam V, Nagula P. Carpal tunnel syndrome: a review of the literature on the prevalence, diagnosis, and treatment. Cureus. 2022;14(7):e27053. doi:10.7759/cureus.27053
  • Tanrıverdi M, Hoşbay Z, Candan Algun Z. The relationship of pain on the upper extremity functions and quality of life in patients with carpal tunnel syndrome. J Back Musculoskelet Rehabil. 2019;32(1):71-76. doi: 10.3233/BMR-171097
  • Sarilar AÇ, Gök DK. Value of Boston Questionnaire in Carpal Tunnel Syndrome. Neurol Sci Neurophysiol. 2021;38(4):245-249. doi:10.4103/nsn.nsn_82_21
  • Tanrıverdi M, Hoşbay Z, Candan Algun Z. The relationship of pain on the upper extremity functions and quality of life in patients with carpal tunnel syndrome. J Back Musculoskelet Rehabil. 2019;32(1):71-76. doi: 10.3233/BMR-171097
  • Cetinkaya F, Karabulut N. Validity and reliability of the Turkish version of the Visual Analog Sleep Scale. Kontakt. 2016;18(2):e84-89. doi:10. 1016/j.kontakt.2016.05.003
  • Ullah U, Ahmad A, Shah S, et al. Exploring gender disparities in carpal tunnel syndrome: a comparative analysis of male-female ratios. Pak J Neurol Surg. 2024;28(2):177-183. doi:10.36552/pjns.v28i2.581
  • Hulkkonen S, Shiri R, Auvinen J, et al. Risk factors of hospitalization for carpal tunnel syndrome among the general working population. Scand J Work Environ Health. 2020;46(1):43-49. doi:10.5271/sjweh.3835
  • Mathew AE, John T. A clinical and neurophysiological analysis of idiopathic carpal tunnel syndrome with respect to gender and occupation. Ann Indian Acad Neurol. 2021;24(6):865-872. doi:10.4103/aian.AIAN_148_21
  • Nowak W, Znamirowska P, Szmigielska N, et al. Risk factors for carpal tunnel syndrome in patients with diabetes mellitus. J Pre-Clin Clin Res. 2023;12(2):1-6. doi:10.26444/jpccr/163676
  • Krzywdzak A, Wryych-Slusarska A, Krupa-Kotera K, et al. Bipolar pulsed radiofrequency neuromodulation of median nerve for treatment of carpal tunnel syndrome-a preliminary study. Ann Acad Med Stetin. 2021;75:107-110. doi:10.18388/ams.2021_75_107-110
  • Hofer M, Ranstam J, Atroshi I. Extended follow-up of local steroid injection for carpal tunnel syndrome: a randomized clinical trial. JAMA Netw Open. 2021;4(10):e2130753. doi:10.1001/jamanetworkopen.2021. 30753
  • Gupta H, Vance C, Bansal V, Siva A. A narrative review of pulsed radiofrequency for the treatment of carpal tunnel syndrome. Pain Pract. 2024;24(3):374-382. doi:10.1111/papr.12929
  • Chan PYW, Santana A, Alter T, et al. Long-term efficacy of corticosteroid injection for carpal tunnel syndrome: a systematic review. HAND. 2023; 20(3):463-473. doi:10.1177/15589447231222320
  • Ly-Pen D, Andreu JL, Millán I, et al. Long-term outcome of local steroid injection versus surgery in carpal tunnel syndrome: observational extension of a randomized clinical trial. Hand (N Y). 2022;17(4):639-645. doi:10.1177/1558944720944263
  • Gonu P, Butulu GC, Verma GG, et al. Effectiveness of ultrasound-guided local steroid injection to the wrist for the treatment of carpal tunnel syndrome: is it worth it? Egypt Rheumatol Rehabil. 2022;49:21. doi:10.1186/s43166-022-00121-5
  • Chakk R, Haskova J, Kautzner J. Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation. JACC Clin Electrophysiol. 2022;8(7):894-904. doi:10.1016/j.jacep.2022. 04.017
  • Carmo JD. 'INSIGHT-PRECISION': a new, mini-invasive technique for the surgical treatment of carpal tunnel syndrome. J Int Med Res. 2020; 48(2):1-16. doi:10.1177/0300060519874186
  • Kamel SI, Freid B, Pomeranz C, Halpern EJ, Nazarian LN. Minimally invasive ultrasound-guided carpal tunnel release improves long-term clinical outcomes in carpal tunnel syndrome. AJR Am J Roentgenol. 2021;217(2):460-468. doi:10.2214/AJR.20.24585
  • Alimohammadi E, Bagheri SR, Hadidi H, Rizevandi P, Abdi A. Carpal tunnel surgery: predictors of clinical outcomes and patients' satisfaction. BMC Musculoskeletal Disord. 2020;21:51. doi:10.1186/s12891-020-3082-2
  • Mertz K, Ho SAL, Mertz K, Kamal RN. Outcome measures in carpal tunnel syndrome: a systematic review. HAND (N Y). 2022;17(4):660-667. doi:10.1177/1558944720949951

USG görüntüleme rehberliğinde karpal tünel sendromu tedavisinde pulsed radyofrekans ile steroid enjeksiyonunun karşılaştırılması

Year 2025, Volume: 6 Issue: 4, 388 - 395, 31.08.2025
https://doi.org/10.47582/jompac.1747756

Abstract

Amaç: Karpal tünel sendromunun tedavisinde ultrasonografi kılavuzluğunda pulsed radyofrekans ve steroid enjeksiyonunun etkinliğini karşılaştırmak amaçlandı.
Yöntem: Bu retrospektif çalışmaya karpal tünel sendromu tanısı alan 60 hasta dahil edildi. Hastalar tedavi yöntemine göre iki gruba ayrıldı: 30 hastaya ultrasonografi kılavuzluğunda 40 mg metilprednizolon asetat enjeksiyonu, 30 hastaya ise ultrasonografi kılavuzluğunda 42°C'de 120 saniye süreyle median sinire pulsed radyofrekans uygulandı. VAS skoru, Boston Karpal Tünel Ölçeği, fizik muayene bulguları ve elektrofizyolojik parametreler tedavi öncesi, 1, 3 ve 6. aylarda değerlendirildi.
Sonuçlar: Başlangıçta, gruplar arasında demografik özellikler ve klinik parametreler açısından fark yoktu. Üçüncü ayda, VAS skoru pulsed radyofrekans grubunda 2,9±1,5'e düşerken, steroid grubunda 3,8±2,1 olarak kaldı (p=0,048). Boston ölçeğinin fonksiyonel skorları pulsed radyofrekans grubunda 1,6±0,7, steroid grubunda 2,0±0,8 idi (p=0,037). Altıncı ayda yapılan elektrofizyolojik değerlendirmede, motor distal latensi pulsed radyofrekans grubunda 3,9±0,7 ms ve steroid grubunda 4,3±0,8 ms idi (p=0,041). VAS skorunda %50'den fazla iyileşme oranı pulsed radyofrekans grubunda %80 ve steroid grubunda %60 idi.
Sonuç: Pulsed radyofrekans tedavisi, steroid enjeksiyonuna göre uzun vadede daha üstün sonuçlar vermektedir. Minimal invaziv bir yöntem olarak, cerrahi öncesi değerlendirilmelidir.

References

  • Osiak K, Elnazir P, Walocha JA, Pasternak A. Carpal tunnel syndrome: state-of-the-art review. Folia Morphol (Warsz). 2022;81(4):851-862. doi: 10.5603/FM.a2021.0121
  • Wietemborek PT, Kacprzak-Czapiewska K, Bartoszuk A, Kułakowski A. Carpal tunnel syndrome conservative treatment: a literature review. Adv Psychiatry Neurol. 2022;31(4):85-94. doi:10.5114/apn.2022.116889
  • Hernández-Secorún M, Montaña-Cortés R, Hidalgo-García C, et al. Effectiveness of conservative treatment according to severity and systemic disease in carpal tunnel syndrome: a systematic review. Int J Environ Res Public Health. 2021;18(5):2365. doi:10.3390/ijerph18052365
  • Malakootian M, Soveizi M, Gholipour A, Oveisee M. Pathophysiology, diagnosis, treatment, and genetics of carpal tunnel syndrome: a review. Cell Mol Neurobiol. 2023;43:1817-1831. doi:10.1007/s10571-021-01297-2
  • Rotaru-Zavaleanu AD, Lungulescu CV, Bunescu MG, et al. Occupational carpal tunnel syndrome: a scoping review of causes, mechanisms, diagnosis, and intervention strategies. Front Public Health. 2024;12:1407302. doi:10.3389/fpubh.2024.1407302
  • Sivera V, Fani G, Fai A, et al. Safety and efficacy of ultrasound-guided perineural hydrodissection as a minimally invasive treatment in carpal tunnel syndrome: a systematic review. J Pers Med. 2024;14(2):154. doi: 10.3390/jpm14020154
  • Joshi A, Patel K, Shridevi SU, Varakantam V, Nagula P. Carpal tunnel syndrome: a review of the literature on the prevalence, diagnosis, and treatment. Cureus. 2022;14(7):e27053. doi:10.7759/cureus.27053
  • Tanrıverdi M, Hoşbay Z, Candan Algun Z. The relationship of pain on the upper extremity functions and quality of life in patients with carpal tunnel syndrome. J Back Musculoskelet Rehabil. 2019;32(1):71-76. doi: 10.3233/BMR-171097
  • Sarilar AÇ, Gök DK. Value of Boston Questionnaire in Carpal Tunnel Syndrome. Neurol Sci Neurophysiol. 2021;38(4):245-249. doi:10.4103/nsn.nsn_82_21
  • Tanrıverdi M, Hoşbay Z, Candan Algun Z. The relationship of pain on the upper extremity functions and quality of life in patients with carpal tunnel syndrome. J Back Musculoskelet Rehabil. 2019;32(1):71-76. doi: 10.3233/BMR-171097
  • Cetinkaya F, Karabulut N. Validity and reliability of the Turkish version of the Visual Analog Sleep Scale. Kontakt. 2016;18(2):e84-89. doi:10. 1016/j.kontakt.2016.05.003
  • Ullah U, Ahmad A, Shah S, et al. Exploring gender disparities in carpal tunnel syndrome: a comparative analysis of male-female ratios. Pak J Neurol Surg. 2024;28(2):177-183. doi:10.36552/pjns.v28i2.581
  • Hulkkonen S, Shiri R, Auvinen J, et al. Risk factors of hospitalization for carpal tunnel syndrome among the general working population. Scand J Work Environ Health. 2020;46(1):43-49. doi:10.5271/sjweh.3835
  • Mathew AE, John T. A clinical and neurophysiological analysis of idiopathic carpal tunnel syndrome with respect to gender and occupation. Ann Indian Acad Neurol. 2021;24(6):865-872. doi:10.4103/aian.AIAN_148_21
  • Nowak W, Znamirowska P, Szmigielska N, et al. Risk factors for carpal tunnel syndrome in patients with diabetes mellitus. J Pre-Clin Clin Res. 2023;12(2):1-6. doi:10.26444/jpccr/163676
  • Krzywdzak A, Wryych-Slusarska A, Krupa-Kotera K, et al. Bipolar pulsed radiofrequency neuromodulation of median nerve for treatment of carpal tunnel syndrome-a preliminary study. Ann Acad Med Stetin. 2021;75:107-110. doi:10.18388/ams.2021_75_107-110
  • Hofer M, Ranstam J, Atroshi I. Extended follow-up of local steroid injection for carpal tunnel syndrome: a randomized clinical trial. JAMA Netw Open. 2021;4(10):e2130753. doi:10.1001/jamanetworkopen.2021. 30753
  • Gupta H, Vance C, Bansal V, Siva A. A narrative review of pulsed radiofrequency for the treatment of carpal tunnel syndrome. Pain Pract. 2024;24(3):374-382. doi:10.1111/papr.12929
  • Chan PYW, Santana A, Alter T, et al. Long-term efficacy of corticosteroid injection for carpal tunnel syndrome: a systematic review. HAND. 2023; 20(3):463-473. doi:10.1177/15589447231222320
  • Ly-Pen D, Andreu JL, Millán I, et al. Long-term outcome of local steroid injection versus surgery in carpal tunnel syndrome: observational extension of a randomized clinical trial. Hand (N Y). 2022;17(4):639-645. doi:10.1177/1558944720944263
  • Gonu P, Butulu GC, Verma GG, et al. Effectiveness of ultrasound-guided local steroid injection to the wrist for the treatment of carpal tunnel syndrome: is it worth it? Egypt Rheumatol Rehabil. 2022;49:21. doi:10.1186/s43166-022-00121-5
  • Chakk R, Haskova J, Kautzner J. Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation. JACC Clin Electrophysiol. 2022;8(7):894-904. doi:10.1016/j.jacep.2022. 04.017
  • Carmo JD. 'INSIGHT-PRECISION': a new, mini-invasive technique for the surgical treatment of carpal tunnel syndrome. J Int Med Res. 2020; 48(2):1-16. doi:10.1177/0300060519874186
  • Kamel SI, Freid B, Pomeranz C, Halpern EJ, Nazarian LN. Minimally invasive ultrasound-guided carpal tunnel release improves long-term clinical outcomes in carpal tunnel syndrome. AJR Am J Roentgenol. 2021;217(2):460-468. doi:10.2214/AJR.20.24585
  • Alimohammadi E, Bagheri SR, Hadidi H, Rizevandi P, Abdi A. Carpal tunnel surgery: predictors of clinical outcomes and patients' satisfaction. BMC Musculoskeletal Disord. 2020;21:51. doi:10.1186/s12891-020-3082-2
  • Mertz K, Ho SAL, Mertz K, Kamal RN. Outcome measures in carpal tunnel syndrome: a systematic review. HAND (N Y). 2022;17(4):660-667. doi:10.1177/1558944720949951
There are 26 citations in total.

Details

Primary Language English
Subjects Peripheral Nervous System
Journal Section Research Articles [en] Araştırma Makaleleri [tr]
Authors

Zeki Boğa 0000-0002-6387-5272

Mustafa Emre Saraç 0000-0001-8423-4266

Early Pub Date August 30, 2025
Publication Date August 31, 2025
Submission Date July 21, 2025
Acceptance Date August 4, 2025
Published in Issue Year 2025 Volume: 6 Issue: 4

Cite

AMA Boğa Z, Saraç ME. Comparison of pulsed radiofrequency and steroid injection in the treatment of carpal tunnel syndrome guided by USG imaging. J Med Palliat Care / JOMPAC / jompac. August 2025;6(4):388-395. doi:10.47582/jompac.1747756

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Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]



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