Jinekolojik malignite nedeniyle cerrahi uygulanan hastalarda senkron tümörlerin klinikopatolojik profili: retrospektif tek merkezli çalışma

Year 2025, Volume: 6 Issue: 5, 551 - 556, 24.10.2025

Işık Sözen , Gözde Şahin , Can Berk Karabudak , Aidana Sharip Kyzy , İlayda Aksoy , Yahya Özgün Öner , Başak Özge Kayan , Fatma Benli Tanrıkulu , Tolga Çiftpınar , İlkbal Temel

Abstract

Amaç: Bu çalışmanın amacı jinekolojik maligniteler nedeniyle ameliyat edilen kadınlarda senkron tümörlerin türlerini ve klinikopatolojik özelliklerini tanımlamaktı.
Yöntemler: Bu retrospektif tek merkezli çalışmaya patolojik olarak eş zamanlı tümör tanısı almış ardışık 20 hasta dahil edildi. Hastaların demografik verileri, HPV/sitoloji bulguları, cerrahi prosedürler, histopatolojik bulguları, tedavi tipleri ve erken dönem sonuçları (nüks, mortalite) incelendi ve analiz edildi.
Bulgular: Ortalama yaş 60,3 yıl ve ortalama BKİ 31,6 kg/m² idi. Hipertansiyon ve diyabet oranı her biri için %35 idi. Çoğu hastada HPV negatifti (%90); sitoloji %65'inde negatifti (anormallikler: ASC-US %20, ASC-H %5, HSIL %10). Hastaların %80'inde senkron endometrial ve over karsinomu (SEOC) gözlendi. Hastaların çoğunda endometrioid adenokarsinom vardı. SEOC hastaların %62,5'inde evre I-II tümörler vardı ve bu vakalarda tümörler arasındaki histolojik uyum %62,5 evreleme uyumu %75 idi.
Sonuç: SEOC, senkron tümörler arasında yüksek histolojik uyumla ön plana çıkmıştır. SEOC genellikle erken evrede tespit edilse de, hem histoloji hem de evreleme açısından senkron tümörler arasında önemli bir uyum vardı.

Keywords

senkron tümörler , endometrial kanser , over kanseri , endometrioid adenokarsinom , seröz karsinom

Clinicopathologic profile of synchronous tumors in patients undergoing surgery for gynecologic malignancy: a retrospective single-center study

Abstract

Aims: This study aimed to characterize tumor types and clinicopathological features of synchronous tumors in women operated for gynecologic malignancies.
Methods: This retrospective, single-center study included 20 consecutive patients with a pathological diagnosis of synchronous tumors. Patient demographics, HPV/cytology findings, surgical procedures, histopathological features, treatment modalities, and early outcomes (recurrence and mortality) were collected and analyzed.
Results: Mean age was 60.3 years and mean BMI was 31.6 kg/m². Hypertension and diabetes were each present in 35%. Most were HPV-negative (90%); cytology was negative in 65% (abnormalities: ASC-US 20%, ASC-H 5%, HSIL 10%). Synchronous endometrial and ovarian carcinoma (SEOC) was observed in 80% of the patients. The majority of patients had endometrioid adenocarcinoma (EAC). Among SEOC patients, 62.5% had stage I–II tumors. In these cases, histological concordance between synchronous tumors was 62.5%, while staging concordance was 75%.
Conclusion: SEOC predominated with high histologic concordance between synchronous tumors. Although SEOC is typically detected at an early stage, there was significant concordance between synchronous tumors in terms of both histology and staging.

Keywords

Synchronous tumors , endometrial cancer , ovarian cancer , endometrioid adenocarcinoma , serous carcinoma

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