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Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation

Year 2019, Volume: 3 Issue: 2, 169 - 171, 25.02.2019
https://doi.org/10.28982/josam.523815

Abstract

Aim: Biliary complications were the most common cause of morbidity after living donor liver transplantation. Percutaneous transhepatic biliary drainage (PTBD) is performed in this patients. The purpose of our study was to determine the rate of PTBD related infection (cholangitis and sepsis) after living donor liver transplantation.

Methods: This is a retrospective cohort study. Fifty two patients PTBD procedures were performed after living donor liver transplantation. Two main groups were established; Post PTBD infection group and non-infection group. Demographic characteristics, infectious complications and mortality rates were compared.

Results: PTBD procedure related infection (cholangitis and sepsis) rate was 52% (28 patients) and early (thirty days) mortality rate was 17.9% (5 patients). 

Conclusion: PTBD related infectious complication and mortality rates are high. In these patients we need to be very careful after PTBD.

References

  • 1. Burke DR, Lewis CA, Cardella JF, Citron SJ, Drooz AT, Haskal ZJ, et al. Quality improvement guidelines for percutaneous transhepatic cholangiography and biliary drainage. J Vasc Interv Radiol. 2003;14:243-6.
  • 2. Saad WE, Wallace MJ, Wojak JC, Kundu S, Cardella JF. Quality improvement guidelines for percutaneous transhepatic cholangiography, biliary drainage, and percutaneous cholecystostomy. J Vasc Interv Radiol. 2010;21:789-95.
  • 3. O’Connor O, Buckley J, Maher M. Interventional radiology in oncology. Cancer Treat Res. 2008;143:493-511.
  • 4. Rossi P, Bezzi M, Rossi M, Adam A, Chetty N, Roddie ME, et al. Metallic stents in malignant biliary obstruction: results of a multicenter European study of 240 patients. J Vasc Interv Radiol. 1994;5:279-85.
  • 5. Qian YB, Liu CL, Lo CM, Fan ST. Risk factors for billiary complications after liver transplantation. Arch Surg. 2004 Oct;139(10):1101-5.
  • 6. Spada M, Cescon M, Aluffi A, Zambelli M, Guizzetti M, Lucianetti A, et al. Use of extended right grafts from in situsplit livers in adult liver transplantation: a comparison with whole-liver transplant. Transplant Proc. 2005 Mar;37(2):1164-6.
  • 7. Thethy S, Thomson BNJ, Pleass H, Wigmore SJ, Madhavan K, Akyol M, et al. Management of biliary tract complications after orthotopic liver transplantation. Clin Transplant. 2004 Dec;18(6):647-53.
  • 8. Graziadei IW, Schwaighofer H, Koch R, Nachbaur K, Koenigsrainer A, Margreiter R, et al. Long-term outcome of endoscopic treatment of biliary strictures after liver transplantation. Liver Transpl. 2006 May;12(5):718-25.
  • 9. Zoepf T, Maldonado-Lopez EJ, Hilgard P, Schlaak J, Malago M, Broelsch CE, et al. Endoscopictherapy of posttransplant biliary stenoses after right-sided adult living donor liver transplantation. Clin Gastroenterol Hepatol. 2005 Nov;3(11):1144-9.
  • 10. Starzl TE, Putnam CW, Hansbrough JF, Porter KA, Reid HA. Biliary complications after liver transplantation: with special reference to the biliary cast syndrome and techniques of secondary duct repair. Surgery. 1977 Feb;81(2):212-21.
  • 11. Nomura T, Shirai Y, Hatakeyama K. Bacteribilia and cholangitis after percutaneous transhepatic biliary drainage for malignant biliary obstruction. Dig Dis Sci. 1999 Mar;44(3):542-6.
  • 12. Rösch T, Triptrap A, Born P, Ott R, Weigert N, Frimberger E, et al. Bacteriobilia in percutaneous transhepatic biliary drainage: occurrence over time and clinical sequelae-a prospective observational study. Scand J Gastroenterol. 2003 Nov;38(11):1162-8.
  • 13. Kim JH, Ko GY, Sung KB, Yoon HK, Gwon DI, Kim KR,et al. Bile leak following living donor liver transplantation: clinical efficacy of percutaneous transhepatic treatment. Liver Transpl. 2008 Aug;14(8):1142-9.
  • 14. Cohan RH, Illescas FF, Saeed M, Perlmutt LM, Braun SD, Newman GE, et al. Infectious complications of percutaneous biliary drainage. Invest Radiol. 1986 Sep;21(9):705-9.
  • 15. Audisio RA, Bozzetti F, Severini A, Bellegotti L, Bellomi M, Cozzi G, et al. The occurrence of cholangitis after percutaneous biliary drainage: evaluation of some risk factors. Surgery. 1988 May;103(5):507-12.
  • 16. Joseph PK, Bizer LS, Sprayregen SS, Gliedman ML. Percutaneous transhepatic biliary drainage results and complications in 81 patients. JAMA. 1986 May 23-30;255(20):2763-7.
  • 17. O’Neill SB, O’Connor OJ, Ryan MF, Maher MM. Interventional radiology and the care of the oncology patient. Radiol Res Pract. 2011;2011:160867.
  • 18. Uberoi R, Das N, Moss J, Robertson I. British Society of Interventional Radiology: Biliary Drainage and Stenting Registry (BDSR). Cardiovasc Interv Radiol. 2012;35:127-38.
  • 19. Uberoi R, Ettles DF, Birch PA. A cost saving technique for the introduction of biliary stents. Eur J Radiol. 1995;20:75-6.

Canlı vericili karaciğer nakli sonrası perkütan biliyer drenaja bağlı enfeksiyöz komplikasyonlar

Year 2019, Volume: 3 Issue: 2, 169 - 171, 25.02.2019
https://doi.org/10.28982/josam.523815

Abstract

Amaç: Biliyer komplikasyonlar canlı vericili karaciğer nakli sonrası en sık görülen morbidite nedenidir. Bu hastalarda perkütan transhepatik biliyer drenaj (PTBD) yapılır. Çalışmamızın amacı canlı vericili karaciğer nakli sonrası PTBD’ye bağlı enfeksiyon (kolanjit ve sepsis) oranını belirlemekti.

Yöntemler: Bu retrospektif bir çalışmadır. Elli iki hastaya canlı vericili karaciğer nakli sonrası PTBD işlemi uygulandı. Hastalar iki gruba ayrıldı. PTBD sonrası enfeksiyon gelişen ve gelişmeyen grup. Bu iki grubun demografik özellikleri, enfeksiyöz komplikasyonları ve mortalite oranları karşılaştırıldı.

Bulgular: PTBD prosedürüne bağlı enfeksiyon (kolanjit ve sepsis) oranı % 52 (28 hasta) ve erken (otuz gün) mortalite oranı % 17.9 (5 hasta) idi.

Sonuç: PTBD ile ilişkili infeksiyöz komplikasyon ve mortalite oranları yüksektir. Bu hastalarda PTBD'den sonra çok dikkatli olmak gerekir.

References

  • 1. Burke DR, Lewis CA, Cardella JF, Citron SJ, Drooz AT, Haskal ZJ, et al. Quality improvement guidelines for percutaneous transhepatic cholangiography and biliary drainage. J Vasc Interv Radiol. 2003;14:243-6.
  • 2. Saad WE, Wallace MJ, Wojak JC, Kundu S, Cardella JF. Quality improvement guidelines for percutaneous transhepatic cholangiography, biliary drainage, and percutaneous cholecystostomy. J Vasc Interv Radiol. 2010;21:789-95.
  • 3. O’Connor O, Buckley J, Maher M. Interventional radiology in oncology. Cancer Treat Res. 2008;143:493-511.
  • 4. Rossi P, Bezzi M, Rossi M, Adam A, Chetty N, Roddie ME, et al. Metallic stents in malignant biliary obstruction: results of a multicenter European study of 240 patients. J Vasc Interv Radiol. 1994;5:279-85.
  • 5. Qian YB, Liu CL, Lo CM, Fan ST. Risk factors for billiary complications after liver transplantation. Arch Surg. 2004 Oct;139(10):1101-5.
  • 6. Spada M, Cescon M, Aluffi A, Zambelli M, Guizzetti M, Lucianetti A, et al. Use of extended right grafts from in situsplit livers in adult liver transplantation: a comparison with whole-liver transplant. Transplant Proc. 2005 Mar;37(2):1164-6.
  • 7. Thethy S, Thomson BNJ, Pleass H, Wigmore SJ, Madhavan K, Akyol M, et al. Management of biliary tract complications after orthotopic liver transplantation. Clin Transplant. 2004 Dec;18(6):647-53.
  • 8. Graziadei IW, Schwaighofer H, Koch R, Nachbaur K, Koenigsrainer A, Margreiter R, et al. Long-term outcome of endoscopic treatment of biliary strictures after liver transplantation. Liver Transpl. 2006 May;12(5):718-25.
  • 9. Zoepf T, Maldonado-Lopez EJ, Hilgard P, Schlaak J, Malago M, Broelsch CE, et al. Endoscopictherapy of posttransplant biliary stenoses after right-sided adult living donor liver transplantation. Clin Gastroenterol Hepatol. 2005 Nov;3(11):1144-9.
  • 10. Starzl TE, Putnam CW, Hansbrough JF, Porter KA, Reid HA. Biliary complications after liver transplantation: with special reference to the biliary cast syndrome and techniques of secondary duct repair. Surgery. 1977 Feb;81(2):212-21.
  • 11. Nomura T, Shirai Y, Hatakeyama K. Bacteribilia and cholangitis after percutaneous transhepatic biliary drainage for malignant biliary obstruction. Dig Dis Sci. 1999 Mar;44(3):542-6.
  • 12. Rösch T, Triptrap A, Born P, Ott R, Weigert N, Frimberger E, et al. Bacteriobilia in percutaneous transhepatic biliary drainage: occurrence over time and clinical sequelae-a prospective observational study. Scand J Gastroenterol. 2003 Nov;38(11):1162-8.
  • 13. Kim JH, Ko GY, Sung KB, Yoon HK, Gwon DI, Kim KR,et al. Bile leak following living donor liver transplantation: clinical efficacy of percutaneous transhepatic treatment. Liver Transpl. 2008 Aug;14(8):1142-9.
  • 14. Cohan RH, Illescas FF, Saeed M, Perlmutt LM, Braun SD, Newman GE, et al. Infectious complications of percutaneous biliary drainage. Invest Radiol. 1986 Sep;21(9):705-9.
  • 15. Audisio RA, Bozzetti F, Severini A, Bellegotti L, Bellomi M, Cozzi G, et al. The occurrence of cholangitis after percutaneous biliary drainage: evaluation of some risk factors. Surgery. 1988 May;103(5):507-12.
  • 16. Joseph PK, Bizer LS, Sprayregen SS, Gliedman ML. Percutaneous transhepatic biliary drainage results and complications in 81 patients. JAMA. 1986 May 23-30;255(20):2763-7.
  • 17. O’Neill SB, O’Connor OJ, Ryan MF, Maher MM. Interventional radiology and the care of the oncology patient. Radiol Res Pract. 2011;2011:160867.
  • 18. Uberoi R, Das N, Moss J, Robertson I. British Society of Interventional Radiology: Biliary Drainage and Stenting Registry (BDSR). Cardiovasc Interv Radiol. 2012;35:127-38.
  • 19. Uberoi R, Ettles DF, Birch PA. A cost saving technique for the introduction of biliary stents. Eur J Radiol. 1995;20:75-6.
There are 19 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Research article
Authors

Gökhan Ertuğrul 0000-0002-8351-4220

Selda Aydın This is me

Publication Date February 25, 2019
Published in Issue Year 2019 Volume: 3 Issue: 2

Cite

APA Ertuğrul, G., & Aydın, S. (2019). Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation. Journal of Surgery and Medicine, 3(2), 169-171. https://doi.org/10.28982/josam.523815
AMA Ertuğrul G, Aydın S. Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation. J Surg Med. February 2019;3(2):169-171. doi:10.28982/josam.523815
Chicago Ertuğrul, Gökhan, and Selda Aydın. “Percutaneous Transhepatic Biliary Drainage Related Infectious Complications After Living Donor Liver Transplantation”. Journal of Surgery and Medicine 3, no. 2 (February 2019): 169-71. https://doi.org/10.28982/josam.523815.
EndNote Ertuğrul G, Aydın S (February 1, 2019) Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation. Journal of Surgery and Medicine 3 2 169–171.
IEEE G. Ertuğrul and S. Aydın, “Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation”, J Surg Med, vol. 3, no. 2, pp. 169–171, 2019, doi: 10.28982/josam.523815.
ISNAD Ertuğrul, Gökhan - Aydın, Selda. “Percutaneous Transhepatic Biliary Drainage Related Infectious Complications After Living Donor Liver Transplantation”. Journal of Surgery and Medicine 3/2 (February 2019), 169-171. https://doi.org/10.28982/josam.523815.
JAMA Ertuğrul G, Aydın S. Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation. J Surg Med. 2019;3:169–171.
MLA Ertuğrul, Gökhan and Selda Aydın. “Percutaneous Transhepatic Biliary Drainage Related Infectious Complications After Living Donor Liver Transplantation”. Journal of Surgery and Medicine, vol. 3, no. 2, 2019, pp. 169-71, doi:10.28982/josam.523815.
Vancouver Ertuğrul G, Aydın S. Percutaneous transhepatic biliary drainage related infectious complications after living donor liver transplantation. J Surg Med. 2019;3(2):169-71.