The management of clinically early ovarian cancer patients who have not undergone staging surgery

Abstract

Four-thirds of patients with epithelial ovarian cancer are diagnosed at an advanced stage, and the main choice of treatment is primary cytoreductive surgery followed by adjuvant platinum-based chemotherapy, or interval surgery after neoadjuvant chemotherapy in patients who are not eligible for optimal cytoreductive surgery. In patients with disease clinically confined to the ovary, The International Federation of Gynecology and Obstetrics (FIGO) recommends comprehensive staging to detect the real stage of the disease, but some these patients do not undergo staging during operation. Retrospective studies in the literature report that re-operation, adjuvant chemotherapy without re-operation or observation are some of the management options during the postoperative period for patients with clinically early stage disease. In this article, the management of these patients was reviewed in light of the current literature.

Keywords

• Staging surgery,Chemotherapy,Ovarian carcinoma,Observation,Incomplete surgery

Evreleme ameliyatı geçirmemiş klinik olarak erken over kanseri hastalarının yönetimi

Öz

Epitelyal over kanseri olan hastaların dörtte üçüne ileri evrede iken tanı konur ve bu hastaların ana tedavisi primer sitoredüktif cerrahi, ardından adjuvan platin bazlı kemoterapi veya neoadjuvan kemoterapi sonrası sitoredüktif cerrahidir. Klinik olarak overde sınırlı hastalığı olan kadınlarda, Uluslararası Kadın Hastalıkları ve Doğum Federasyonu (FIGO) hastalığın gerçek evresinin tespiti için kapsamlı evreleme cerrahisi yapılmasını önermektedir, ancak bu hastalardan bazıları operasyon sırasında evreleme ameliyatı geçirmemiş olabilir. Literatürdeki retrospektif çalışmalara göre, klinik olarak erken evre hastalığı olan bu hastalar için tekrar ameliyat, tekrar ameliyat olmadan adjuvan kemoterapi veya gözlem tedavi seçenekleri olarak uygulanmaktadır. Bu yazıda, cerrahi evrelemesi yapılmamış bu hastaların yönetimi güncel literatür ışığında gözden geçirilmiştir.

Anahtar Kelimeler

• Cerrahi evreleme,Kemoterapi,Over kanseri,Gözlem,Tamamlanmamış cerrahi

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