Research Article
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Etiology of anemia in children aged between 6 months and 18 years

Year 2019, , 402 - 405, 28.05.2019
https://doi.org/10.28982/josam.568900

Abstract

Aim: Anemia is an important public health problem that concerns human and community health. In this study, we aimed to determine the etiology of anemia in different age groups and create social awareness.

Methods: The study (retrospective cohort study) included anemia patients between 6 months and 18 years old who applied to the Pediatric Hematology and Oncology Outpatient Clinic of KSU Medical Faculty between January 2015 and January 2018.

Results:1120 patients were included in the study. There were 873 with iron deficiency anemia, 184 with thalassemia minor, 25 with vitamin B12 deficiency anemia, 13 with autoimmune hemolytic anemia, 10 with hereditary spherocytosis and the other etiology of anemia. While 16.4% of all patients and 33.8% of patients aged 6-12 years had thalassemia minor. On the other side, 81.3% of patients aged 6 months-2 years, 74.3% of patients aged 2-6 years, 60.4% of patients aged 6-12 years and 85.0% of patients aged 12-18 years had iron-deficiency anemia. Iron deficiency anemia was common in males (60.2%) in the 2-6 years age group (P=0.002), but it was common in females (80.6%) in the 12-18 years age group (P<0.001). 

Conclusion: As a result of this study, it has been concluded that screening and iron supplementation should be done in societies at risk.

Supporting Institution

The authors declared that this case has received no financial support.

References

  • 1. Akca SO, Bostanci MÖ. The impact of anemia and body mass index (BMI) on neuromotor development of preschool children. Rev Assoc Med Bras. 2017;63(9):779-86.
  • 2. Janus J, Moerschel, SK. Evaluation of anemia in children. Am. Fam. Physician 2010;81(12):1462-71.
  • 3. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007;370:511-20.
  • 4. Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood. Am J Clin Nutr. 2006;84(6):1261-76.
  • 5. Lisboa MBMC, Oliveira EO, Lamounier JA, Silva CAM, Freitas RN. Prevalence of iron-deficiency anemia in children aged less than 60 months: A population-based study from the state of Minas Gerais, Brazil. Rev Nutr. 2015;28(2):121-31.
  • 6. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, etal. Global, regional, and national trends in hemoglobin concentration and prevalence of total and severe Anemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1:e16–25.
  • 7. Akkermans MD, Eussen SR, van der Horst-Graat JM, van Elburg RM, van Goudoever JB, Brus F. A micronutrient-fortified young-child formula improves the iron and vitamin D status of healthy young European children: a randomized, double-blind controlled trial. Am J Clin Nutr. 2017;105(2):391-9.
  • 8. Irwin JJ, Kirchner JT. Anemia in children. Am Fam Physician. 2001;64(8):1379-86.
  • 9. Zuffo CR, Osório MM, Taconeli CA, Schmidt ST, da Silva BH, Almeida CC. Prevalence and risk factors of anemia in children. J Pediatr (Rio J). 2016;92(4):353-60.
  • 10. Balcı YI, Karabulut A, Gürses D, Çövüt IE. Prevalence and risk factors of anemia among adolescents in Denizli, Turkey. Iran J Pediatr. 2012;22(1):77-81.
  • 11. Balarajan YS, Fawzi WW, Subramanian SV. Changing patterns of social inequalities in Anemia among women in India: crosssectional study using nationally representative data. BMJ Open. 2013;3:e002233.
  • 12. Muriuki JM, Mentzer AJ, Kimita W, Ndungu FM, Macharia AW, Webb EL, etal. Iron Status and Associated Malaria Risk Among African Children. Clin Infect Dis. 2018 Sep 14.
  • 13. André HP, Sperandio N, Siqueira RL, Franceschini SDCC, Priore SE. Food and nutrition insecurity indicators associated with iron deficiency anemia in Brazilian children: a systematic review. Cien Saude Colet. 2018;23(4):1159-67.
  • 14. Schneider JM, Fujii ML, Lamp CL, Lönnerdal B, Dewey KG, Zidenberg-Cherr S. The use of multiple logistic regression to identify risk factors associated with anemia and iron deficiency in a convenience sample of 12-36-mo-old children from low-income families. Am J Clin Nutr. 2008;87(3):614-20.
  • 15. Koc A, Kosecik M, Vural H, Erel O, Ataş A, Tatli MM. The frequency and etiology of anemia among children 6-16 years of age in the southeast region of Turkey. Turk J Pediatr. 2000;42(2):91–5.
  • 16. Cesur M, Temiz F, Acıpayam C, Kılınc M, AkkececiSeringec N. Disordered bone metabolism in hereditary spherocytosis patients. Hematology 2019;24(1):276-81.
  • 17. Weatherall DJ. The inherited diseases of hemoglobin are an emerging global health burden. Blood. 2010;115(22):4331-6.
  • 18. Taher AT, Weatherall DJ, Cappellini MD. Thalassaemia. Lancet. 2018;391(10116):155-67.

6ay-18 yaş arasındaki çocuklarda anemi etiyolojisi

Year 2019, , 402 - 405, 28.05.2019
https://doi.org/10.28982/josam.568900

Abstract

Amaç: Anemi, insan ve toplum sağlığını ilgilendiren önemli bir halk sağlığı sorunudur. Bu çalışmada farklı yaş gruplarında anemi etiyolojisini belirlemeyi ve sosyal farkındalık yaratmayı amaçladık.

Yöntemler: Çalışmaya (retrospektif kohort çalışması), Ocak 2015-Ocak 2018 tarihleri arasında, KSU Tıp Fakültesi Çocuk Hematoloji ve Onkoloji Polikliniğine başvuran 6 ay - 18 yaş arasındaki anemi hastaları dahil edilmiştir.

Bulgular: Çalışmaya 1120 hasta dahil edildi. 873 hastada Demir eksikliği anemisi, 184 hastada talasemi minör, 25 hastada vitamin B12 eksikliği anemisi, 13 hastada otoimmün hemolitik anemi, 10 hastada ise kalıtsal sferotositoz ve diğer anemi etiyolojileri vardı. Tüm hastaların% 16,4'ünde, 6-12 yaş arası hastaların % 33,8'inde talasemi minor vardı. Tüm hastaların %77,9’unda demir eksikliği anemisi vardı. 6 ay ile 2 yaş arası hastaların % 81,3'ünde, 2-6 yaş arası hastaların % 74,3'ünde, 6-12 yaş arası hastaların % 60,4'ünde ve 12-18 yaş arası hastaların % 85,0'inde demir eksikliği anemisi vardı. Demir eksikliği anemisi 2-6 yaş grubunda erkeklerde (%60,2) sık görülürken (P=0,002), 12-18 yaş grubunda kadınlarda (%80,6) yaygındı (P=0,000). 

Sonuç: Bu çalışmanın sonucunda risk altındaki toplumlarda tarama ve demir takviyesinin yapılması gerektiği sonucuna varılmıştır.

References

  • 1. Akca SO, Bostanci MÖ. The impact of anemia and body mass index (BMI) on neuromotor development of preschool children. Rev Assoc Med Bras. 2017;63(9):779-86.
  • 2. Janus J, Moerschel, SK. Evaluation of anemia in children. Am. Fam. Physician 2010;81(12):1462-71.
  • 3. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007;370:511-20.
  • 4. Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood. Am J Clin Nutr. 2006;84(6):1261-76.
  • 5. Lisboa MBMC, Oliveira EO, Lamounier JA, Silva CAM, Freitas RN. Prevalence of iron-deficiency anemia in children aged less than 60 months: A population-based study from the state of Minas Gerais, Brazil. Rev Nutr. 2015;28(2):121-31.
  • 6. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, etal. Global, regional, and national trends in hemoglobin concentration and prevalence of total and severe Anemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1:e16–25.
  • 7. Akkermans MD, Eussen SR, van der Horst-Graat JM, van Elburg RM, van Goudoever JB, Brus F. A micronutrient-fortified young-child formula improves the iron and vitamin D status of healthy young European children: a randomized, double-blind controlled trial. Am J Clin Nutr. 2017;105(2):391-9.
  • 8. Irwin JJ, Kirchner JT. Anemia in children. Am Fam Physician. 2001;64(8):1379-86.
  • 9. Zuffo CR, Osório MM, Taconeli CA, Schmidt ST, da Silva BH, Almeida CC. Prevalence and risk factors of anemia in children. J Pediatr (Rio J). 2016;92(4):353-60.
  • 10. Balcı YI, Karabulut A, Gürses D, Çövüt IE. Prevalence and risk factors of anemia among adolescents in Denizli, Turkey. Iran J Pediatr. 2012;22(1):77-81.
  • 11. Balarajan YS, Fawzi WW, Subramanian SV. Changing patterns of social inequalities in Anemia among women in India: crosssectional study using nationally representative data. BMJ Open. 2013;3:e002233.
  • 12. Muriuki JM, Mentzer AJ, Kimita W, Ndungu FM, Macharia AW, Webb EL, etal. Iron Status and Associated Malaria Risk Among African Children. Clin Infect Dis. 2018 Sep 14.
  • 13. André HP, Sperandio N, Siqueira RL, Franceschini SDCC, Priore SE. Food and nutrition insecurity indicators associated with iron deficiency anemia in Brazilian children: a systematic review. Cien Saude Colet. 2018;23(4):1159-67.
  • 14. Schneider JM, Fujii ML, Lamp CL, Lönnerdal B, Dewey KG, Zidenberg-Cherr S. The use of multiple logistic regression to identify risk factors associated with anemia and iron deficiency in a convenience sample of 12-36-mo-old children from low-income families. Am J Clin Nutr. 2008;87(3):614-20.
  • 15. Koc A, Kosecik M, Vural H, Erel O, Ataş A, Tatli MM. The frequency and etiology of anemia among children 6-16 years of age in the southeast region of Turkey. Turk J Pediatr. 2000;42(2):91–5.
  • 16. Cesur M, Temiz F, Acıpayam C, Kılınc M, AkkececiSeringec N. Disordered bone metabolism in hereditary spherocytosis patients. Hematology 2019;24(1):276-81.
  • 17. Weatherall DJ. The inherited diseases of hemoglobin are an emerging global health burden. Blood. 2010;115(22):4331-6.
  • 18. Taher AT, Weatherall DJ, Cappellini MD. Thalassaemia. Lancet. 2018;391(10116):155-67.
There are 18 citations in total.

Details

Primary Language English
Subjects Haematology
Journal Section Research article
Authors

Ömer Duyuran 0000-0003-3087-0587

Can Acıpayam 0000-0002-6379-224X

Nurten Seringeç Akkeçeci 0000-0003-1915-2330

Sevcan İpek 0000-0002-1406-4895

Rumeysa Duyuran 0000-0002-7110-0303

Publication Date May 28, 2019
Published in Issue Year 2019

Cite

APA Duyuran, Ö., Acıpayam, C., Seringeç Akkeçeci, N., İpek, S., et al. (2019). Etiology of anemia in children aged between 6 months and 18 years. Journal of Surgery and Medicine, 3(5), 402-405. https://doi.org/10.28982/josam.568900
AMA Duyuran Ö, Acıpayam C, Seringeç Akkeçeci N, İpek S, Duyuran R. Etiology of anemia in children aged between 6 months and 18 years. J Surg Med. May 2019;3(5):402-405. doi:10.28982/josam.568900
Chicago Duyuran, Ömer, Can Acıpayam, Nurten Seringeç Akkeçeci, Sevcan İpek, and Rumeysa Duyuran. “Etiology of Anemia in Children Aged Between 6 Months and 18 Years”. Journal of Surgery and Medicine 3, no. 5 (May 2019): 402-5. https://doi.org/10.28982/josam.568900.
EndNote Duyuran Ö, Acıpayam C, Seringeç Akkeçeci N, İpek S, Duyuran R (May 1, 2019) Etiology of anemia in children aged between 6 months and 18 years. Journal of Surgery and Medicine 3 5 402–405.
IEEE Ö. Duyuran, C. Acıpayam, N. Seringeç Akkeçeci, S. İpek, and R. Duyuran, “Etiology of anemia in children aged between 6 months and 18 years”, J Surg Med, vol. 3, no. 5, pp. 402–405, 2019, doi: 10.28982/josam.568900.
ISNAD Duyuran, Ömer et al. “Etiology of Anemia in Children Aged Between 6 Months and 18 Years”. Journal of Surgery and Medicine 3/5 (May 2019), 402-405. https://doi.org/10.28982/josam.568900.
JAMA Duyuran Ö, Acıpayam C, Seringeç Akkeçeci N, İpek S, Duyuran R. Etiology of anemia in children aged between 6 months and 18 years. J Surg Med. 2019;3:402–405.
MLA Duyuran, Ömer et al. “Etiology of Anemia in Children Aged Between 6 Months and 18 Years”. Journal of Surgery and Medicine, vol. 3, no. 5, 2019, pp. 402-5, doi:10.28982/josam.568900.
Vancouver Duyuran Ö, Acıpayam C, Seringeç Akkeçeci N, İpek S, Duyuran R. Etiology of anemia in children aged between 6 months and 18 years. J Surg Med. 2019;3(5):402-5.