Research Article
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Year 2019, Volume: 2 Issue: 2, 207 - 215, 31.12.2019

Abstract

References

  • 1. Aranda R., Villalba K., Ravina E., Masaguer C.F., Brea J., Areias F., Dominguez E., Selent J., Lopez L., Sanz F., Pastor M. & Loza M.I. (2008). Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics. J. Med. Chem., 51(19), 6085-6094.
  • 2. Arnt J., Hyttel J. & Sánchez C. (1992). Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. European Journal of Pharmacology, 213(2), 259–267.
  • 3. Bayri A., Unal S., Altin S., Bulut F. & Dayanc B. E. (2016). Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis. Medical Hypotheses, 89, 84–88.
  • 4. Becke A. D. (1993). A new mixing of Hartree–Fock and local density‐functional theories. The Journal of Chemical Physics, 98(2), 1372–1377.
  • 5. de Keyser J., De Backer J.-P., Vauquelin G. & Ebinger G. (1990). The effect of aging on the D1 dopamine receptors in human frontal cortex. Brain Research, 528(2), 308–310.
  • 6. Devoto P., Flore G., Vacca G., Pira L., Arca A., Casu M. A., Pani L. & Gessa G. L. (2003). Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology, 167(1), 79–84.
  • 7. Khokhar J. Y., Henricks A. M., Sullivan E.D.K. & Green A.I. (2018). Unique Effects of Clozapine: A Pharmacological Perspective. Advances in Pharmacology (San Diego, Calif.), 82, 137–162.
  • 8. Lee C., Yang W. & Parr R. G. (1988). Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Physical Review B, 37(2), 785–789.
  • 9. Perreault M. L., O’Dowd B.F. & George S.R. (2011). Dopamine receptor homooligomers and heterooligomers in schizophrenia. CNS Neuroscience & Therapeutics, 17(1), 52–7.
  • 10. Qin S., Hermans E. J., van Marle H.J.F., Luo J. & Fernández G. (2009). Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex. Biological Psychiatry, 66(1), 25–32.
  • 11. Salmas R.E., Is Y.S., Durdagı S., Stein M. & Yurtsever M. (2018). A QM protein–ligand investigation of antipsychotic drugs with the dopamine D2 Receptor (D2R). Journal of Biomolecular Structure and Dynamics, 36, 2668-2677.
  • 12. Siskind D., McCartney L., Goldschlager R. & Kisely S. (2016). Clozapine v. first- and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis. British Journal of Psychiatry, 209(05), 385–392.
  • 13. Tauscher J., Hussain T., Agid O., Verhoeff N.P.L.G., Wilson A. A., Houle S., Remington G., Zipursky R.B. & Kapur S. (2004). Equivalent Occupancy of Dopamine D 1 and D 2 Receptors With Clozapine: Differentiation From Other Atypical Antipsychotics. American Journal of Psychiatry, 161(9), 1620–1625.
  • 14. Thomas T., Fang Y., Yuriev E. & Chalmers D. (2016). Ligand Binding Pathways of Clozapine and Haloperidol in the Dopamine D2 and D3 Receptors. J. Chem. Inf. Model., 56(2), 308-321.
  • 15. URL-1 (2019). https://pubchem.ncbi.nlm.nih.gov/compound, National Center for Biotechnology Information. PubChem Database.
  • 16. Yang W., Parr R. G. & Lee C. (1986). Various functionals for the kinetic energy density of an atom or molecule. Physical Review A, 34(6), 4586–4590.

WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH

Year 2019, Volume: 2 Issue: 2, 207 - 215, 31.12.2019

Abstract

In order to find some clues as to why clozapine is a
more effective drug than the sertindole and quetiapine, we investigated the
molecular structures of these three molecules and calculated their structural
properties by Density Functional Theory (DFT) technique. In this article, we
suggested that clozapine has different binding possibilities depending on the
dopamine level in the medium. If so, it can be understood why clozapine is more
effective in resolving clinical problems caused by different dopamine levels in
the frontal and subcortical regions. To test this hypothesis, we measured the
binding of three drugs to D1 and D2 dopamine receptors by
molecular docking. We found that clozapine had a greater potential for binding
with D1 and D2 receptors. We suggested that this feature
might give clozapine a higher therapeutic effect.

References

  • 1. Aranda R., Villalba K., Ravina E., Masaguer C.F., Brea J., Areias F., Dominguez E., Selent J., Lopez L., Sanz F., Pastor M. & Loza M.I. (2008). Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics. J. Med. Chem., 51(19), 6085-6094.
  • 2. Arnt J., Hyttel J. & Sánchez C. (1992). Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. European Journal of Pharmacology, 213(2), 259–267.
  • 3. Bayri A., Unal S., Altin S., Bulut F. & Dayanc B. E. (2016). Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis. Medical Hypotheses, 89, 84–88.
  • 4. Becke A. D. (1993). A new mixing of Hartree–Fock and local density‐functional theories. The Journal of Chemical Physics, 98(2), 1372–1377.
  • 5. de Keyser J., De Backer J.-P., Vauquelin G. & Ebinger G. (1990). The effect of aging on the D1 dopamine receptors in human frontal cortex. Brain Research, 528(2), 308–310.
  • 6. Devoto P., Flore G., Vacca G., Pira L., Arca A., Casu M. A., Pani L. & Gessa G. L. (2003). Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology, 167(1), 79–84.
  • 7. Khokhar J. Y., Henricks A. M., Sullivan E.D.K. & Green A.I. (2018). Unique Effects of Clozapine: A Pharmacological Perspective. Advances in Pharmacology (San Diego, Calif.), 82, 137–162.
  • 8. Lee C., Yang W. & Parr R. G. (1988). Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Physical Review B, 37(2), 785–789.
  • 9. Perreault M. L., O’Dowd B.F. & George S.R. (2011). Dopamine receptor homooligomers and heterooligomers in schizophrenia. CNS Neuroscience & Therapeutics, 17(1), 52–7.
  • 10. Qin S., Hermans E. J., van Marle H.J.F., Luo J. & Fernández G. (2009). Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex. Biological Psychiatry, 66(1), 25–32.
  • 11. Salmas R.E., Is Y.S., Durdagı S., Stein M. & Yurtsever M. (2018). A QM protein–ligand investigation of antipsychotic drugs with the dopamine D2 Receptor (D2R). Journal of Biomolecular Structure and Dynamics, 36, 2668-2677.
  • 12. Siskind D., McCartney L., Goldschlager R. & Kisely S. (2016). Clozapine v. first- and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis. British Journal of Psychiatry, 209(05), 385–392.
  • 13. Tauscher J., Hussain T., Agid O., Verhoeff N.P.L.G., Wilson A. A., Houle S., Remington G., Zipursky R.B. & Kapur S. (2004). Equivalent Occupancy of Dopamine D 1 and D 2 Receptors With Clozapine: Differentiation From Other Atypical Antipsychotics. American Journal of Psychiatry, 161(9), 1620–1625.
  • 14. Thomas T., Fang Y., Yuriev E. & Chalmers D. (2016). Ligand Binding Pathways of Clozapine and Haloperidol in the Dopamine D2 and D3 Receptors. J. Chem. Inf. Model., 56(2), 308-321.
  • 15. URL-1 (2019). https://pubchem.ncbi.nlm.nih.gov/compound, National Center for Biotechnology Information. PubChem Database.
  • 16. Yang W., Parr R. G. & Lee C. (1986). Various functionals for the kinetic energy density of an atom or molecule. Physical Review A, 34(6), 4586–4590.
There are 16 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Süheyla Ünal

Mustafa Karakaplan

Erdinç Öz

İsmet Yılmaz This is me

Serdar Altın This is me

Ali Bayri

Publication Date December 31, 2019
Published in Issue Year 2019 Volume: 2 Issue: 2

Cite

APA Ünal, S., Karakaplan, M., Öz, E., Yılmaz, İ., et al. (2019). WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH. Bartın University International Journal of Natural and Applied Sciences, 2(2), 207-215.
AMA Ünal S, Karakaplan M, Öz E, Yılmaz İ, Altın S, Bayri A. WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH. JONAS. December 2019;2(2):207-215.
Chicago Ünal, Süheyla, Mustafa Karakaplan, Erdinç Öz, İsmet Yılmaz, Serdar Altın, and Ali Bayri. “WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH”. Bartın University International Journal of Natural and Applied Sciences 2, no. 2 (December 2019): 207-15.
EndNote Ünal S, Karakaplan M, Öz E, Yılmaz İ, Altın S, Bayri A (December 1, 2019) WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH. Bartın University International Journal of Natural and Applied Sciences 2 2 207–215.
IEEE S. Ünal, M. Karakaplan, E. Öz, İ. Yılmaz, S. Altın, and A. Bayri, “WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH”, JONAS, vol. 2, no. 2, pp. 207–215, 2019.
ISNAD Ünal, Süheyla et al. “WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH”. Bartın University International Journal of Natural and Applied Sciences 2/2 (December 2019), 207-215.
JAMA Ünal S, Karakaplan M, Öz E, Yılmaz İ, Altın S, Bayri A. WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH. JONAS. 2019;2:207–215.
MLA Ünal, Süheyla et al. “WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH”. Bartın University International Journal of Natural and Applied Sciences, vol. 2, no. 2, 2019, pp. 207-15.
Vancouver Ünal S, Karakaplan M, Öz E, Yılmaz İ, Altın S, Bayri A. WHY IS CLOZAPINE MORE EFFECTIVE THAN OTHER ATYPICAL ANTIPSYCHOTICS? DENSITY FUNCTIONAL THEORY AND MOLECULAR DOCKING APPROACH. JONAS. 2019;2(2):207-15.