Dişi ve erkek üreme sisteminde kisspeptinin rolü

Year 2024, , 31 - 39, 30.04.2024

Oya Korkmaz

https://doi.org/10.58651/jomtu.1454284

Abstract

Kisspeptin, gonadotropin salgılatıcı hormon (GnRH), lüteinizan hormon (LH) ve folikül uyarıcı hormon (FSH) sentezini kontrol etmekten sorumlu bir nöropeptittir. Etkilerini G-protein-bağlı reseptör 54/kisspeptin 1 reseptörü (GPR54/KISS1R) olarak bilinen G-protein-bağlı bir reseptör aracılığıyla gösterir. Kisspeptin ve etkilerinin anlaşılması, üreme biyolojisi alanında önemli bir atılımı temsil etmektedir. Kisspeptinler hem erkeklerde hem de kadınlarda üreme sisteminin gelişiminde ve optimal işleyişinde çok önemli bir rol oynamaktadır. Ayrıca ergenliğin başlamasında, geri bildirim süreçlerinin düzenlenmesinde ve cinsel istek ve uyarılmayı etkilemede rol oynar. Kadın üreme sisteminde, HPG ekseni aracılığıyla gebelik, emzirme, yumurtalık gelişimi, folikül gelişimi, oosit olgunlaşması ve yumurtlama gibi çeşitli süreçleri kontrol eder. Erkek üreme sisteminde ise Leydig hücreleri, spermatogenez, sperm fonksiyonu ve üreme davranışının düzenlenmesinde rol oynar. Araştırmalar, polikistik over sendromu (PCOS) ve infertilite gibi durumlarda kisspeptin düzensizliğinin patojenik önemini ortaya koymuştur. Kisspeptinin üreme ekseni üzerindeki etkisi ve ilişkili mekanizmaları hakkında fikir edinmek, kisspeptinin gelecekte hastalıkların tanı ve tedavisinde kullanılmasını kolaylaştıracaktır. Bu derleme, kisspeptinin hipotalamik-hipofiz-gonadal (HPG) eksen üzerindeki düzenleyici işlevine ve kisspeptinin hem kadınlarda hem de erkeklerde üreme süreçleri üzerindeki etkisine odaklanmaktadır.

Keywords

Kisspeptin, HPG ekseni, Üreme, İnfertilite

Ethical Statement

Ethics committee approval is not required for this study.

Supporting Institution

No financial support was received for the study.

Thanks

None.

The role of kisspeptin in female and male reproduction

Abstract

Kisspeptin is a neuropeptide responsible for controlling the synthesis of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The G-protein-coupled receptor 54/kisspeptin 1 receptor (GPR54/KISS1R) is involved in its action. The comprehension of kisspeptin and its actions represents a significant breakthrough in the field of reproductive biology. Kisspeptins play a crucial role in the development and optimal functioning of the reproductive system in both female and male. Additionally, it contributes to the onset of puberty, regulating feedback processes, and influencing sexual desire and arousal. It regulates a number of reproductive functions in women, including ovulation, lactation, ovarian development, follicle development, oocyte maturation, and pregnancy via the hypothalamic-pituitary-gonadal (HPG) axis. Spermatogenesis, sperm function, Leydig cells, and reproductive behaviour are all impacted by it in men. Infertility and polycystic ovarian syndrome (PCOS) are among the diseases linked to kisspeptin dysregulation, according to the research. For potential future use in diagnosing and treating problems, it may be helpful to understand the mechanisms behind kisspeptin's effects on the reproductive system. This review focuses on the regulatory function of kisspeptin on the HPG axis and the impact of kisspeptin on reproductive processes in both female and male.

Keywords

Kisspeptin, HPG axis, Reproduction, Infertility

Ethical Statement

Ethics committee approval is not required for this study.

Supporting Institution

No financial support was received for the study.

Thanks

None.

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