Obstrüktif uyku apne sendromlu hastalarda eritrosit dağılım genişliği, ortalama trombosit hacmi ve trombosit dağılım aralığı karşılaştırılması

Abstract

Amaç: Obstrüktif uyku apne sendromunda (OUAS) intermitant hipoksiye bağlı gelişen kronik inflamasyonun PAP tedavisine yanıtını değerlendirmede kullanılacak güvenilir belirteçlere ihtiyaç vardır. Bu çalışmada, pozitif havayolu basıncı tedavisinin uzun dönem sonuçlarının hemogram parametreleri üzerine etkisini ve OUAS'lı hastalarda inflamasyon ve hastalığın ciddiyeti ile ilişkisini araştırmayı amaçladık.

Yöntemler: Çalışma prospektif kohort tipi çalışma olarak planlandı. Polisomnografi (PSG) sonuçlarına göre OUAS saptanmayan 61 katılımcı (%35.1) kontrol grubu olarak alındı. OUAS saptanan 113 hasta (%64,9) çalışma grubu olarak alındı. Çalışma grubunun (%31,6)’sı orta OUAS, 58'i (%33,3) şiddetli OUAS idi. Hastaların MPV, PDW, RDW, hemoglobin, hemotokrit, trombosit değerleri değerlendirildi ve altı ve on iki ay arayla karşılaştırıldı. 

Bulgular: Yaşları 33 ile 62 arasında değişen, toplam 174 hasta çalışmaya alındı. Başlangıçta hemoglobin, hematokrit ve MPV değerleri çalışma grubunda kontrol grubuna göre anlamlı derecede yüksek (sırasıyla P=0,008, P=0,007, P=0,004), her iki grupta da 6 ve 12 aydaki düşüşler istatistiksel olarak anlamlıydı (sırasıyla P=0,004, P=0,003, P=0,004).

Sonuç: Tüm katılımcıların erkek olması hemogram parametrelerine hormonal etkilerin dışlanması nedeni ile idi. Ancak çalışmaya sadece erkek katılımcıların dahil edilmesi aynı zamanda bu çalışmanın limitasyonu olabilir. Çalışmamız MPV, RDW, PDW ve hemoglobin, hematokrit değerleri ve OUAS şiddeti arasında bir ilişki olduğunu göstermiştir. MPV, RDW, hemoglobin, hematokrit, trombosit, PAP tedavisini değerlendirmeyi bekleyen OUAS hastalarını önceliklendirmede faydalı kılan basit, ucuz bir kan biyobelirteçine dönüşebilir.

Keywords

• Obstrüktif uyku apne sendromu,Eritrosit dağılım genişliği,Ortalama trombosit hacmi,Trombosit dağılım aralığı

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Abstract

Aim: Reliable markers are needed to evaluate the response of chronic inflammation in obstructive sleep apnea syndrome (OSAS) to positive airway pressure (PAP) treatment. In this study, we aimed to investigate the long-term effects of PAP treatment on hemogram parameters and its relationship with inflammation and severity of disease in OSAS patients.

Methods: Based on polysomnography (PSG) results, 61 (35.1%) participants and 113 OSAS patients (64.9%) were included in the control and study groups, respectively. Among these patients, 31.6% had moderate and 33.3% had severe OSAS. MPV, PDW, RDW, hemoglobin, hemotocrit, platelet values were evaluated and compared between the groups at six and twelve-month intervals in this prospective cohort study. 

Results: All participants (n=174) were males aged between 33-62 years. Hemoglobin, hematocrit and MPV values of the study group were significantly higher at the baseline (P=0.008, P=0.007, P=0.004, respectively) and had decreased significantly by the 6th and 12th months in both groups P=0.004, P=0.003, P=0.004, respectively). 

Conclusion: All participants were chosen from males to exclude hormonal effects on hemogram parameters, which also turned out to be a limitation of this study. Our study showed a correlation between MPV, RDW, PDW, hemoglobin and hematocrit values and OSAS severity. MPV, RDW, hemoglobin, hematocrit and platelet may be considered inexpensive biomarkers easily obtained from blood tests which make it useful in determining the severity of OSAS and prioritizing patients for PAP therapy.

Keywords

• Obstructive sleep apnea syndrome,Red cell distribution width,Mean platelet volume,Platelet distribution width

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