Review

Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021

Volume: 9 Number: 4 November 30, 2022
EN

Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021

Abstract

This work covers the selected synthetic papers of imidazo[1,2-a]pyrimidine and its derivatives between the years 2000 and 2021. Synthesis of the heterocyclic moiety, application of this scaffold to biological activities, and secondary applications like corrosion inhibition are provided. The authors hope that readers will find the treatise useful.

Keywords

References

  1. 1. Kochergin PM, Mazur IA, Rogul’chenko GK, Aleksandrova EV, Mandrichenko BE. Studies in the imidazole series. 100. Synthesis of derivatives of imidazo[1,2-a]pyrimidine from 2-aminopyrimidines, methyl aryl ketones, and halogens. Chem Heterocycl Compd. 2000;36(12):1437–40.
  2. 2. Saldabol N, Popelis J, Lando O, Slavinska V. 2-(2-furyl) imidazo [1, 2-a] pyrimidine synthesis and electrophilic substitution reactions. Chem Heterocycl Compd. 2006;42(4):495–9.
  3. 3. Laquintana V, Denora N, Lopedota A, Suzuki H, Sawada M, Serra M, et al. N -Benzyl-2-(6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2- a ]pyridin-3-yl)- N -(6- (7-nitrobenzo[ c ][1,2,5]oxadiazol-4-ylamino)hexyl)acetamide as a New Fluorescent Probe for Peripheral Benzodiazepine Receptor and Microglial Cell Visualization. Bioconjug Chem. 2007 Sep 1;18(5):1397–407.
  4. 4. Jensen MS, Hoerrner RS, Li W, Nelson DP, Javadi GJ, Dormer PG, et al. Efficient Synthesis of a GABA A α 2,3 -Selective Allosteric Modulator via a Sequential Pd-Catalyzed Cross-Coupling Approach. J Org Chem. 2005 Jul 1;70(15):6034–9.
  5. 5. Blackaby WP, Atack JR, Bromidge F, Castro JL, Goodacre SC, Hallett DJ, et al. Imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. Bioorg Med Chem Lett. 2006 Mar;16(5):1175–9.
  6. 6. Oganisyan AS, Noravyan A, Dzhagatspanyan I, Nazaryan I, Akopyan A. Derivatives of condensed thienopyrimidines: Synthesis and anticonvulsant and tranquilizer activity of hydrochlorides of pyrano [4′, 3′: 4, 5] thieno [3, 2-e] imidazo [1, 2-a] pyrimidines. Pharm Chem J. 2007;41(11):588–90.
  7. 7. Kiselyov AS, Smith L. Novel one pot synthesis of polysubstituted pyrazolo[1,5-a]- and imidazo[1,2-a]pyrimidines. Tetrahedron Lett. 2006 Apr;47(15):2611–4.
  8. 8. Parchinsky VZ, Shuvalova O, Ushakova O, Kravchenko DV, Krasavin M. Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products. Tetrahedron Lett. 2006 Feb;47(6):947–51.

Details

Primary Language

English

Subjects

Inorganic Chemistry

Journal Section

Review

Publication Date

November 30, 2022

Submission Date

April 29, 2022

Acceptance Date

October 10, 2022

Published in Issue

Year 2022 Volume: 9 Number: 4

APA
Kobak, R. Z., & Akkurt, B. (2022). Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021. Journal of the Turkish Chemical Society Section A: Chemistry, 9(4), 1335-1386. https://doi.org/10.18596/jotcsa.1110922
AMA
1.Kobak RZ, Akkurt B. Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021. JOTCSA. 2022;9(4):1335-1386. doi:10.18596/jotcsa.1110922
Chicago
Kobak, Rabia Zeynep, and Barbaros Akkurt. 2022. “Formation and Uses of Imidazo[1,2-A]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021”. Journal of the Turkish Chemical Society Section A: Chemistry 9 (4): 1335-86. https://doi.org/10.18596/jotcsa.1110922.
EndNote
Kobak RZ, Akkurt B (November 1, 2022) Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021. Journal of the Turkish Chemical Society Section A: Chemistry 9 4 1335–1386.
IEEE
[1]R. Z. Kobak and B. Akkurt, “Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021”, JOTCSA, vol. 9, no. 4, pp. 1335–1386, Nov. 2022, doi: 10.18596/jotcsa.1110922.
ISNAD
Kobak, Rabia Zeynep - Akkurt, Barbaros. “Formation and Uses of Imidazo[1,2-A]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021”. Journal of the Turkish Chemical Society Section A: Chemistry 9/4 (November 1, 2022): 1335-1386. https://doi.org/10.18596/jotcsa.1110922.
JAMA
1.Kobak RZ, Akkurt B. Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021. JOTCSA. 2022;9:1335–1386.
MLA
Kobak, Rabia Zeynep, and Barbaros Akkurt. “Formation and Uses of Imidazo[1,2-A]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 9, no. 4, Nov. 2022, pp. 1335-86, doi:10.18596/jotcsa.1110922.
Vancouver
1.Rabia Zeynep Kobak, Barbaros Akkurt. Formation and Uses of Imidazo[1,2-a]pyrimidines and Related Compounds: A Review Comprising Years 2000-2021. JOTCSA. 2022 Nov. 1;9(4):1335-86. doi:10.18596/jotcsa.1110922

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