Çok nadir bir komplikasyon; Sildenafil kullanımı sonrasi gelişen spinal kord intramedüller kanaması (hematomiyeli)

Year 2019, , 782 - 784, 01.10.2019

İsmail Taşkent , Hanefi Yıldırım

https://doi.org/10.28982/josam.635056

Abstract

Sildenafil kullanımının çeşitli komplikasyonlarının yanında intrakranial kanamaya da neden olduğunu gösteren olgular bildirilmiş olmasına rağmen, sildenafil kullanımı sonrası spinal kord intramedüller kanaması (Hematomyelia) henüz bildirilmemiştir. Bu olguda, sildenafil kullandıktan sonra sol kola yayılan ağrı ve uyuşukluk şikayetleri ile nöroloji kliniğine başvuran 50 yaşında erkek hastadan bahsedildi. Görüntüleme yöntemlerinden sonra hematomiyeli tanısı aldı. Sildenafil kullanımı dışında hematomiyeliye neden olabilecek diğer patolojiler ekarte edildi.

Keywords

İntramedüller kanama, Hematomiyeli, Servikal kord, Sildenafil

Spinal cord intramedullary hemorrhage (hematomyelia) after use of sildenafil: A very rare complication

Abstract

Sildenafil’s complications include intracranial hemorrhage along with others, however, spinal cord intramedullary hemorrhage (Hematomyelia) after using sildenafil has not been previously reported. We herein present the case of a 50-year-old male patient who was referred to the Neurology department with pain and numbness radiating to the left arm after use of sildenafil. He was diagnosed with hematomyelia after various diagnostic tests. Other pathologies that might have caused hematomyelia were ruled out.

Keywords

Intramedullary hemorrhage, Hematomyelia, Cervical cord, Sildenafil

References

• 1. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol. 1998;159:2164–71.
• 2. Morales A, Gingell C, Collins M, Wicker PA, Osterloh IH. Clinical safety of oral sildenafil citrate (VIAGRA) in the treatment of erectile dysfunction. Int J Impot Res. 1998;10:69–73.
• 3. Morgan JC, Alhatou M, Oberlies J, Johnston KC. Transient ischemic attack and stroke associated with sildenafil (Viagra) use. Neurology. 2001;57:1730–1.
• 4. Alpsan MH, Bebek N, Ciftci FD, Coban O, Bahar S, Tuncay R. Intracerebral hemorrhage associated with sildenafil use: a case report. J Neurol. 2008;255:932–3.
• 5. Buxton N, Flannery T, Wild D, Bassi S. Sildenafil (Viagra)-induced spontaneous intracerebral haemorrhage. Br J Neurosurg. 2001;15:347–9.
• 6. Monastero R, Pipia C, Camarda LK, Camarda R. Intracerebral haemorrhage associated with sildenafil citrate. J Neurol. 2001;248:141–2.
• 7. Irazoque-Palazuelos F, Sosa-Espinosa PV, Andrade-Ortega L. Hematomyelia in systemic lupus erythematosus and secondary antiphospholipid syndrome: case report. Reumatol Clin. 2008;4:34-6.
• 8. Richardson JC. Spontaneous hematomyelia: a short review and a case report illustrating intramedullary angioma and syphilis of the spinal cord as possible causes. Brain. 1938;61:17-36.
• 9. Pobiel RS, Schellhas KP, Eklund JA, Golden MJ, Johnson BA, Chopra S, et al. Selective cervical nerve root blockade: prospective study of immediate and longer term complications.AJNR Am J Neuroradiol. 2009;30(3):507-11.
• 10. Miyakoshi N, Hongo M, Kasukawa Y, Ando S, Shimada Y. Thoracic disk herniation with hematoma-case report. Neurol Med Chir (Tokyo). 2008; 48(9):414-7.
• 11. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cadiol. 1999;83:35–44.
• 12. Berkels R, Klotz T, Sticht G, Englemann U, Klaus W. Modulation of human platelet aggregation by the phosphodiesterase type 5 inhibitor sildenafil. J Cardiovasc Pharmacol. 2001;37:413–21.
• 13. Leep Hunderfund AN, Wijdicks EF. Intramedullary spinal cord hemorrhage (hematomyelia) Rev Neurol Dis. 2009;6:E54–61.
• 14. Heldner MR, Arnold M, Nedeltchev K, Gralla J, Beck J, Fischer U. Vascular diseases of the spinal cord: a review. Curr Treat Options Neurol. 2012;14:509–20. doi: 10.1007/s11940-012-0190-9.