Polikistikover sendromlu hastalarda visseral adiposite indeksi ve lipid birikim ürünlerinin metabolik, antropometrik ve hormonal parametrelerle ilişkisi

Year 2020, , 664 - 668, 01.08.2020

Gültekin Adanas , Gülten Özgen

https://doi.org/10.28982/josam.755729

Abstract

Amaç: Polikistik over sendromu (PKOS) üreme çağında en sık görülen endokrinopati olup santral obezite, glukoz intoleransı, dislipidemi ve hipertansiyon ile ilişkilidir. Visseral adipozite indeksi (VAI) ve lipid birikim ürünleri (LAP) insülin duyarlılığı dışında kardiyovasküler ve serebrovasküler olaylar ile de ilişkili olduğu saptanmıştır. Bizler de, bu çalışmamızda PKOS ve kontrol grubu hastalarımızda VAI ve LAP ile metabolik, antropometrik ve hormonal parametreler arasındaki ilişkileri değerlendirdik.
Yöntemler: Çalışmaya 18-35 yaş aralığında 106’sı Rotterdam kriterlerine göre PKOS grubunda olmak üzere toplam 172 hasta dahil edildi. Diabetes mellitus, Cushing sendromu, hiperprolaktinemi, konjenital adrenal hiperplazi, hipertansiyon ve tiroid bozukluğu olan hastalar çalışmaya dahil edilmedi. LAP ve VAI indekslerinin hesaplanması için HDL ve trigliserid düzeylerine bakıldı.
Bulgular: PKOS’lu hasta grubunda LAP ile HDL-C (r=-0,644) arasında anlamlı negatif korelasyon saptanırken, trigliserid (r=0,706) ve kalça çevresi (r=0,872) arasında pozitif korelasyon saptandı. Yine VAI ile bel çevresi (r=0,625) ve HOMA-IR (r=0,462) arasında pozitif korelasyon saptandı.
Sonuç: Bu çalışmada PKOS hasta grubunda VAI’nın insülin direncini belirlemede yararlı bir indeks olduğu sonucuna varıldı.

Keywords

Polikistik over sendromu, Visseral adipozite indeksi, Lipid birikim ürünleri

The relation of visceral adiposity index and lipid accumulation product with metabolic, anthropometric, and hormonal parameters in patients with polycystic ovary syndrome

Abstract

Aim: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and is associated with glucose intolerance, central obesity, hypertension, and dyslipidemia. The Visceral Adiposity Index (VAI) and Lipid Accumulation Product (LAP) are effective indices for predicting insulin resistance are associated with cardiovascular and cerebrovascular events. In this study, we aimed to investigate the relationship of VAI and LAP with metabolic, anthropometric, and hormonal parameters in PCOS patients.
Methods: A total of 106 patients with PCOS who were diagnosed according to the Rotterdam criteria and 66 healthy controls without PCOS aged 18-35 years were included in this prospective, case-control study. Patients with diabetes mellitus, Cushing syndrome, hyperprolactinemia, congenital adrenal hyperplasia, hypertension, or thyroid disorder were excluded. The VAI and LAP were calculated based on the high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels.
Results: There was a negative, significant correlation between LAP and HDL-C (r=-0.644), a positive, significant correlation between TG (r=0.706) and hip circumference (r=0.872), and a positive, significant correlation between VAI and waist circumference (r=0.625) in the PCOS group. There was also a positive, significant correlation between HOMA-IR and VAI in the PCOS group (r=0.462).
Conclusion: Our study results suggest that VAI seems to be a more useful index for predicting insulin resistance in PCOS patients.

Keywords

Lipid accumulation product, polycystic ovary syndrome, Visceral adiposity index

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