Jejunum ve sigmoidal adenokarsinomun gastrointestinal stromal tümörlerinin senkron ilişkisi: Olgu sunumu

Year 2019, Volume: 3 Issue: 2, 191 - 193, 25.02.2019

Houssam Belghali , Anas Belhaj , Karim Ibn Majdoub İmane Taughrai Khalid Mazaz

https://doi.org/10.28982/josam.453908

Abstract

Sindirim kanalının epitelyal tümörü ile gastrointestinal stromal tümörün (GIST) birlikteliği çok nadirdir ve sindirim karsinomunun cerrahi tedavisi sırasında sıklıkla tesadüfen keşfedilmiştir. Mezenşimden gelişen bu tümörlerin, düşük malignite potansiyelleri göz önüne alındığında iyi bir prognoza sahip oldukları bilinmektedir. Bir genetik mutasyonun veya farklı histotiplerin tümörlerini indükleyebilen onkojenik bir maddenin olasılığı daha az akla yatkın görünmektedir, ancak yadsınamaz. Biz histolojisi bir GIST tanısı doğrulayan ince bağırsak tümörünün tesadüfen keşfiyle, sigmoid adenokarsinom için ameliyat edilen 74 yaşında bir hastayı sunuyoruz.

Keywords

Senkron tümörler, Gastrointestinal stromal tümör, Adenokarsinom, Sindirim sistemi

Synchronous association of gastrointestinal stromal tumors of the jejunum and sigmoidal adenocarcinoma: A case report

Abstract

The association of a
gastrointestinal stromal tumor (GIST) with an epithelial tumor of the digestive
tract is very rare and frequently discovered by chance during the surgical
treatment of digestive carcinoma. These tumors developed from the mesenchyme are
known to have a good prognosis given their low malignancy potential. The
possibility of a genetic mutation or an oncogenic agent capable of inducing
tumors of different histotypes seems less plausible but it is not to be
discarded. We report the case of a 74-year-old patient, operated for a sigmoid
adenocarcinoma, with incidental discovery of a small bowel tumor whose
histology confirmed the diagnosis of a GIST.

Keywords

Synchronous tumors, Gastrointestinal stromal tumor, Adenocarcinoma, Digestive tract

References

• 1. M’sakni I, Rammeh S, Chelbi E, et al. Adénocarcinome et tumeur stromale digestifs : association fortuite ou mécanisme oncogène commun : propos de deux observations. Ann Chir. 2006;131:464–7.
• 2. Miettinen M, Lasota J. Gastrointestinal stromal tumors pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23:70–83.
• 3. Maiorana A, Fante R, Maria Cesinaro A, Adriana Fano R. Synchronous occurrence of epithelial and stromal tumors in the stomach: a report of a 6 cases. Arch Pathol Lab Med. 2000;124:682–6.
• 4. Kaffes A, Hughes L, Hollinshead J, Katelaris P. Synchronous primary adenocarcinoma, mucosa-associated lymphoid tis- sue lymphoma and a stromal tumor in a Helicobacter pylori infected stomach. J Gastroenterol Hepatol. 2002;17:1033–6.
• 5. Agaimy A, Wunsch PH, Sobin LH, et al. Occurrence of other malignancies in patients with gastrointestinal stromal tumors. Semin Diagn Pathol. 2006;23:120–9. 

• 6. Wronski M, Ziarkiewicz-Wroblewska B, et al. Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms. World J Gastroenterol. 2006;12:5360–62.
• 7. Pandurengan RK, Dumont AG, Araujo DM, et al. Survival of patients with multiple primary malignancies: a study of 783 patients with gastrointestinal stromal tumor. Ann Oncol. 2010;21:2107–11.
• 8. Melis M, Choi EA, Anders R, et al. Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST). Int J Colorectal Dis. 2007;22:109–14.
• 9. Chacon M, Roca E, Barugel M, et al. Report of solid cancer in patients with gastrointestinal stromal tumors. J Clin Oncol. 2004;22(14S):9065.
• 10. Cohen A, Geller SA, Horowitz I, et al. Experimental models for gastric leiomyosarcoma. The effects of N-methyl- N-nitrosoguanidine in combination with stress, aspirin or sodium taurocholate. Cancer. 1984;53:1088–92.