A Novel ZnO Nanoparticle as Drug Nanocarrier in Therapeutic applications: Kinetic Models and Error Analysis

Year 2019, , 119 - 132, 15.06.2019

Selcan Karakuş

https://doi.org/10.18596/jotcsa.405505

Cited By: 3

Abstract

Nanotechnology
provides promising possibilities for several biomedical and pharmaceutical  applications in
the medicine industry. Nanostructures play a major role in the recent
strategies of  technology suitable for novel
drug applications. In this work, clindamycin phosphate (CliP) (topical
anti-inflammatory drug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle)
nanostructures were synthesised using the sonochemical technique at room
temperature. The characterization of the clindamycin phosphate- xanthan gum/ZnO
(CliP-XaG/ZnO) nanostructure has been carried out by Fourier transform infrared
(FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated in
vitro the mechanism of drug delivery system at different pH media (1.2 and 7.4).
In this study, the concentration of drug in the solution was analyzed by UV–vis
spectroscopy method and several kinetic models and error analysis were
calculated to prove a connection with results. The Higuchi model had the best
correlation parameters. The percentage of swelling
ratio (%) reached up 105% in XaG (pH 1.2) and 190% in XaG/ZnO (pH 1.2) And the
swelling ratio (%) reached up 530% within in XaG (pH 7.4) and 655% within in
XaG/ZnO (pH 7.4). The results show that the capacity of XaG / ZnO can be
preferred as a novel topical anti-inflammatory drug carrier. 

Keywords

Xanthan gum, controlled drug delivery, sonochemistry, ZnO

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