Mezenkimal kök hücreler testis hasarını iyileştirebilir mi? Güncel çalışmalar

Öz

Son zamanlarda yapılan birçok çalışma, farklı hastalık modellerinde mezenkimal kök hücrelerin (MKH) terapötik etkilerini göstermiştir. İnfertilite, yüksek prevalansa sahip global bir hastalıktır. Obstrüktif olmayan azospermi, genetik faktörler, toksik maddelere maruz kalma, radyoterapi, kemoterapi gibi antikanser tedavileri ve testis torsiyonu nedeniyle ortaya çıkabilir. MKH'lerin farklılaşma kapasiteleri ve parakrin etkileri nedeniyle erkek infertilitesinin tedavisinde etkinliğini belirlemek için birçok çalışma yapılmıştır. Araştırmalarda, farklı kaynaklardan elde edilen MKH'lerin erkek germ hücrelerine farklılaşma kapasiteleri in vitro olarak belirlenmesinin yanı sıra bu hücrelerin testis nişi üzerindeki etkileri MKH'lerin testis içine enjekte edilmesiyle belirlenmiştir. Bu derlemede, obstrüktif olmayan azosperminin nedenlerinden birkaçına değindik ve MKH'lerin testis yaralanması üzerindeki terapötik etkilerini belirlemek için mevcut çalışmaları özetledik.

Anahtar Kelimeler

• Azospermi
• Erkek infertilitesi
• Mezenkimal kök hücreler
• Kök hücre tedavisi
• Testis hasarı

Can mesenchymal stem cells ameliorate testicular damage? Current researches

Abstract

Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. Infertility is a global disease with a high prevalence. Non-obstructive azoospermia may occur due to genetic factors, exposure to toxic substances, anticancer treatments such as radiotherapy and chemotherapy and testicular torsion. Many experiments have been conducted to determine the efficacy of MSCs in the treatment of male infertility due to their differentiation capacity and paracrine effect. In these studies, the differentiation capacities of MSCs, obtained from diverse sources, to male germ cells were determined in vitro and their effects on testis niche were assessed by injection of MSCs into the testis. In this review, we addressed a few of the causes of non-obstructive azoospermia and summarized the current studies to determine the therapeutic effects of MSCs on testicular injury.

Keywords

• Azoospermia
• Male infertility
• Mesenchymal stem cells
• Stem cell therapy
• Testicular damage

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