Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Abstract

The aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651),  1 Hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959)  were used as photo-initiators in the synthesis of hydrogels and  hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristics properties of hydrogels. Photopolymerization technique was selected to synthesize for hydrogels.  Swelling and drug release studies have been performed under different pH conditions.

Keywords

• Hydrogels,Photopolymerization,Donepezil HCl,Polyethylene diacyrlate,Alzheimer's Disease

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