Serum aşikar hipotiroidizmin adipöz dokuda etkileri ve serum betatrophin düzeyleri

Year 2019, , 631 - 634, 01.09.2019

Murat Akarsu , Şengül Aydın Yoldemir , Özgür Altun Okan Dikker , Mustafa Özcan Eylem Özgün Çil Semih Kalyon , İlkim Deniz Toprak Gazi Çapar Yücel Arman Tufan Tükek

https://doi.org/10.28982/josam.610414

Cited By: 1

Abstract

Amaç: Angiopoietin like peptit-8 olarak da bilinen betatrofin, adipöz doku ve karaciğerden sentezlenen glikoprotein yapısında bir adipokindir. Betatrofin, plazma lipoproteinlerinin hidrolizinde anahtar enzim olan lipoprotein lipaz’ı inhibe ederek yağ ve enerji metabolizmasında rol oynar. Tiroid hormonları enerji metabolizmasında aktif rol almasına rağmen kolesterol ve lipid metabolizmasıyla ilişkisi net değildir. Yaptığımız çalışmada hipotiroidi tanılı hastalarda serum betatrofin düzeylerinin enerji ve lipid metabolizması ile ilişkisini incelemeyi amaçladık.

Yöntemler: Bu bir vaka kontrol çalışmasıdır. Çalışmaya katılan hipotiroidi tanılı 44 hastanın (20 erkek, 24 kadın) yaş ortalaması 44,7 (13,8) idi. 19 Erkek ve 21 kadın olmak üzere toplam 40 sağlıklı gönüllü de kontrol grubu olarak çalışmaya katıldı. Sağlıklı gönüllülerin yaş ortalaması: 44,6 (14,4) yıl idi. Her iki grupta da açlık kan şekeri, AST, ALT, üre, kreatinin, TSH, serbest T3, serbest T4, HDL-kolesterol, LDL-kolesterol, trigliserit (TG), total kolesterol, anti-TPO, anti-TG, insülin, HOMA-IR düzeyleri ve ELISA yöntemiyle serum betatrofin düzeyleri ölçüldü. 

Bulgular: Kontrol grubuna kıyasla hipotiroidi tanısı konan hastalarda serum betatrofin düzeyleri anlamlı derecede yüksekti. (P=0,001). Serum betatrofin düzeyleri ile TSH, TG ve total kolesterol arasında pozitif yönde; HDL, serbest T3 ve serbest T4 ile negatif yönde korelasyon vardı. Hipotiroidili hasta grubunda anti-TPO yüksekliğine göre yapılan karşılaştırmada anlamlı farklılık yoktu (P=0,78).

Sonuç: Çalışmamızda hipotiroidi hastalarında serum betatrofin düzeylerinin yüksek olduğunu bulduk. Bu çalışma, klinik uygulamada betatrofeni hedef alan tedavilerin geliştirilmesinde faydalı olabilir.

Keywords

Hipotiroidizm, Betatrofin, Lipoprotein lipaz

The effects of overt hypothyroidism on adipose tissue and serum betatrophin levels

Abstract

Aim: Betatrophin, also known as angiopoietin-like peptide-8, is an adipokine in glycoprotein structure synthesized from adipose tissue and liver. Betatrophin plays a role in fat and energy metabolism by inhibiting lipoprotein lipase, the key enzyme in the hydrolysis of plasma lipoproteins. Although thyroid hormones have an active role in energy metabolism, their relationship with cholesterol and lipid metabolism is not clear. In our study, we aimed to investigate the relationship of serum betatrophin levels with energy and lipid metabolism in patients with overt hypothyroidism.

Methods: This is a case-control study. The mean age of 44 patients (20 males, 24 females) with hypothyroidism was 44.7 (13.8). A total of 40 healthy volunteers, including 19 males and 21 females, were included in the study as a control group. The mean age of healthy volunteers was 44.6 (14.4) years. Fasting blood glucose, AST, ALT, urea, creatinine, TSH, free T3, free T4, HDL-cholesterol, LDL-cholesterol, triglyceride (TG), total cholesterol, anti-TPO, anti-TG, insulin, HOMA-IR levels and serum betatrophin levels were measured by ELISA and compared in both groups.

Results: Serum betatrophin levels were significantly higher in patients diagnosed with hypothyroidism compared to the control group (P=0.001). Serum betatrophin levels were positively correlated with TSH, TG and total cholesterol, and negatively correlated with HDL, free T3 and free T4 levels. There was no significant difference in the comparison of patients regarding anti-TPO levels in the hypothyroidism group (P=0.78).

Conclusion: In our study, we found that serum betatrophin levels were high in hypothyroid patients. This study may be useful in the development of treatments targeting betatrophin in clinical practice.

Keywords

Hypothyroidism, Betatrophin, Lipoprotein lipase

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