Serum galectin-3 levels and vitamin D relationship in heart failure

Abstract

Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis. Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency. We examined the relationship between the stage of heart failure and galectin-3 and 25-OH vitamin D levels. Methods: Sixty patients with heart failure and 30 healthy volunteers were included in this prospective case-control study. Demographic data, comorbid diseases and laboratory data were examined, and 25-OH vitamin D and galectin-3 levels were compared between the patients with CHF and the control group. Results: Galectin-3 levels were high in patients with heart failure (P<0.001) and increased as the ejection fraction (EF) decreased (P=0.001). 25-OH vitamin D levels were lower in the patient group compared to the control group (P<0.001). There was no significant correlation between serum galectin-3 and vitamin D levels (r=-0.22; P=0.094); however, serum galectin-3 levels and the stage of CHF were correlated (r=0.66; P=0.001). Conclusions: We found high serum galectin-3 levels in patients with heart failure and low 25 OH vitamin D levels. We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.

Keywords

• Galectin 3
• Congestive heart failure
• Vitamin D3 level

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