Infantile juvenile polyposis syndrome: A rare cause of protein-losing enteropathy

Abstract

Juvenile Polyposis Syndrome (JPS) is a rare autosomal dominant hereditary syndrome affecting 1:100000-160000 individuals. JPS most presents with rectal bleeding, anemia, abdominal pain, obstruction and rarely with rectal prolapsus of the polyp. In this case, we diagnosed Infantile Juvenile Polyposis Syndrome due to protein losing enteropathy, rectal bleeding and extraintestinal manifestations of the syndrome. A 2-year-old male infant was referred to the hospital due to complaints of painless rectal bleeding and rectal prolapsus of the polyp which occurred at 15 months of age. Pathological examination revealed that it was a juvenile polyp. After a short while, the patient was hospitalized due to rectal bleeding, paleness, swelling in both legs and periorbital edema. Physical examination of the patient revealed +3 pretibial, scrotal, periorbital edema, clubbing and pale appearance. The patient had macrocephaly, hypotonicity and neuromotor retardation. Laboratory test results revealed low immunoglobulin levels, hypoalbuminemia, anemia, and electrolyte imbalance. We diagnosed the case with JPS due to protein losing enteropathy with extraintestinal manifestations of the syndrome. Gastroscopic and colonoscopic examinations revealed multiple polyps through the antrum and colon. JPS diagnosis is based on the detection of polyps which are histopathologically defined as juvenile polyps. One of the most common causes of painless, rectal bleeding in children are colorectal polyps. We wanted to emphasize that the sporadic juvenile polyp diagnosis should be made by pathological examination of polypectomy material and clinical exclusion of JPS. In our patient, there were extraintestinal system manifestations such as macrocephaly, congenital heart disease and clubbing, accompanied with protein-losing enteropathy. Awareness of these clinical findings is necessary for the differential diagnosis of protein-losing enteropathy and polyposis syndrome. We would also like to draw attention to the importance of a multidisciplinary approach, early recognition of the syndrome and appropriate referral of the patient.

Keywords

• rectal bleeding
• Infantile Juvenile Polyposis Syndrome
• Protein Lossing Enteropaty

İnfantil juvenil poliposis sendromu: Protein kaybettiren enteropatinin nadir bir nedeni

Abstract

Juvenil Polipozis Sendromu (JPS), çok nadir görülen, otozomal dominant geçişli, 1/100000 ile 1/160000 insanı etkileyen, herediter bir sendromdur. JPS sıklıkla rektal kanama, anemi, karın ağrısı, tıkanma ve nadiren polipin rektal prolapsusu ile bulgu verir. Bu olgu ile protein kaybettiren enteropati, rektal kanama ve ekstraintestinal manifestasyonları olan hastamıza JPS tanısı koyduk. 2 yaş erkek hasta ağrısız rektal kanama nedeniyle hastaneye başvurdu. 15 aylık iken rektal polip prolapsusu olmuş ve bu polipin patolojik değerlendirmesi juvenil polip ile uyumlu imiş. Çok kısa süre sonra hasta rektal kanama, solukluk, ayaklarda şişlik ve göz çevresi ödem ile başvurdu. Fizik muayenesinde pretibial +3 ödem, skrotal ödem, göz çevresinde ödem, parmaklarda çomaklaşma ve soluk görünümü mevcut idi. Makrosefali, hipotoni ve nöromotor retardasyonu vardı. Laboratuvar testlerinde: immunglobulinler ve albumin düşük, anemisi mevcut ve elektrolit dengesizliği vardı. JPS tanısı protein kaybettiren enteropatiye eşlik eden ekstraintestinal system bulgularının varlığı ile konuldu. Yapılan gastroskopik ve kolonoskopik incelemesinde antrumdan başlayarak tüm kolon mukozası boyunca yaygın polipler mevcut idi. Histopatolojik incelemesi juvenil polip ile uyumlu idi. Çocuklarda ağrısız rektal kanamaların en sık nedeni kolorektal poliplerdir. Sporadik juvenil polip tanısı, patolojik olarak polipektomi materyalinin incelenmesi ve klinik olarak JPS’nun dışlanması ile konulmalıdır, bunu vurgulamak istedik. Bizim hastamızdaki gibi makrosefali, konjenital kalp hastalığı ve çomak parmak gibi ekstraintestinal bulguların farkındalığı ve protein kaybettiren enteropati ayırıcı tanısında polipozis sendromunun akılda tutulması gerektiğini vurgulamak istedik. Multidisipliner yaklaşım ile erken tanı prognozu iyileştirebilmektedir.

Keywords

• Rektal kanama
• İnfantil juvenil polipozis sendromu
• Protein kaybettiren enteropati

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