Rozasea ve D vitamini düzeyleri üzerinde bir vaka kontrol çalışması

Öz

Amaç: Rozasea yüz bölgesinde geçici eritem (flushing), kalıcı eritem, papül, püstül ve telenjiektazi gibi çeşitli özelliklerle karakterize olan kronik inflamatuvar bir dermatozdur Bu çalışmada amacımız rozasea patogenezine etki edebilecek serum vitamin D düzeylerinin rolünü araştırmaktır.

Yöntemler: Dermatoloji polikliniğine başvuran 50 rozasea hastası ile yaş ve cinsiyet açısından eşleştirilmiş 50 sağlıklı kontrol grubu alındı. Rozasealı hastalarda ve kontrol grubunda serum paratiroid hormonu (PTH), D vitamin seviyeleri, serum kalsiyum düzeyleri ölçüldü ve istatistiksel olarak karşılaştırıldı.

Bulgular: Rozasealı hasta grubunun serum 25-hidroksivitamin D düzeyi medianı 10,55 (6,30-38,60) ng/ml, kontrol grubunun ise 8,50 (4,50-25,60) ng/ml olarak saptandı. Rozasea’lı hasta grubunun serum vitamin D düzeyi kontrol grubundan anlamlı olarak yüksek bulundu (p=0,013). Rozasealı hasta grubunun serum kalsiyum düzeyi medianı 8,20 (7,20-9,20) mg/dl, kontrol grubunun ise 8,55(7,60-11,40) mg/dl olarak saptandı. Kontrol grubunun serum kalsiyum düzeyi rozasealı hasta grubundan anlamlı olarak yüksek bulundu (p=0,000). Rozasealı hasta grubu ve kontrol grubu arasında serum parathormon düzeyleri açısından istatistiksel olarak anlamlı farklılık saptanmadı (p=0,194).

Sonuç: Serum vitamin D düzeylerinin yükselmesi rozasea gelişimi ile ilişkili olabilir.

Anahtar Kelimeler

• Rozasea,Vitamin D,Katelisidin,Parathormon

A case-control study on rosacea and vitamin D levels

Abstract

Aim: Rosacea is a chronic inflammatory dermatosis characterized by several features such as temporary erythema (flushing), permanent erythema, papules, pustules and telangiectasia in the face. In this study, our aim is to investigate the role of serum vitamin D levels in the pathogenesis of rosacea. 

Methods: 50 patients with rosacea and 50 age and gender matched healthy controls were included in this study. In patients with rosacea and control group, serum parathyroid hormone (PTH), vitamin D levels and serum calcium levels were measured and the results were compared statistically. 

Results: Serum vitamin D levels in patients with rosacea were significantly higher than the control group (respectively 10,55 ng/ml and 8,50 ng/ml). The median of serum calcium level was found to be 8,20 mg/dl in the group of patients with rosacea and 8,55 mg/dl in the control group. Serum calcium levels of the control group were significantly higher than the group of patients with rosacea. There was no statistically significant difference in terms of serum parathormone levels between the group of patients with rosacea and control group. The increase in serum vitamin D levels may lead development of rosacea. 

Conclusion: As a result, the increase in serum vitamin D levels is associated with rosacea.

Keywords

• Rosacea,Vitamin D,Cathelicidin,Parathormone

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