Kounis syndrome as a result of anaphylactic reaction to diclofenac sodium: A case report

Year 2018, Volume: 2 Issue: 3, 337 - 338, 01.09.2018

Abdullah İbrahim , Şahin Çolak , Mehmet Özgür Erdoğan , Mustafa Ahmet Afacan , Ayhan Sarıtaş , Hayati Kandiş

https://doi.org/10.28982/josam.402775

Abstract

Kounis syndrome refers to acute coronary syndromes of varying degrees (myocardial ischaemia to infarction) induced by mast cell activation as a result of allergic and anaphylactic reactions. Following subclinical, acute or chronic allergic reactions, it has a clinical spectrum ranging from chest pain to ST segment elevated myocardial infarction. The trigger of the allergic reaction can be drugs, food, environmental factors (insect bite, bee sting, pollen, latex contact). We present a case of a patient who developed Kounis syndrome as a result of anaphylactic reaction to Voltaren (Diclofenac sodium) which is one of the drugs widely used in the emergency departments as intramuscular pain killer. 

Keywords

Kounis syndrome, Diclofenac sodium, Hypersensitivity, Anaphylaxis

Diklofenak sodyum kullanımı sonrası anafilaktik reaksiyon sonucu gelişen Kounis sendromu: Olgu sunumu

Abstract

Kounis sendromu mast hücrelerinin etkinleşmesi ile seyreden alerji, hipersensitivite, anaflaksi veya anaflaktoid reaksiyonlarla ilişkili olarak akut koroner sendromun değişik derecelerini ifade eder. Subklinik olarak akut veya kronik alerjik reaksiyona eşlik eden ve göğüs ağrısından başlayıp ST elavasyonlu miyokard enfarktüsü kadar uzanan bir klinik spektruma sahiptir. İlaçlar, yiyecekler, çevresel etkenler (böcek ısırması, arı sokması, polenler, lateks teması gibi) alerjik reaksiyonu tetikleyen neden olabilir. Burada, acil servislerde yaygın olarak kullanılan Voltaren’e (Diklofenak sodyum) bağlı gelişen anafilaktik reaksiyonu olan bir Kounis sendrom vakasını sunuyoruz.

Keywords

Kounis sendromu, Diklofenak sodyum, Aşırı duyarlılık, Anafilaksi

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