Fluorescent Polymeric Sensor for Selective and Sensitive Detection of Cu(II) ions in Aqueous Medium

Abstract

In our study, a selective and sensitive determination method was developed for Cu(II) ions by spectrofluorimetry. For this purpose, a polymeric membrane was prepared to determine Cu(II) ions by curing crosslinkers, functional monomers, and photoinitiators under UV light. The membrane was characterized, and the optimum conditions for determining Cu(II) ions were systematically investigated. The detection was performed at pH 5.0 in as little as 20 seconds at excitation and emission wavelengths of 376 nm and 455 nm, respectively. The linear range was 7.86.10-9-1.57.10-7 mol/L, and the method's detection limit was 2.24.10-9 mol/L. In addition, the sensor's repeatability, stability, and life were examined, and recovery studies were conducted. As a result, the developed method has been successfully applied to wastewater samples as a real sample. In addition, determining Cu(II) ions at low concentrations can be done quickly, reliably, and with high selectivity and sensitivity.

Keywords

• Cu(II) determination
• fluorimetric sensor
• photocuring
• polymeric membrane

References

1. 1. Kiran RB, Renu S. Effect of heavy metals: An overview, Materials Today: Proceedings. 2022; 51(1): 880-5. Available from: ..
2. 2. Marchetti C. Role of calcium channels in heavy metal toxicity.International Scholarly Research Notices. 2013; 2013:184360. Available from: .
3. 3. Potocki S, Rowinska-Zyrek M, Witkowska D, Pyrkosz M, Szebesczyk A, Krzywoszynska K, Kozlowski H. Metal transport and homeostasis within the human body: Toxicity associated with transport abnormalities. Curr. Med. Chem.  2012; 19:2738–59. Available from: .
4. 4. Cannas D, Loi E, Serra M, Firinu D, Valera P, Zavattari P. Relevance of Essential Trace Elements in Nutrition and Drinking Water for Human Health and Autoimmune Disease Risk. Nutrients. 2020; 12(7):2074. Available from: .
5. 5. Brindha K, Paul R, Walter J, Tan ML, Singh MK. Trace metals contamination in groundwater and implications on human health: comprehensive assessment using hydrogeochemical and geostatistical methods. Environmental Geochemistry and Health. 2020; 42, 3819–39. Available from: .
6. 6. Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary Toxicology. 2014; 7(2):60-72. Available from: .
7. 7. Briffa J, Sinagra E, Blundell R. Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon 2020; 6(9): e0469. Available from: .
8. 8. He ZL, Yang XE, Stoffella PJ. Trace elements in agroecosystems and impacts on the environment. Journal of Trace Elements in Medicine and Biology. 2005; 19(2–3):125–40. Available from: .

9. 9. Gautam PK, Gautam RK, Banerjee S et al. Heavy metals in the environment: fate, transport, toxicity and remediation technologies. Editor(s): Pathania D, Heavy Metals: Sources, Toxicity and Remediation Techniques, Nova Sci Publishers. 2016; 60, 101-30.
10. 10. Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary Toxicology. 2014; 7(2):60-72. Available from: .
11. 11. Tchounwou PB, Yedjou CG, Patlola AK, Sutton DJ. Heavy metal toxicity and the environment. Molecular, Clinical and Environmental Toxicology. 2012; 101:133-64. Available from: .
12. 12. Bost M, Houdart S, Oberli M, Kalonji E, Huneau JH, Margaritis I. Dietary copper and human health: Current evidence and unresolved issues. Journal of Trace Elements in Medicine and Biology. 2016; 35:107- 15. Available from: .
13. 13. Feng S, Gao Q, Gao X, Jiao Y. Fluorescent sensor for copper(II) ion based on coumarin derivative and its application in cell imaging. Elsevier Inorganic Chemistry Communications. 2019; 102:51–6. Available from: .
14. 14. Schultze MO, Elvehjem CA, Hart EB. Studies on the copper content of the blood in nutritional anemia. Journal of Biological Chemistry. 1936; 116, 107- 18. Available from: .
15. 15. Ramdass A, Sathish V, Babu E, Velayudham M, Thanasekaran P, Rajagopal S. Recent developments on optical and electrochemical sensing of copper (II) ion based on transition metal complexes. Coordination Chemistry Reviews. 2017; 343:278–307. Available from: .
16. 16. Gholivand MB; Nasrabadi MR, Ganjali MR, Salavati­Niasari M. Highly selective and sensitive copper membrane electrode based on a new synthesized Schiff base. Talanta. 2007; 73(3):553–60. Available from: .
17. 17. Zhu Z, McKendry R, Chavez CL Signaling in Copper Ion Homeostasis. Editor(s): Storey KB, Storey JM. Volume 1, 2000, Pages 293-300. Available from: :
18. 18. Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology. Copper. Biomedicine & Pharmacotherapy. 2003; 57(9):386-98. Available from: .
19. 19. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press. 2001. Available from: .
20. 20. Gray JP, Suhali-Amacher N, Ray SD. Metals and Metal Antagonists. Editor(s): Sidhartha D. Ray, Side Effects of Drugs Annual. 2017; 39:197-208. Available from: .
21. 21. Pizarro F, Olivares M, Uauy R, Contreras P, Rebelo A, Gidi V. Acute gastrointestinal effects of graded levels of copper in drinking water. Environmental Health Perspectives. 1999; 107(2):117–21. Available from: .
22. 22. Taylor AA, Tsuji JS, Garry MR, McArdle ME, Goodfellow Jr WL, Adams WJ, Menzie CA. Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper. Environmental Management. 2020; 65(1):131-59. Available from: .
23. 23. Shi F, Cui S, Liu H, Pu S. A high selective fluorescent sensor for Cu2+ in solution and test paper strips. Dyes and Pigments. 2020; 173:107914. Available from: .
24. 24. Zhang X, Guo X, Yuan H, Jia X, Dai B. One-pot synthesis of a natural phenol derived fluorescence sensor for Cu(II) and Hg(II) detection. Dyes and Pigments. 2018; 155:100-6. Available from: .
25. 25. WHO (World Health Organization). Guidelines for drinking-water quality: fourth edition incorporating the first and second addenda. Geneva: World Health Organization; 2022. Licence: CC BY-NC-SA 3.0 IGO.
26. 26. Ali A, Shen H, Yin X. Simultaneous determination of trace amounts of nickel, copper and mercury by liquid chromatography coupled with flow-injection on-line derivatization and preconcentration. Anal Chim Acta. 1998; 369(3):215–23. Available from: .
27. 27. Chen H, Jia S, Zhang J, Jang M, Chen X, Koh H, Wang Z. Sensitive detection of copper (II) ion based on conformational change of peptide by surface plasmon resonance spectroscopy. Analytical Methods. 2015; 20(7): 8942-6. Available from: .
28. 28. Mefteh W, Chevalier Y, Bala C, Jaffrezic-Renault N. Voltammetric Detection of Copper Ions on a Gold Electrode Modified with a N-methyl-2-naphthyl-cyclam film. Analytical Letters. 2018; 51(7): 971-82. Available from: .
29. 29. Şahan S, Şahin U. Determination of Copper(II) Using Atomic Absorption Spectrometry and Eriochrome Blue Black R Loaded Amberlite XAD‐1180 Resin. Clean- Soil Air Water. 2010; 38:485-91. Available from: .
30. 30. Cao Y, Feng J, Tang L, Yu C, Mo G, Deng B. A highly efficient introduction system for single cell- ICP-MS and its application to detection of copper in single human red blood cells. Talanta. 2020; 206:120174. Available from: .
31. 31. Zhou F, Li C, Zhu H, Li Y. A novel method for simultaneous determination of zinc, nickel, cobalt and copper based on UV–vis spectrometry. Optik. 2019; 182:58-64. Available from: .
32. 32. Cao F, Jiao F, Ma S, Dong D. Laser-induced breakdown spectroscopy mediated amplification sensor for copper (II) ions detection using click chemistry. Sensors and Actuators B: Chemical. 2020; 371:132594. Available from: .
33. 33. Karadjov M, Velitchkova N, Veleva O, Vekichkov S, Markov P, Daskalova N. Spectral interferences in the determination of rhenium in molybdenum and copper concentrates by inductively coupled plasma optical emission spectrometry (ICP-OES). Spectrochimica Acta Part B: Atomic Spectroscopy. 2016; 119:76-82. Available from: .
34. 34. Feng S, Gao Q, Gao X, Yin J, Jiao Y. Fluorescent sensor for copper(II) ions based on coumarin derivative and its application in cell imaging. Inorganic Chemistry Communications. 2019; 102:51-6. Available from: .
35. 35. Fan J, Zhan P, Hu M, Sun W, Tang J, Wang J, Sun S, Song F, Peng X. A fluorescent ratiometric chemodosimeter for Cu2+ based on TBET and its application in living cells. Organic Letters. 2013; 15(3):492-5. Available from: .
36. 36. Jiang Y, Huang Z, Dai H, Wang L, Ying L, Kou X. A highly selective and sensitive fluorescent sensor for copper(II) ion characterized by one dichlorofluorescein moiety and two azathia-crown ether. Asian Journal of Chemistry. 2013; 25:8292- 6. Available from: .
37. 37. Sam-ang P, Silpcharu K, Sukwattanasinitt M, Rashatasakhon P. Hydrophilic Truxene Derivative as a Fluorescent off-on Sensor for Copper (II) Ion and Phosphate Species. Journal of Fluorescence. 2019; 29:417-24. Available from: .
38. 38. Farhi A, Firdaus F, Saeed H, Mujeeb A, Shakir M, Owais M. A quinoline-based fluorescent probe for selective detection and real-time monitoring of copper ions- A differential colorimetric approach. Photochemical and Photobiological Sciences. 2019; 18:3008-15. Available from: .
39. 39. Birtane H, Şen F, Bozdağ B, Kahraman MV. Antibacterial UV-photocured acrylic coatings containing quaternary ammonium salt. Polymer Bulletin. 2021; 78, 3577–88. Available from: .
40. 40. Cubuk S, Taşci N, Kahraman MV, Bayramoğlu G, Kök Yetimoglu E. Reusable fluorescent photocrosslinked polymeric sensor for determining lead ions in aqueous media. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2016; 159:106-12. Available from: .
41. 41. Liu SR, Wu SP. An NBD-based Sensitive and Selective Fluorescent Sensor for Copper (II) Ion. Journal of Fluorescence. 2010; 21:1599–1605. Available from: .
42. 42. MacDougall D, Crummett WB et al. Guidelines for data acquisition and data quality evaluation in environmental chemistry. Analytical Chemistry. 1980; 52(14):2242-9. Available from: .
43. 43. Mohadesi A, Taher MA. Voltammetric determination of Cu (II) in natural waters and human hair at a meso-2, 3-dimercaptosuccinic acid self-assembled gold electrode. Talanta. 2007; 72(1):95-100. Available from: .
44. 44. Poosinuntakul N, Parnklang T, Sitiwed T, Chaiyo S, Kladsomboon S, Chailapakul O, Apilux A. Colorimetric assay for determination of Cu (II) ions using L-cysteine functionalized silver nanoplates. Microchemical Journal. 2020; 158:105101. Available from: .
45. 45. Pourbasheer E, Morsali, S, Banaei A, Aghabakazadeh S, Ganjali MR, Norouzi P. Design of a novel optical sensor for determination of trace amounts of copper by UV–visible spectrophotometry in real samples. Journal of Industrial and Engineering Chemistry. 2018; 32(3):e4110. Available from: .
46. 46. Mei L, Xiang, Y, Li N, Tong A. A new fluorescent probe of rhodamine B derivative for the detection of copper ion. Talanta. 2007; 72(5):1717-22. Available from: .
47. 47. Peronico VCD, Raposo JL Jr. Ultrasound-assisted extraction for the determination of Cu, Mn, Ca, and Mg in alternative oilseed crops using flame atomic absorption spectrometry. Food Chemistry. 2016; 196:1287-92. Available from: .
48. 48. Ali TA, Abd-Elaal AA, Mohamed GG. Screen printed ion selective electrodes based on self-assembled thiol surfactant-gold-nanoparticles for determination of Cu (II) in different water samples. Microchemical Journal. 2021; 160:105693. Available from: .
49. 49. Bilal M, Kazi TG, Afridi HI, Arain MB, Baig JA, Khan M, Khan N. Application of conventional and modified cloud point extraction for simultaneous enrichment of cadmium, lead and copper in lake water and fish muscles. Journal of Industrial and Engineering Chemistry. 2016; 40:137-44. Available from: .
50. 50. Durukan İ, Arpa Şahin A, Şatıroğlu N, Bektaş S. Determination of iron and copper in food samples by flow injection cloud point extraction flame atomic absorption spectrometry. Microchemical Journal. 2011; 99(1):159-63. Available from: .
51. 51. Atanassova D, Stefanova V, Russeva E. Co-precipitative pre-concentration with sodium diethyldithiocarbamate and ICP-AES determination of Se, Cu, Pb, Zn, Fe, Co, Ni, Mn, Cr and Cd in water. Talanta. 1998; 47(5):1237-43. Available from: .
52. 52. Almeida JS, Souza OCCO, Teixeira LSG. Determination of Pb, Cu and Fe in ethanol fuel samples by high-resolution continuum source electrothermal atomic absorption spectrometry by exploring a combination of sequential and simultaneous strategies. Microchemical Journal. 2017; 137:22–6. Available from: .
53. 53. Hachmöller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M,  Walch A, Karst U. Investigating the influence of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry. Journal of Trace Elements in Medicine and Biology. 2017; 44:71-5. Available from: .
54. 54. Yu J, Yang S, Lu Q, Sun D, Zheng J, Zhang X, Wang X, Yang W. Evaluation of liquid cathode glow discharge-atomic emission spectrometry for determination of copper and lead in ores samples. Talanta. 2017; 164(1):216-21. Available from: .