Characterization and Lidocaine Release Behavior of Chitosan/ Sodium Alginate/ Clinoptiolite Nanocomposite Hydrogel

Abstract

In this study, the novel nanocomposites were prepared from the natural biopolymers, chitosan (CS), sodium alginate (SA) and clinoptiolite (CL) particles, and also having glutaraldehyde as a crosslinker by cryogelation technique. CS biopolymer was produced from crayfish Astacus leptodactylus. Characterization of the prepared CS, CS-co-SA (CS/SA) and drug loaded CS/SA/ CL nanocomposite were performed by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) analyses. The anesthetic drug release behavior of the prepared nanocomposite was investigated for the model drug lidocaine (LD) using UV-Vis spectrophotometry and High Performance Liquid Chromatography (HPLC) techniques. The effect of different LD and CL content on the drug release behavior of the prepared nanocomposite were studied. LD release data was fitted to various kinetic models to study the drug release behavior. The LD release from all the prepared nanocomposite hydrogels fitted the Korsmeyer-Peppas model. The swelling and drug release properties of the new CS-based nanocomposite hydrogels were improved with the inclusion of SA and CL in the gel structure.

Keywords

• Chitosan
• Clinoptiolite
• Drug Realese
• Lidocaine
• Sodium alginate

References

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