INTERRELATION AMONG SERUM LITHIUM LEVELS AND BONE METABOLISM AND SOME BIOCHEMICAL PARAMETERS IN PRE AND POST-MENAUPOSAL WOMEN

Abstract

The target of this study is to determine the interrelation among serum Li level on bone metabolism (Ca, P, Parathormon, and Vitamin-D), sex and metabolic hormones (estrogen, FSH, LH and TSH), and some biochemical parameters in premenopausal and postmenopausal women. The study is carried out with 10 women: 5 premenopausal and 5 postmenopausal women. The serum Li levels, bone metabolism indicators (i.e., ALP, Ca, P, Mg, Cu, Zn) and some biochemical parameters such as serum tryglyceride, alkalene phosphatase, total cholesterol, HDL, LDL and cholesterol levels were determined. The estrogen blood level of women in menopause period was found to be lower than that of women in pre-menopause period (p<0.01) and the FSH level was found to be higher (p<0.01). In the lipid profile the triglyceride level in the post-menopause period was found to be low (p<0.05) and HDL (p<0.001), LDL (p<0.001) and the cholesterol levels were found to be high (p<0.001). The alkalene phosphatase (p<0.001) and Vitamin-D levels (p<0.001) were found to decrease. When the mineral levels were investigated no meaningful difference was observed in the serum magnesium and copper levels while zinc (p<0.01) and phosphorus (p<0.005) levels were observed to increase, the calcium levels (p<0.05) decreased and Li levels considerably decreased (p<0.0001). According to the results obtained it was determined for the first time that Li defficiency can be related with menopause and the related diseases and thus Li therapy can be used in developing new treatment protocols of menopause as an alternative method.

References

1. Marslı M S. Whitehead MI. Management of the Menapause, Bulletin, 1992, 487.426. http://bmb.oxfordjournals.org/content/48/2/426.short
2. Black DM, Rosen CF. Postmenopausal Osteoporosis. N Engl J Med 2016 Jan;374:254-262. DOI: 10.1056/NEJMcp1513724
3. Civitelli R, Agnusdei D, Nardi P, Zacchei F, Avioli LV, Gennari C. Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption, and 25-hydroxyvitamin D-1 alpha-hydroxylase reserve in postmenopausal osteoporosis. Calcif Tissue Int. 1988 Feb;42(2):77-86. http://www.ncbi.nlm.nih.gov/pubmed/3127028
4. Valquiria A. Coronado Dorce, Joao Palermo-Neto, Lithium Effects on Estrogen-Induced Supersensitivity in Rats, Brain Research Bulletin, 1992 Aug;29(2):239-241. http://www.ncbi.nlm.nih.gov/pubmed/1525677.
5. Wagner E R, Zhu G, Zhang B-Q, Luo Q, Shi Q, Huang E, Gao Y, Gao J L, Kim S H, Rastegar F, Yang K, He B C, Chen L, Zuo G W, Bi Y, Su Y, Luo J, Luo X, Huang J, Deng Z L, Reid R R, Luu H H, Haydon R C, He T C. The Therapeutic Potential of the wnt Signaling Pathway in Bone Disorders, Current Mol. Pharm. 2011 Ju;4(1):14-25. http://www.ncbi.nlm.nih.gov/pubmed/20825362
6. Swiecicka A, Malige M. Lithium-Induced Hypercalcemia and Parathyroid Dysfunction, Endocrine Abstracts. 2010;21:P90. http://www.endocrine-abstracts.org/ea/0021/ea0021p90.htm
7. Thase M E, Sachs G S. Bipolar depression: pharmacotherapy and related therapeutic strategies, Biol. Psychiatry. 2000 Sep:48(6):558-572. http://www.ncbi.nlm.nih.gov/pubmed/11018227.
8. Da Silva C.M. L., V.G.K. Almeida, R.J. Casella, Determination of lithium in pharmaceutical formulations used in the treatment of bipolar disorder by flow injection analysis with spectrophotometric detection. Talanta. 2007 Nov;73(4): 613-620. DOI: 10.1016/j.talanta.2007.04.019.

9. Begic Z, Balic D, Rizvanovic M. The Association Between Lipid Profile and Bone Density in Postmenopausal Women. Med Arh. 2012;66(6):378-381. http://www.ncbi.nlm.nih.gov/pubmed/23409515.
10. Santoro N, Epperson CN, Mathews SB. Menopausal Symptoms and Their Management. Endocrinol Metab Clin North Am. 2015 Sep;44(3):497–515. doi: 10.1016/j.ecl.2015.05.001
11. Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2346-8. http://www.ncbi.nlm.nih.gov/pubmed/11073836.
12. Saha KR, Rahman MM, Paul AR, Das S, Haque S, Jafrin W, Mia AR. Changes in lipid profile of postmenopausal women. Mymensingh Med J. 2013 Oct;22(4):706-11. http://www.ncbi.nlm.nih.gov/pubmed/24292300.
13. Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo MC, Demer LL. Atherogenic diet and minimally oxidized low-density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J. Bone Miner Res. 1999;14:2067-2078. DOI. 10.1359/jbmr.1999.14.12.2067.
14. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL. Atherogenic high fat diet reduces bone mineralization in mice. J Bone Miner Res. 2001;16:182-188. DOI. 10.1359/jbmr.2001.16.1.182.
15. Crilly RG, Jones MM, Horsman A, Nordin BE, Rise in plasma alkaline phosphatase at the menopause. Clin Sci (Lond). 1980 Apr;58(4):341-2. http://www.ncbi.nlm.nih.gov/pubmed/7379460.
16. Sunyecz JA, The use of calcium and vitamin D in the management of osteoporosis. Ther Clin Risk Manag. 2008 Aug;4(4):827–836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621390/
17. McLaren-Howard J, Grant ECG, Davies S. Hormone Replacement Therapy and Osteoporosis: Bone Enzymes and Nutrient Imbalances. J Nutr Environ Med. 1998 Jul;8:129-138. 10.1080/13590849862168.
18. Heaney RP. Phosphorus Nutrition and the Treatment of Osteoporosis. 2004 Jan;79(1):91–97. DOI: http://dx.doi.org/10.4065/79.1.91
19. McLaren-Howard J, Grant ECG, Davies S. Hormone Replacement Therapy and Osteoporosis: Bone Enzymes and Nutrient Imbalances. J Nutr Environ Med, 1998 Jul;8:129-138. DOI. 10.1080/13590849862168.
20. Takeda E, Yamamoto H, Yamanaka-Okumura H, Taketani Y. Dietary phosphorus in bone health and quality of life. Nutr Rev. 2012 Jun;70(6):311-21. doi: 10.1111/j.1753-4887.2012.00473.x.
21. Osredkar J, Sustar N. Copper and Zinc, Biological Role and Significance of Copper/Zinc Imbalance. Journal of Clinical Toxicology. 201 Dec;S3:001. doi:10.4172/2161- 0495.S3-001. http://www.omicsonline.org/copper-and-zinc-biological-role-and-significance-of-copper-zincimbalance-2161-0495.S3-001.php?aid=3055
22. Mutlu M, Argun M, Kilic E, Saraymen R, Yazar S. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal post-menopausal women. J Int Med Res 2007;35:692-5. DOI: 10.11138/ccmbm/2015.12.1.018
23. Valquiria A. Coronado Dorce, Joao Palermo-Neto, Lithium Effects on Estrogen-Induced Supersensitivity in Rats, Brain Research Bulletin, 1992, 29 (2): 239-241. DOI:10.1016/0361-9230(92)90032-S.