Propylthiouracil-Induced neutropenia coinciding with newly diagnosed Crohn’s disease

Abstract

Agranulocytosis is a serious side effect of antithyroid drugs (ATDs) in patients with hyperthyroidism. Diabetic ketosis is an acute complication of diabetes mellitus (DM) that can be triggered by conditions such as infection, stress, and noncompliance with treatment. Crohn’s disease (CD) is a chronic inflammatory disease of the digestive system and can present with life-threatening complications such as intestinal perforation. A 42-year-old woman with a history of DM, epilepsy, and hyperthyroidism presented with fatigue, sore throat, and joint pain. This is a rare case of Crohn’s disease diagnosed after an intestinal perforation during insulin infusion, plasmapheresis, and steroid therapy following diabetic ketoacidosis and neutropenia. This case highlights the coexistence of these three rare conditions in a single patient.

Keywords

• diabetic ketosis
• agranulocytosis
• neutropenia
• crohn's disease

Propiltiourasil tedavisine sekonder nötropeni ve Crohn hastalığı birlikteliği

Abstract

Agranülositoz, hipertroidi hastalarında antitiroid ilaçların (ATİ) kullanımına bağlı ortaya çıkan ciddi bir yan etkidir. Diyabetik ketoz, diyabetes mellitusun (DM) akut komplikasyonlarından biri olup, enfeksiyon, stres, tedavi uyumsuzluğu gibi durumlarla tetiklenebilir. Crohn hastalığı (CH), sindirim sisteminin kronik enflamatuvar bir hastalığı olup, intestinal perforasyon gibi hayatı tehdit eden komplikasyonlarla kendini gösterebilir. DM, epilepsi ve hipertroidi tanılı 42 yaşında kadın hasta halsizlik, boğaz ağrısı, eklem ağrısı şikâyeti ile başvurdu. Diyabetik ketoz ve nötropeni ile yatırılarak insülin infüzyonu, plazmaferez ve steroid tedavisi sırasında gelişen intestinal perforasyon sonucu crohn tanısı alan nadir bir olgudur. Bu olgu, nadir görülen bu üç durumun eş zamanlılığını vurgulamaktadır. Anahtar Kelimeler: Diyabetik ketoz, agranülositoz, nötropeni, crohn hastalığı

Keywords

• Diyabetik ketoz
• agranülositoz
• nötropeni
• chron hastalığı

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