WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH

Abstract

In order to find some clues as to why clozapine is a more effective drug than the sertindole and quetiapine, we investigated the molecular structures of these three molecules and calculated their structural properties by Density Functional Theory (DFT) technique. In this article, we suggested that clozapine has different binding possibilities depending on the dopamine level in the medium. If so, it can be understood why clozapine is more effective in resolving clinical problems caused by different dopamine levels in the frontal and subcortical regions. To test this hypothesis, we measured the binding of three drugs to D₁ and D₂ dopamine receptors by molecular docking. We found that clozapine had a greater potential for binding with D₁ and D₂ receptors. We suggested that this feature might give clozapine a higher therapeutic effect.

Keywords

• Dopamine,molecular docking,clozapine,schizophrenia

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