Preoperatif nötrofil–lenfosit oranı ile lenf nodu metastazı olan differansiye tiroid karsinomu arasındaki ilişkinin değerlendirilmesi

Abstract

Amaç: Sistemik inflamatuar yanıtın tümör gelişimi, ilerlemesi ve metastazının tüm aşamalarında kritik bir rol oynadığı gösterilmiştir. Yüksek nötrofil lenfosit oranının (NLO), tümörlerin kötü prognozunun bir göstergesi olduğu düşünülmektedir. Bu çalışmada, preoperatif NLO ile diferansiye tiroid karsinomunun (DTC) lenf nodu metastazı arasındaki ilişkiyi araştırdık. 

Yöntemler: Çalışmaya tiroid cerrahisi sonrası patoloji sonuçlarına göre DTC tanısı alan toplam 74 hasta alındı. NLO, tam kan sayımındaki mutlak nötrofil sayısının lenfosit sayısına bölünmesiyle belirlenmiştir. En uygun cut-off değeri ROC eğrisi ile tahmin edilmiştir. Çalışma cross-sectional olarak dizayn edildi. 

Bulgular: %95 confidence interval ile eğri altında kalan alan 0,620 olan analizde olabilirlik oranı 3,2 olarak hesaplandığında %44,4 sensivite ve %86,2 spesifite ile NLR için cut-off değer 2,59 olduğu saptandı. Mevcut cut-off değeri ile DTC'nin lenf nodu metastazı arasında anlamlı bir ilişki vardı (P=0,03). 

Sonuç: NLO lenf nodu pozitif diferansiye tiroid kanserlerinde anlamlı olarak yüksek bulundu. İnflamatuar indeks olarak nötrofil lenfosit oranı, diferansiye tiroid karsinomu olan hastalar için ucuzdur, kolay kullanılabilir ve rutin kan testlerinden elde edilmesi kolaydır.

Keywords

• Nötrofil,Lenfosit,Tiroid,Karsinom

Evaluation of preoperative neutrophil-lymphocyte ratio in differentiated thyroid carcinoma with lymph node metastasis

Abstract

Aim: Systemic inflammatory response has been shown to play a critical role in all stages of tumor development, progression and metastasis. High neutrophil lymphocyte ratio (NLR) is thought to be an indicator of poor prognosis of tumors. In this study, we investigated the relationship between preoperative NLR and lymph node metastasis of differentiated thyroid carcinoma (DTC). 

Methods: The study included a total of 74 patients diagnosed with DTC according to pathology results after thyroid surgery. The NLR was determined by dividing the absolute neutrophil count in the whole blood count by the lymphocyte count. Optimal cut-off value was estimated by means of ROC curve. The study was designed a cross-sectional study.

Results: With a 95% confidence interval, the area under the curve of 0.620 and the likelihood ratio of 3.2, the cut-off value for NLR was found to be 2.59 with 44.4% sensitivity and 86.2% specificity, respectively. There was a significant relationship between the current cut off value and the lymph node metastasis of DTC (P=0.03). 

Conclusion: NLR was found to be significantly increased in lymph node-positive differentiated thyroid cancers. The neutrophil to lymphocyte ratio as an inflammation index is inexpensive for patients with differentiated thyroid carcinoma, easily available and easy to obtain from routine blood tests.

Keywords

• Neutrophil,Lymphocyte,Thyroid,Carcinoma

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