A Method Optimization Study for Atomic Absorption Spectrometric Determination of Nickel Content in Meclizine Hydrochloride

Abstract

Heavy metals are naturally occurring elements. Their widespread distribution in the environment has raised questions about their possible consequences on both human health and the environment. So, the toxicological and safety assessment of these heavy metals is one of the major issues in recent days. An accurate method for the determination of nickel in bulk drugs was required due to its high toxicity risk. The aim of the current study was to develop a validated analytical technique for the determination of nickel content in bulk drugs using an atomic absorption spectrometer. The wavelength was 232 nm, and the integration duration was 5.0 seconds. It was determined that the detection and quantification limits were 0.051 mg/L and 0.15 mg/L, respectively. The recovery rates for nickel concentrations spiked by 50%, 100%, and 150% in meclizine hydrochloride were determined to be 109.33%, 96.5%, and 97.55%, respectively. The status of heavy metals and trace elements in bulk drugs were discussed in this article, along with an easy-to-use AAS approach that can be applied at the industrial level to ensure the quality and uniformity of bulk medications and other related products.

Keywords

• Atomic absorption
• Catalyst
• Flame atomization
• Heavy metal toxicity
• Nickel

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