Indirect Determination of Diclofenac Sodium Through its Interaction with the Aniline Oxidation Peak

Abstract

The voltammetric measurement of diclofenac sodium was investigated using an electrochemical sensor consisting of a glassy carbon electrode (GCE) modified with aniline conducting polymer and a differential pulse voltammetric (DPV) method. Diclofenac sodium behavior was investigated through its interaction with poly aniline oxidation peak; due to diclofenac sodium adsorption on the surface of the bare glassy carbon electrode, it gives an unstable oxidation peak at 0.4V versus Ag/AgCl.saturated.KCl. We attempted to solve this issue by plating the electrode with aniline and monitoring the interaction peak between diclofenac sodium and aniline oxidation peak. The impact of pH was investigated, optimum conditions were tested, and calibration curves were constructed. Glassy carbon/poly aniline electrode (GC/PAn) results in two straight lines with R2 values of 0.9812 and 0.9772 when current is plotted against concentrations at low concentration and high concentration, respectively. The limit of detection (LOD) and limit of quantification (LOQ) were 0.1282 × 10-7 M and 0.4275 × 10-7 M, respectively. Compared with other sensors, it was observed that the proposed electrochemical sensor has a wider linear range and lower detection limit. The suggested method was applied successfully for quantitating diclofenac sodium in tablet formulation supplied by Samaraa Drugs Industry (SDI)with accepted results of recovery of diclofenac sodium.

Keywords

• Diclofenac sodium
• polyaniline
• differential pulse voltammetry
• modified glassy carbon electrode.

References

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