Esansiyel trombositozlu hastalarda trombozu etkileyen risk faktörlerinin değerlendirilmesi

Öz

Amaç: Esansiyel trombositozda (ET) arteriyel ve venöz tromboembolik komplikasyonlar morbidite ve mortalitenin en önemli nedenlerdir. ET'de tromboz mekanizması tam olarak açıklanamamıştır. Mevcut retrospektif analizde, ET'li hastalarda tromboz komplikasyonu ile yaş, cinsiyet, hastalık süresi, laboratuvar bulguları, janus kinaz 2 (JAK2) V617F mutasyon durumu arasındaki ilişkiyi araştırmayı amaçladık.

Yöntemler: Nisan 2015 ile Nisan 2017 arasında kurumumuzun kliniğine başvuran ET hastalarının dosyaları retrospektif olarak analiz edildi. Hastalar arteriyel-venöz tromboz öyküsü olan ve olmayan olarak iki gruba ayrıldı. Tromboz öyküsüne göre, grupların genel özellikleri, laboratuvar bulguları ve JAK2 V617F mutasyon durumu karşılaştırıldı.

Bulgular: Tromboz öyküsü olan 37 hasta ve tromboz öyküsü olmayan 15 hasta tespit edildi. Tromboz öyküsü olan ET hastalarında lökosit, trombosit ve lenfosit sayısı tromboz öyküsü olmayan hastalardan istatistiksel olarak anlamlı yüksekti. Tromboz öyküsü olan ET hastalarında JAK2 V617F mutasyon pozitifliği istatistiksel olarak anlamlı idi.

Sonuç: Bu çalışma, ET'li hastalarda tromboz riski faktörü olarak yüksek lökosit sayısı, yüksek trombosit ve lenfosit sayısı ve JAK2 V617F mutasyon pozitifliğini doğrulamıştır. Ayrıca kliniğimize başvuran hastaların özellikleri literatürle karşılaştırıldı, benzerlikler ve farklılıklar karşılaştırıldı.

Anahtar Kelimeler

• Janus kinaz 2 mutasyonu,Tromboz hikayesi,Esansiyel trombositoz,Lökosit sayısı,Trombosit sayısı

Assessment of risk factors affecting thrombosis in patients with essential thrombocytosis

Abstract

Aim: Arterial and venous thromboembolic complications are the leading cause of morbidity and mortality in Essential thrombocytosis (ET). The mechanism of thrombosis in ET is not fully explained. In present retrospective analysis, we aimed to investigate the association between thrombosis complication and age, gender, disease duration, laboratory findings, janus kinase 2 (JAK2) V617F mutation status in patients with ET.

Methods: Medical database of ET patients whom admitted to outpatient clinics of our institution, between April 2015 and April 2017, were retrospectively analyzed. Patients were divided into two groups, with and without arterial or venous thrombosis history. According to the thrombosis story, general characteristics, laboratory findings and JAK2 V617F mutation status of the groups were compared.

Results: 37 patients with thrombosis history and 15 patients without thrombosis history were detected. The number of leukocyte, platelet and lymphocyte in ET patients with thrombosis history was statistically significantly higher than without thrombosis history patients. JAK2 V617F mutation positivity was statistically significant in ET patients with thrombosis history.

Conclusion: This study confirmed the high leukocyte count, high platelet and lymphocyte count and JAK2 V617F mutation positivity as the thrombosis risk factor in patients with ET. In addition, the characteristics of the patients who applied to our clinic were compared with the literature and the differences were revealed.

Keywords

• Thrombosis history,Essential thrombocytosis,Janus kinase 2 mutation,Leukocyte count,Platelet count

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