Monosit HDL-kolesterol oranı ile mitral annülüs kalsifikasyonu arasındaki ilişki

Öz

Amaç: Mitral annülüs kalsifikasyonu (MAK) mitral kapak annülüsünün dejeneratif kalsifikasyonu ile karakterizedir, MAK ve ateroskleroz risk faktörleri ve patogenez bakımından benzer özellikler taşır. Monosit sayısının yüksek dansiteli lipoproteine (HDL) oranı (MHO) birçok aterosklerotik hastalıkla ilişkili bir inflamatuvar belirteçtir. Biz MAK varlığı ile MHO derecesinin ilişkisini ortaya koymayı amaçladık.

Yöntemler: Bu retrospektif kohort çalışma ekokardiyografi laboratuvarımıza başvurmuş 245 [MAK(+) 200 çalışma grubu hastası, MAK(-) 45 kontrol grubu hastası] ile yapılmıştır. Grupların demografik özellikleri; yaş, hipertansiyon ve diyabetes mellitus varlığı açısından benzerdi. Tümünün laboratuvar ve ekokardiyografik parametreleri değerlendirildi.

Bulgular: Gruplar ekokardiyografik veriler olan sol atriyum çapı, pulmoner arter sistolik basıncı (PASB) açısından karşılaştırıldığında MAK varlığı ile pozitif yönde ilişkili saptandı(sırasıyla, r=0,271, p<0,001; r=0,329, p<0,001). Monosit HDL kolesterol oranı, MAK (+) grupta MAK (-) ruba göre istatistiksel olarak anlamlı derecede yüksekti {15,3 (11,9-20,6) vs. 10,8 (8,6-16,9) p<0,001}. Korelasyon analizine göre Monosit HDL oranı MAK varlığıyla anlamlı olarak ilişkili saptandı (r=0,273; p<0.001).

Sonuç: Sonuçlarımız MAK bulunan hastalarda MHO’nun anlamlı derecede yüksek olduğunu ve MAK ile MHO‘nun anlamlı derecede körele olduğunu ortaya koymuştur.

Anahtar Kelimeler

• Mitral annülüs kalsifikasyonu,Monosit,HDL

Association between monocyte to HDL cholesterol ratio and mitral annulus calcification

Abstract

Aim: Mitral annulus calcification (MAC) is characterized by degenerative calcification of the mitral valve annulus, MAC and atherosclerosis are similar in regard to risk factors and pathogenesis. Monocyte count to high density lipoprotein (HDL) cholesterol ratio (MHR) is an inflammatory marker that is associated with several atherosclerotic diseases. We aimed to show the association of MHR levels with the presence of MAC.

Methods: This retrospective cohort study was conducted with MAC (+) patients who admitted to our echocardiography laboratory which constituted the study group (n=200) and MAC (-) patients which constituted the control group. Demographic features like age and sex, presence of hypertension and diabetes mellitus were similar between groups. Laboratory and echocardiographic parameters were recorded and evaluated for statistical analysis.

Results: When groups were compared according to echocardiographic parameters; left atrial diameter, pulmonary artery systolic pressure (PASP) were found to be positively correlated with the presence of MAC (r=0.271, p<0.001; r=0.329, p<0.001, respectively). MHR was significantly higher in study group {15.3 (11.9-20.6) vs. 10.8 (8.6-16.9) p<0.001}. In correlation analysis, MHR value was found to be positively correlated with presence of MAC (r=0.273; p <0.001).

Conclusion: We found that the presence of MAC was associated with higher MHR, and MHR was significantly correlated with MAC.

Keywords

• Mitral annulus calcification,Monocyte,HDL

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