Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals

Hüseyin Kaya; Uğur Yılmaz

doi:10.28982/josam.743354

Research Article

Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals

Year 2020, Volume: 4 Issue: 6, 483 - 485, 01.06.2020

Hüseyin Kaya , Uğur Yılmaz

https://doi.org/10.28982/josam.743354

Abstract

Aim: Many changes occur in the body with aging, from which the eye is also affected. In this study, we aimed to investigate the relationship of corneal densitometry (CD), corneal volume (CV), and central corneal thickness (CCT) with age in healthy individuals.
Methods: This prospective cross-sectional study included 89 healthy individuals aged between 18-79 years. CD, CV, CCT measurements were performed with Pentacam HR (Oculus, Wetzlar, Germany) with a Scheimpﬂug camera. CD measurements were performed manually in the central 6 mm optical zone, 90-270 degrees plane. The data obtained were analyzed with SPSS 21 program.
Results: CD correlated positively, and CV correlated negatively with age (P=0.01, r=0.25 and P=0.04, r=-0.213, respectively). There was no significant correlation between age and CCT (P=0.42, r=-0.08).
Conclusion: Age is a crucial factor affecting overall health. It positively correlated with CD and negatively correlated with CV in healthy individuals. According to these results, these parameters responsible for vision health may be affected by age.

Keywords

Age, Cornea densitometry, Central corneal thickness, Cornea volume, Pentacam

References

1. Meek KM, Knupp C. Corneal structure and transparency. Prog Retin Eye Res. 2015;49:1-16. doi:10.1016/j.preteyeres.2015.07.001
2. Lopes B, Ramos I, Ambrósio R Jr. Corneal densitometry in keratoconus. Cornea. 2014;33:1282–6
3. Otri AM, Fares U, Al-Aqaba MA, Dua HS. Corneal densitometry as an indicator of corneal health. Ophthalmology. 2012;119:501–8.
4. Cennamo G, Forte R, Aufiero B, La Rana A. Computerized Scheimpflug densitometry as a measure of corneal optical density after excimer laser refractive surgery in myopic eyes. J Cataract Refract Surg. 2011:37:1502–6.
5. Pircher N, Pachala M, Prager F, Pieh S, Schmidinger G. Changes in straylight and densitometry values after corneal collagen crosslinking. J Cataract Refract Surg. 2015;41:1038–43.
6. Ares U, Otri AM, Al-Aqaba MA, Faraj L, Dua HS. Wavefront-optimized excimer laser in situ keratomileusis for myopia and myopic astigmatism: refractive outcomes and corneal densitometry. J Cataract Refract Surg. 2012;38:2131–8.
7. Anayol MA, Bostancı B, Şekeroğlu MA, Şimşek M, Günaydın S, Yılmazbaş P. Assessment of Corneal Densitometry in Rheumatoid Arthritis Patients.Turk J Ophthalmol. 2017;47:125-9.
8. Kılınç S, Kasım B, Koçluk Y. Çocukluk çağı keratokonus hastalarında çapraz bağlama tedavisi: Uzun dönem sonuçlarımız. Mersin Univ Saglık Bilim Derg. 2018;11:342-8.
9. Vitályos G, Kolozsvári BL, Németh G, Losonczy G, Hassan Z, Pásztor D. Effects of aging on corneal parameters measured with Pentacam in healthy subjects. Sci Rep. 2019; 9: 3419.
10. Olsen T. Light scattering from the human cornea. Invest Ophthalmol Vis Sci. 1982;23:81–6.
11. Patel S, Winter EJ, McLaren JW, Bourne WM. Objective measurement of backscattered light from the anterior and posterior cornea in vivo. Invest Ophthalmol Vis Sci. 2007;48:166–72.
12. Hillenaar T, Cals RH, Eilers PH, Wubbels RJ, van Cleynenbreugel H, Remeijer L. Normative database for corneal backscatter analysis by in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2011;52:7274–81.
13. Smith G, Brown N, Shun-Shin GA. Light scatter from the central human cornea. Eye. 1990;4:584–8.
14. Ní Dhubhghaill S, Rozema JJ, Jongenelen S, Ruiz Hidalgo I, Zakaria N, Tassignon MJ. Normative values for corneal densitometry analysis by Scheimpflug optical assessment. Invest Ophthalmol Vis Sci. 2014;7:55162-8.
15. Tekin K, Sekeroglu MA, Kiziltoprak H, Yilmazbas P. Corneal Densitometry in Healthy Corneas and Its Correlation With Endothelial Morphometry. Cornea. 2017;36:1336-41.
16. Laule A, Cable MK, Hoffman CE, Hanna C. Endothelial cell population changes of human cornea during life. Arch Ophthalmol. 1978;96:2031–5.
17. Krachmer H, Manis J (Editor), Holland J. Cornea: Fundamentals, Diagnosis and Management 2nd edn.Elsevier Mosby: Beijing, China; 2005.
18. Alzahrani K, Carley F, Brahma A, Morley D, Hillarby MC. Corneal clarity measurements in healthy volunteers across different age groups: Observational study. Medicine (Baltimore). 2017;96(46):e8563. doi:10.1097/MD.0000000000008563.
19. Garzo´n N, Poyales F, Illarramendi I, Mendicute J, Ja´n˜ez O, Caro P, et al. Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction. Int Ophthalmol. 2017;371263-8.
20. Tayyab A, Masrur A, Afzal F, Iqbal F, Naseem K. Central Corneal Thickness and its Relationship to Intra-Ocular and Epidmiological Determinants. JCPSP 2016;26:494-497.
21. Mostafa EM. Central corneal thickness in southern Egypt. Int Ophthalmol. 2014;34:809–15.
22. Çınar Y, Cingü AK, Çınar T, Türkçü FM, Yüksel H, Çaça İ. Comparison of anterior segment parameters with pentacam according to age in emmetropic eyes. Dicle Medical Journal. 2013;40:627-31

Sağlıklı bireylerde korneal dansitometrinin, kornea hacminin ve santral korneal kalınlığın yaş ile ilişkisinin değerlendirilmesi

Year 2020, Volume: 4 Issue: 6, 483 - 485, 01.06.2020

Hüseyin Kaya , Uğur Yılmaz

https://doi.org/10.28982/josam.743354

Abstract

Amaç: Yaş ile beraber vücutta farklı mekanizmalara bağlı birçok değişiklik meydana gelmektedir. Buna bağlı olarak bu değişimlerden göz de etkilenmektedir. Bu sebeple, çalışmamızda sağlıklı bireylerde kornea dansitometrisinin (KD), kornea hacminin (KH) ve santral korneal kalınlığın (SKK) yaş ile olan ilişkisini araştırmayı amaçladık.
Yöntemler: Bu prospektif, kesitsel çalışmaya yaşları 18-79 yaş arasında değişen 89 sağlıklı birey dahil edildi. Bireyler yaşlarına göre 18-40 ve 41-79 yaş olmak üzere iki gruba ayrıldı. KD, KH, SKK ölçümleri Scheimpﬂug kameraya sahip Pentacam HR (Oculus, Wetzlar, Almanya) ile yapıldı. KD ölçümü, santral 6 mm’lik optik zonda, 90-270 derece düzleminde, manuel olarak ölçüldü. Elde edilen veriler Spss 21. programı ile analiz edildi.
Bulgular: KD’nin yaş ile pozitif yönde, KH’nin yaş ile negatif yönde korelasyon gösterdiği bulundu (sırasıyla P=0,018 r=0,25 ve P=0,04 r=-0,213). SKK ile yaş arasında anlamlı bir korelasyon bulunamadı.
Sonuç: Yaş, vücut sağlığını etkileyen önemli bir faktördür. Sağlıklı bireylerde yaşın KD ile pozitif yönde, KH ile negatif yönde korelasyon gösterdiği bulunmuştur. Bu sonuçlara göre görme sağlığından sorumlu bu parametreler yaştan etkileniyor olabilir.

Keywords

Yaş, Kornea dansitometrisi, Santral korneal kalınlık, Kornea hacmi, Pentacam

References

1. Meek KM, Knupp C. Corneal structure and transparency. Prog Retin Eye Res. 2015;49:1-16. doi:10.1016/j.preteyeres.2015.07.001
2. Lopes B, Ramos I, Ambrósio R Jr. Corneal densitometry in keratoconus. Cornea. 2014;33:1282–6
3. Otri AM, Fares U, Al-Aqaba MA, Dua HS. Corneal densitometry as an indicator of corneal health. Ophthalmology. 2012;119:501–8.
4. Cennamo G, Forte R, Aufiero B, La Rana A. Computerized Scheimpflug densitometry as a measure of corneal optical density after excimer laser refractive surgery in myopic eyes. J Cataract Refract Surg. 2011:37:1502–6.
5. Pircher N, Pachala M, Prager F, Pieh S, Schmidinger G. Changes in straylight and densitometry values after corneal collagen crosslinking. J Cataract Refract Surg. 2015;41:1038–43.
6. Ares U, Otri AM, Al-Aqaba MA, Faraj L, Dua HS. Wavefront-optimized excimer laser in situ keratomileusis for myopia and myopic astigmatism: refractive outcomes and corneal densitometry. J Cataract Refract Surg. 2012;38:2131–8.
7. Anayol MA, Bostancı B, Şekeroğlu MA, Şimşek M, Günaydın S, Yılmazbaş P. Assessment of Corneal Densitometry in Rheumatoid Arthritis Patients.Turk J Ophthalmol. 2017;47:125-9.
8. Kılınç S, Kasım B, Koçluk Y. Çocukluk çağı keratokonus hastalarında çapraz bağlama tedavisi: Uzun dönem sonuçlarımız. Mersin Univ Saglık Bilim Derg. 2018;11:342-8.
9. Vitályos G, Kolozsvári BL, Németh G, Losonczy G, Hassan Z, Pásztor D. Effects of aging on corneal parameters measured with Pentacam in healthy subjects. Sci Rep. 2019; 9: 3419.
10. Olsen T. Light scattering from the human cornea. Invest Ophthalmol Vis Sci. 1982;23:81–6.
11. Patel S, Winter EJ, McLaren JW, Bourne WM. Objective measurement of backscattered light from the anterior and posterior cornea in vivo. Invest Ophthalmol Vis Sci. 2007;48:166–72.
12. Hillenaar T, Cals RH, Eilers PH, Wubbels RJ, van Cleynenbreugel H, Remeijer L. Normative database for corneal backscatter analysis by in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2011;52:7274–81.
13. Smith G, Brown N, Shun-Shin GA. Light scatter from the central human cornea. Eye. 1990;4:584–8.
14. Ní Dhubhghaill S, Rozema JJ, Jongenelen S, Ruiz Hidalgo I, Zakaria N, Tassignon MJ. Normative values for corneal densitometry analysis by Scheimpflug optical assessment. Invest Ophthalmol Vis Sci. 2014;7:55162-8.
15. Tekin K, Sekeroglu MA, Kiziltoprak H, Yilmazbas P. Corneal Densitometry in Healthy Corneas and Its Correlation With Endothelial Morphometry. Cornea. 2017;36:1336-41.
16. Laule A, Cable MK, Hoffman CE, Hanna C. Endothelial cell population changes of human cornea during life. Arch Ophthalmol. 1978;96:2031–5.
17. Krachmer H, Manis J (Editor), Holland J. Cornea: Fundamentals, Diagnosis and Management 2nd edn.Elsevier Mosby: Beijing, China; 2005.
18. Alzahrani K, Carley F, Brahma A, Morley D, Hillarby MC. Corneal clarity measurements in healthy volunteers across different age groups: Observational study. Medicine (Baltimore). 2017;96(46):e8563. doi:10.1097/MD.0000000000008563.
19. Garzo´n N, Poyales F, Illarramendi I, Mendicute J, Ja´n˜ez O, Caro P, et al. Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction. Int Ophthalmol. 2017;371263-8.
20. Tayyab A, Masrur A, Afzal F, Iqbal F, Naseem K. Central Corneal Thickness and its Relationship to Intra-Ocular and Epidmiological Determinants. JCPSP 2016;26:494-497.
21. Mostafa EM. Central corneal thickness in southern Egypt. Int Ophthalmol. 2014;34:809–15.
22. Çınar Y, Cingü AK, Çınar T, Türkçü FM, Yüksel H, Çaça İ. Comparison of anterior segment parameters with pentacam according to age in emmetropic eyes. Dicle Medical Journal. 2013;40:627-31

There are 22 citations in total.

Details

Primary Language	English
Subjects	Ophthalmology
Journal Section	Research article
Authors	Hüseyin Kaya 0000-0001-9633-3173 Uğur Yılmaz 0000-0002-0187-5381
Publication Date	June 1, 2020
Published in Issue	Year 2020 Volume: 4 Issue: 6

Cite

APA	Kaya, H., & Yılmaz, U. (2020). Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals. Journal of Surgery and Medicine, 4(6), 483-485. https://doi.org/10.28982/josam.743354
AMA	Kaya H, Yılmaz U. Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals. J Surg Med. June 2020;4(6):483-485. doi:10.28982/josam.743354
Chicago	Kaya, Hüseyin, and Uğur Yılmaz. “Investigation of the Relationship of Corneal Densitometry, Corneal Volume and Central Corneal Thickness With Age in Healthy Individuals”. Journal of Surgery and Medicine 4, no. 6 (June 2020): 483-85. https://doi.org/10.28982/josam.743354.
EndNote	Kaya H, Yılmaz U (June 1, 2020) Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals. Journal of Surgery and Medicine 4 6 483–485.
IEEE	H. Kaya and U. Yılmaz, “Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals”, J Surg Med, vol. 4, no. 6, pp. 483–485, 2020, doi: 10.28982/josam.743354.
ISNAD	Kaya, Hüseyin - Yılmaz, Uğur. “Investigation of the Relationship of Corneal Densitometry, Corneal Volume and Central Corneal Thickness With Age in Healthy Individuals”. Journal of Surgery and Medicine 4/6 (June 2020), 483-485. https://doi.org/10.28982/josam.743354.
JAMA	Kaya H, Yılmaz U. Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals. J Surg Med. 2020;4:483–485.
MLA	Kaya, Hüseyin and Uğur Yılmaz. “Investigation of the Relationship of Corneal Densitometry, Corneal Volume and Central Corneal Thickness With Age in Healthy Individuals”. Journal of Surgery and Medicine, vol. 4, no. 6, 2020, pp. 483-5, doi:10.28982/josam.743354.
Vancouver	Kaya H, Yılmaz U. Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals. J Surg Med. 2020;4(6):483-5.

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