Obstruktif uyku apne sendromu cerrahisinden sonra nötrofil/lenfosit oranı, ortalama tombosit hacmi ve trombosit/ lenfosit oranlarının preoperatif ve postoperatif erken ve geç dönemdeki değişimi

Öz

Amaç: Bu çalışmada Obstrüktif uyku apne sendromu (OUAS) şiddeti ile Nötrofil Lenfosit oranı (NLO), Trombosit Lenfosit oranı (TLO) ve Ortalama Trombosit Hacmi (OTH) arasındaki ilişki ve bu hastaların preoperatif ve postoperatif erken ve geç dönemdeki düzeyleri, cerrahiye bağlı değişimleri araştırıldı. 

Yöntemler: OUAS tanısı konmuş ve tedavi amacıyla cerrahi operasyon yapılmış toplam 148 hasta ( 22 kadın %14.9 ve 126 erkek %85.1 ) çalışmaya alındı. Hastalar apne hipoapne indeksine (AHİ) göre hafif-orta OUAS’lı hastalar ( 86 (%58.1 ) ), (AHİ:5-15 Hafif OUAS, AHİ:15-30 Orta OUAS ) ve Ağır OUAS’lı ( 62 (%41.9) ) hastalar olarak iki gruba ayrıldı. Retrospektif olarak hastaların kan sonuçları tarandı ve preoperatif, postopertif erken ve geç dönem tam kan sonuçları incelendi. 

Bulgular: Kilo ve BMI değerleri Ağır OUAS grubunda yüksek saptandı. Hafif-Orta OUAS ile Ağır OUAS grupları, NLO, TLO ve OTH değerleri preoperatif, erken ve geç postoperatif dönemler, gruplar arası karşılaştırıldığında anlamlı fark bulunmadı. Grup içi karşılaştırmada ise her iki grupta da NLO’da ve TLO’da postoperatif erken dönemde artış saptandı. OTH değerler arasında fark bulunmadı. Postoperatif geç dönemde NLO düzeyleri preoperatif değerlere düşerken, TLO düzeyleri preoperatif değerlere göre yükseklik devam etmekte idi.

Sonuç: Sistemik inflamasyonun belirteci olarak kullanılan NLO, TLO ve OTH değerlerinin Hafif-Orta ve Ağır OUAS grupları arasında benzer olması ve hava yolu tıkanıklığının giderilmesine rağmen değişmeyişi bu hastalıktaki oksidatif stres ve sistemik inflamasyonun hava yolu tıkanıklığının yanı sıra çok çeşitli faktörlere bağlı olduğunu düşündürmektedir.

Anahtar Kelimeler

• Obstruktif uyku apne sendromu,Nötrofil lenfosit oranı,Trombosit lenfosit oranı,Ortalama trombosit hacmi

After obstructive sleep apnea syndrome surgery, preoperative, postoperative early and late change of neutrophil / lymphocyte ratio, platelet / lymphocyte ratio and mean platelet volume

Abstract

Aim: The aim of this study was to investigate the relationship between the severity of obstructive sleep apnea syndrome (OSAS), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and mean platelet volume (MPV), preoperative and postoperative early and late levels of these patients surgery related changes were investigated. Methods: A total of 148 patients (22 women, 14.9% and 126 men, 85.1%) who underwent OSA diagnosis and surgical treatment were included in the study. Patients with mild to moderate OSAS [86 (58.1%)], and severe OSAS [62 (41.9%)] patients with apnea hypoapnea index. (OSAS: 5-15 mild OSAS, AHI: 15-30, severe OSAS AHİ 30>) Patients were divided into two groups. Retrospectively, the blood results of these patients were investigated and preoperative, postoperative early and late full blood results were examined. Results: Weight and BMI values were found to be high in the heavy OSAS group. There was no significant difference between mild-moderate OSAS and severe OSAS groups, preoperative, early and late postoperative periods, and between NLR, PLR and MPV values. Intra-group comparison showed an increase in NLR and PLR in the early postoperative period in both groups. There was no difference between the other values. In late postoperative period, NLR levels decreased to preoperative values while PLR levels were higher than preoperative values. Conclusion: The similarity of NLR, PLR, and MPV values between the mild-moderate and severe OSAS groups as a marker of systemic inflammation and the fact that airway obstruction was remained unchanged suggests that oxidative stress and systemic inflammation in this disease are due to a variety of factors besides airway obstruction.

Keywords

• Obstructive sleep apnea syndrome
• Neutrophil lymphocyte ratio
• Platelet lymphocyte ratio
• Mean platelet volume

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