Annelerdeki vitamin B12 ve folat düzeylerinin, yenidoğanlardaki vitamin B12 ve folat düzeyleri, antropometrik ölçümler ve metabolik belirteçlerle ilişkisi

Year 2020, , 43 - 47, 02.01.2020

Emel Ünsür , Burçin Kınaş , Fatma Kutlusoy Ülkü Aksoy Kıvanç Şahin Tolga Ünsür Huseyin Aksoy Nilgün Tekkeşin

https://doi.org/10.28982/josam.669066

Cited By: 1

Abstract

Amaç: Gebelikteki besin dengesizlikleri yenidoğanın gelecek yaşamında obeziteye neden olan metabolik problemlere yol açabilir. Çalışmamızda, gebeliğin sonunda annelerdeki folik asit, B12 vitamini düzeylerini belirlemek, yenidoğanın antropometrik ölçümleri, serum lipit profili, insülin direnci gibi metabolik göstergeleri arasındaki ilişkiyi araştırmak amaçlandı.

Yöntemler: Toplam 102 anne ve bebek prospektif kohort çalışmaya dahil edildi. Demografik, obstetrik özellikler, serum B12 vitamini, folat, glikoz, yüksek yoğunluklu lipoprotein (HDL), düşük yoğunluklu lipoprotein (LDL), trigliseritler, kolesterol, insülin, homosistein ve homeostatik model değerlendirmesi (HOMA-IR ) not edildi. B12 vitamini için, ≥191 ng/L seviyeleri normal olarak kabul edildi. Maternal vitamin B12 ve folat seviyeleri ile yenidoğanların metabolik göstergeleri, antropometrik ölçümleri arasındaki ilişki araştırıldı.

Bulgular: Serum vitamin B12 düzeyi düşük olan annelerden doğan bebeklerde vücut kitle indeksi (P=0,004), serum insülin düzeyleri (P=0,012), HOMA-IR (P=0,001) ve homosistein (P=0,001) düzeyleri artmış olarak saptandı. Maternal B12 vitamini düzeylerinin, yenidoğan B12 vitamini düzeyleri ile kuvvetli korelasyon (r=0,719, P<0,001); serum insülin (r=-0,221, P=0,025), HOMA-IR (r=-0,249, P=0,011), homosistein (r=-0,394, P<0,001) seviyeleri arasında ters zayıf bir korelasyon saptandı. Maternal folat düzeyleri neonatal folat düzeyleri ile kuvvetli pozitif (r=0,735, P<0,001); yenidoğan B12 vitamini düzeyleri ile zayıf pozitif (r=0,327, P=0,001); neonatal homosistein seviyeleri ile orta derecede ters korelasyon gösterdi (r=-0,505, P<0,001).

Sonuç: Gebelik döneminde annelerde vitamin değerlerinin optimal seviyelerde tutulması, bebeklerin gelecek yaşamlarında obeziteye yol açabilecek metabolik dengesizliklerini azaltmak açısından önemlidir.

Keywords

Gebelik, Vitamin B12, Folat, Yenidoğan, İnsülin direnci, Metabolik belirteçler

Supporting Institution

-

Thanks

DR FATMA KUTLUSOY,DR KIVANÇ ŞAHİN,DR ÜLKÜ AKSOY

The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators

Abstract

Aim: The nutritional imbalances in pregnancy may lead to metabolic problems in newborns, which may cause obesity during childhood and later in life. It is aimed to determine the maternal levels of folate, vitamin B12 at birth and to investigate the correlation between neonatal anthropometric measurements, and metabolic indicators such as serum lipid profile and insulin resistance.

Methods: A total of 102 mothers and newborns were enrolled in this prospective cohort study. The demographic, obstetric features, serum levels of vitamin B12, folate, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, cholesterol, insulin, homocysteine, and homeostatic model assessment (HOMA-IR) were noted. For vitamin B12, levels, ≥191 ng/L were accepted as normal. The correlation between maternal levels of vitamin B12, folate, anthropometric measurements, and metabolic indicators of newborns were evaluated. 

Results: Body mass index (P=0.004), serum insulin levels (P=0.012), HOMA-IR (P=0.001), and homocysteine (P=0.001) were increased in neonates born from mothers with lower serum levels of vitamin B12. The maternal vitamin B12 levels were positively, strongly correlated with neonatal vitamin B12 levels (r=0.719, P<0.001). There was an inverse, weak correlation between maternal vitamin B12 levels and neonatal serum insulin levels (r=-0.221, P=0.025), HOMA-IR (r=-0.249, P=0.011), and homocysteine (r=-0.394, P<0.001). Maternal folate levels were strongly, positively correlated with neonatal folate (r=0.735, P<0.001); weakly, positively correlated with neonatal vitamin B12 (r=0.327, P=0.001); moderately, inversely correlated with neonatal homocysteine (r=-0.505, P<0.001).

Conclusion: Optimizing intake of these vitamins levels during pregnancy is important to reduce the neonatal metabolic abnormalities, which may lead to obesity later in life.

Keywords

Pregnancy, Vitamin B12, Folate, Neonates, Insulin resistance, Metabolic indicators

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