Esansiyel tremoru ve Parkinson hastalığı olan hastalarda retina sinir lifi tabaka kalınlığı

Year 2019, , 865 - 869, 03.12.2019

Halit Fidancı , Nevra Öksüz , Şeyda Özal , Ufuk Adıgüzel , Şükrü Kaleağası , Okan Doğu

https://doi.org/10.28982/josam.661757

Abstract

Amaç: Esansiyel tremor (ET) ve Parkinson hastalığı (PH) yaygın hareket bozukluklarındandır. PH’de renkli görmede bozulma ve görme keskinliğinde azalma gibi görme sorunları bildirilmiştir. Çalışmalar, optik koherens tomografi (OKT) ile ölçülebilen retina sinir lifi tabaka (RSLT) kalınlığının PH ve bazı nörodejeneratif hastalıklarda azaldığını göstermiştir. ET ve PH hastalığının benzer özellikleri olması nedeniyle, ET ve PH hastalarında OKT kullanarak RSLT'yi değerlendirmeyi amaçladık.

Yöntemler: Bu prospektif vaka-kontrol çalışmasında PH, ET ve kontrol grupları oluşturuldu. Her grupta 30 kişi mevcuttu ve 180 göz incelendi. Bu gruplarda, RSLT kadranları, makula ve fovea OKT ile değerlendirildi. ET grubunda titreme şiddeti analizlere dahil edildi. PH'de hastalığın şiddeti Birleşik Parkinson Hastalığı Değerlendirme Ölçeği ve Hoehn ve Yahr ölçeği ile değerlendirildi.

Bulgular: Kontrol, ET ve PH gruplarında sağ gözün ortalama RSLT kalınlığı sırasıyla 93,2 (8,1), 86,7 (9,7), 86,8 (10,2) μm idi. PH ve ET gruplarında bu değerler kontrol grubuna göre daha düşüktü (P=0,026, P=0,025). ET'de hastalık şiddeti ile RSLT kalınlığı arasında ilişki bulunmadı.

Sonuç: ET'de azalmış RSLT kalınlığı, ET'nin PH gibi bir nörodejeneratif hastalık olduğunu gösterebilir. ET'de subklinik retinal bir etkilenme olabilir.

Keywords

Esansiyel tremor, Optik koherens tomografi, Parkinson hastalığı, Retinal sinir lifi tabakası

Project Number

BAP-TFDTB(HF)2014-1TU

Retinal nerve fiber layer thickness in patients with essential tremor and Parkinson’s disease

Abstract

Aim: Essential tremor (ET) and Parkinson’s disease (PD) are common movement disorders. In PD, visual problems such as impaired color vision and decreased visual acuity have been reported. Studies have shown that retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) is decreased in PD and some neurodegenerative diseases. Due to the similarities of ET and PD, we aimed to evaluate RNFL measured by OCT in ET and PD patients. 

Methods: PD, ET and control groups were formed in this prospective case-control study. Each group included 30 individuals, and 180 eyes were examined. In these groups, RNFL quadrants, macula and fovea were evaluated with OCT. In the ET group, tremor severity was included in the analyses. The severity of disease in PD was assessed with the Unified Parkinson's Disease Rating scale and the Hoehn and Yahr scale. 

Results: In the control, ET and PD groups, the mean RNFL thicknesses of the right eye were 93.2 (8.1), 86.7 (9.7), 86.8 (10.2) μm, respectively. These values were lower in the PD and ET groups compared to the control group (P=0.026, P=0.025). There was no correlation between disease severity and RNFL thickness in ET. 

Conclusion: Decreased RNFL thickness in ET may indicate that ET is a neurodegenerative disease, such as PD. There may be subclinical retinal impairment in ET.

Keywords

Parkinson’s disease, Essential tremor, Optical coherence tomography, Retinal nerve fiber layer

Supporting Institution

The scientific research projects fund of Mersin University

Project Number

BAP-TFDTB(HF)2014-1TU

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