Association of Borna disease virus with autism spectrum disorder in Turkish children

Year 2020, , 986 - 989, 01.11.2020

Arzu Altunçekiç Yıldırım , Yeliz Çetinkol , Erman Esnafoglu , Mustafa Kerem Çalgın

https://doi.org/10.28982/josam.748864

Cited By: 1

Abstract

Aim: Autism spectrum disorders are lifelong neurodevelopmental disorders whose pathogeneses are not fully understood. Borna disease virus is a neurotropic virus that affects the central nervous system. Considering the neuropsychiatric and behavioral effects of the virus, it can be suggested that it may play a role in autism spectrum disorder. However, there are insufficient evidence to support this. In this study, we aimed to investigate the presence of Borna disease virus in patients with autism spectrum disorders and healthy controls.
Methods: This case-control study, performed in children with autism spectrum disorders and a control group, included patients with autism who visited the Child and Adolescent Psychiatry outpatient clinic between December 2017 - December 2018. Borna virus positivity was assayed with the ELISA method in serum samples. Data was analyzed using SPSS version 22.
Results: The study included 63 children diagnosed with autism spectrum disorder and 31 healthy controls. The age range of autism patients was 3-14 years, their mean age was 7.83 (1.96) years, and The Childhood Autism Rating Scale score was 51.09 (5.71). The seropositivity rate for Borna disease virus in the autism and healthy control groups were 25.39% and 25.80%, respectively (P=0.966). For all patients, seropositivity rate was 25.53%.
Conclusion: No relationship was found between autism spectrum disorders and Borna disease virus. The clinical significance of Borna disease virus positivity in society is unknown. We conclude that Borna disease virus is not involved in the pathogenesis of autism spectrum disorders.

Keywords

Borna disease virus, autism spectrum disorder, seroprevalence, etiology

Supporting Institution

Ordu University Scientific Research Project Fund.

Project Number

AP-1725

Türk çocuklarda Borna hastalığı virüsü ve otizm spektrum bozukluğu ilişkisi

Abstract

Amaç: Otizm spektrum bozuklukları yaşam boyu nörogelişimsel bozukluklardır ve patogenezi günümüzde tam olarak anlaşılamamıştır. Borna hastalığı virüsü, merkezi sinir sistemini etkileyen nörotropik bir virüstür. Virüsün nöropsikiyatrik ve davranışsal etkileri göz önüne alındığında, otizm spektrum bozukluğunda rol oynayabileceği ileri sürülebilir. Ancak, bunu destekleyecek yeterli kanıt yoktur. Bu çalışmada otizm spektrum bozukluğuna sahip hastalarda ve sağlıklı kontrol grubunda Borna hastalığı virüsü varlığının araştırılması amaçlanmıştır.
Yöntemler: Bu çalışma otizm spektrum bozukluğu tanısı almış ve kontrol grubundaki çocuklarda yapılan bir vaka kontrol çalışmasıdır. Çalışmaya Aralık 2017 - Aralık 2018 tarihleri arasında Çocuk ve Ergen Psikiyatri polikliniğine başvuran otizmli çocuklar dahil edilmiştir. Serum örneklerinde ELISA yöntemi ile Borna virüsü pozitifliği değerlendirilmiştir. Veriler SPSS sürüm 22 kullanılarak analiz edilmiştir.
Bulgular: Çalışmaya otizm spektrum bozukluğu tanısı almış 63 çocuk ve 31 sağlıklı kontrol grubu dahil edildi. Otizm hastalarının yaş aralığı 3-14 yıl, ortalama yaş 7,83 (1,96) ve Çocukluk Otizmini Derecelendirme Ölçeği skoru ortalama 51,09 (5,71) olarak saptandı. Otizm grubunda ve sağlıklı kontrol grubunda Borna hastalığı virüsü seropozitiflik oranı sırasıyla %25,39 ve %25,80 idi (P=0,966). Tüm hastalar için seropozitiflik oranı %25,53 saptandı.
Sonuç: Otizm spektrum bozukluğu ile Borna hastalığı virüsü arasında ilişki saptanmadı. Borna hastalığı virüsünün toplumdaki pozitifliğinin klinik önemi bilinmemektedir. Sonuç olarak Borna hastalığı virüsünün, otizm spektrum bozukluğunun patogenezinde rol oynadığını düşünmüyoruz.

Keywords

Borna hastalığı virüsü, otizm spektrum bozukluğu, seroprevalans, etyoloji

Project Number

AP-1725

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