Relationship between cardiovascular risk factors and coronary artery disease severity assessed by coronary angiography in Turkish patients

Abstract

Aim: Established coronary risk factors are good predictors of the occurrence of coronary artery disease (CAD), but their correlation with angiographic seriousness of the disease is argumentative and may vary among ethnic groups. In this study, we examined which of these factors are associated with the angiographic seriousness in Turkish patients with attested CAD. Methods: A total of 2433 patients who underwent coronary angiography and were diagnosed with critical lesions in at least one coronary artery were included in the study. Coronary risk factors were determined by retrospectively scanning the patient records and the relationship with the angiographic severity of coronary artery disease was investigated. Results: Most patients (36.4%) were between 60-69 years of age and approximately two thirds of patients (76.8%) were men. Hypertension, diabetes mellitus and hyperlipidemia were common cardiovascular risk factors (CRFs), present in 54.8%, 43.2% and 50.3% of patients, respectively. Multiple logistic regression analysis showed that diabetes mellitus, male sex and age since 6th decade significantly raised the risk of multivessel CAD (Odds ratios: 1.29 (1.08-1.54; P=0.004), 1.35 (1.1-1.66; P=0.004), 3.53 (1.85-6.75; P<0.001), respectively). Hypertension and hyperlipidemia were not correlated with CAD angiographic severity. Conclusion: Diabetes mellitus appeared as the modifiable coronary risk factor forecasting multivessel coronary artery disease in Turkish patients.

Keywords

• Turkish
• ethnic
• angiography
• risk
• multi vesseL

Koroner anjiyografi ile değerlendirilmiş Türk hastalarda kardiyovasküler risk faktörleri ve koroner arter hastalığı ciddiyeti arasındaki ilişki

Öz

Amaç: Koroner arter hastalığı risk faktörleri, koroner arter hastalığının (KAH) ortaya çıkışının iyi öngördürücülerdir, ancak bunların hastalığın anjiyografik ciddiyeti ile korelasyonları tartışmalıdır ve etnik gruplar arasında farklılık gösterebilir. Bu çalışmada, kanıtlanmış KAH olan Türk hastalarda kardiyovasküler risk faktörlerinin hastalığın anjiyografik ciddiyeti ile ilişkisi araştırıldı. Yöntemler: Koroner anjiyografi ile değerlendirilerek en az bir koroner arterde kritik lezyon saptanan 2433 hasta çalışmaya dahil edildi. Hasta kayıtları retrospektif taranarak hastaların koroner risk faktörleri tespit edildi ve koroner arter hastalığının anjiyografik ciddiyeti ile ilişkisi araştıırldı. Bulgular: Çalışma popülasyonunda hastaların çoğu (%36,4) 60-69 yaşları arasındaydı ve hastaların yaklaşık üçte ikisi (%76,8) erkekti. Hipertansiyon, diyabetes mellitus ve hiperlipidemi hastaların sırasıyla% 54,8,%43,2 ve %50,3'ünde mevcuttu. Çoklu lojistik regresyon analizinde, diabetes mellitus, erkek cinsiyet ve 6. dekattan itibaren yaşın, çok damarlı KAH riskini önemli ölçüde artırdığı saptandı (odds oranları sırasıyla 1,29 (1,08-1,54; P=0,004), 1,35 (1,1-1,66; P=0,004), 3,53 (1,85-6,75; P<0,001). Hipertansiyon ve hiperlipidemi, KAH’ın anjiyografik ciddiyeti ile ilişkili değildi. Sonuç: Türk hastalarda çok-damar koroner arter hastalığını ön gördüren düzeltilebilir koroner arter hastalığı risk faktörü diyabetes mellitustur.

Anahtar Kelimeler

• Türk
• Etnik
• Anjiyografi
• Risk
• Çoklu damar

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